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  4. MRM2 Antibody, Biotin conjugated

MRM2 Antibody, Biotin conjugated

  • 中文名稱：
    MRM2兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA883420LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MRM2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MRM2
  • 別名：
    FJH1 antibody; FTSJ2 antibody; MRM2 antibody; Protein ftsJ homolog 2 antibody; Putative ribosomal RNA methyltransferase 2 antibody; Ribosomal RNA methyltransferase 2 antibody; RRMJ2_HUMAN antibody; rRNA (uridine-2''-O-)-methyltransferase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human rRNA methyltransferase 2, mitochondrial protein (19-246AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
  • 基因功能參考文獻：
    1. Targeted exome sequencing of genes encoding the mitochondrial proteome identified a damaging mutation, c.567 G > A, affecting a highly conserved amino acid residue (p.Gly189Arg) of the MRM2 protein. Our findings establish that defective MRM2 causes a MELAS-like phenotype, and suggests the genetic screening of the MRM2 gene in patients with a m.3243 A > G negative MELAS-like presentation. PMID: 28973171
    2. miR-542-3p functions as a suppressor gene by targeting and upregulating FTSJ2, thus inhibiting the malignancy of non-small cell lung cancer cells PMID: 28866101
    3. MRM2 and MRM3 are human mitochondrial methyltransferases involved in the modification of 16S rRNA and are important factors for the biogenesis and function of the large subunit of the mitochondrial ribosome. PMID: 25009282
    4. Data show that 2'-O-methyltransferases MRM1, MRM2, and RNMTL1 are responsible for modification of large subunit rRNA at residues G1145, U1369, and G1370, respectively. PMID: 25074936
    5. FTSJ2 possesses suppressive effects on the invasion and migration of cancer cells. PMID: 24595062
    6. FTSJ2 is a nucleolar RNA methyltransferase involved in eukaryotic RNA processing and modification. PMID: 11827451

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  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, RNA methyltransferase RlmE family
  • 組織特異性：
    Widely expressed, with highest expression in muscle, placenta, and heart.
  • 數據庫鏈接：

    HGNC: 16352

    OMIM: 606906

    KEGG: hsa:29960

    STRING: 9606.ENSP00000242257

    UniGene: Hs.279877



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