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Your Good Partner in Biology Research

MRGPRX1 Antibody

  • 中文名稱:
    MRGPRX1兔多克隆抗體
  • 貨號:
    CSB-PA290385
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA290385(MRGPRX1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA290385(MRGPRX1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    MRGPRX1; MRGX1; SNSR3; SNSR4; Mas-related G-protein coupled receptor member X1; Sensory neuron-specific G-protein coupled receptor 3/4
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human MRGPRX1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.
  • 基因功能參考文獻:
    1. MRGPRX1 is a promising target for pain inhibition, a humanized mouse model expressing this receptor has been described. PMID: 28223516
    2. Der p1 also induced the release of IL-6 from heterologous cells expressing MRGPRX1. In summary, activation of Mrgprs by the allergen Der p1 may contribute to inflammation. PMID: 28768771
    3. analysis of the functional interactions between MRGPR-X1 and TRPV1 PMID: 23074220
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family, Mas subfamily
  • 組織特異性:
    Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
  • 數據庫鏈接:

    HGNC: 17962

    OMIM: 607227

    KEGG: hsa:259249

    STRING: 9606.ENSP00000305766

    UniGene: Hs.711459



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