在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MRC1 Antibody

Rare Species
  • 中文名稱:
    MRC1兔多克隆抗體
  • 貨號:
    CSB-PA338680XA01SVG
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes: MRC1 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 51 kDa
      Observed band size: 51 kDa
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Mediator of replication checkpoint protein 1 (DNA replication checkpoint mediator MRC1) MRC1 YCL061C YCL61C/YCL60C
  • 反應種屬:
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 免疫原:
    Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MRC1 protein (711-851aa)
  • 免疫原種屬:
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Affinity-chromatography
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Required for normal DNA replication. Phosphorylated in response to DNA replication stress. Phosphorylation allows it to mediate the activation of RAD53.
  • 基因功能參考文獻:
    1. An unbiased kinome screening identified several kinases that phosphorylate Mrc1 at the N terminus upon different environmental stresses. PMID: 29371596
    2. Dia2-dependent degradation of Mrc1 is required for replication fork restart in a pathway that includes Sgs1 and Mph1. PMID: 27956499
    3. Disruption of MRC1 leads to consistently elevated expansion and contraction rates of CAG.CTG repeat tracts. PMID: 18321795
    4. Authors show that minisatellite length expansions are controlled by the products of the CSM3 and TOF1 genes, while contractions are controlled by MRC1. PMID: 23165348
    5. Whereas Ddc1 and Dpb11 aid in replication-checkpoint activation, colocalization of Mec1 and Mrc1 at stalled replication forks promotes Rad53 activation sufficient to stabilize the replisome during transient replication stress. PMID: 22298423
    6. Data show that that ISC1 controls cell morphology in combination with checkpoint regulators Swe1, Cdk1(CDC28), MRC1, TOF1, CSM3, RAD9 and Rad53. PMID: 21840863
    7. cells deleted of MRC1, a gene implicated in replication fork stabilization and in the replication checkpoint pathway, maintained wild-type firing times despite over twofold lengthening of S phase PMID: 20219942
    8. Data show that the Tof1/Csm3/Mrc1 checkpoint complex interacts directly with the MCM helicase during both replication fork progression and when the replication fork is stalled. PMID: 15755447
    9. Mrc1 functions constitutively to promote normal replication fork progression. PMID: 16137624
    10. Tof1p-Csm3p function differently from MRC1 and their complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae PMID: 16418273
    11. Mrc1 plays a specific role in DNA replication, promoting the Srs2 recruitment to proliferating cell nuclear antigen (PCNA) independently of checkpoint signaling. PMID: 16724109
    12. Mrc1 may negatively regulate Cdc45 and MCM helicase to render stalled forks capable of resuming replication. PMID: 16849602
    13. Study reports that in the absence of Mrc1, a component of the replication forks, telomeres of cdc13 or yku70 mutants exhibited increased degradation, while telomerase-negative cells displayed accelerated senescence. PMID: 17323081
    14. analyzed sister-chromatid cohesion in double mutants of mrc1Delta, tof1Delta, and csm3Delta and identified additive cohesion defects that indicated the existence of at least two pathways that contribute to sister-chromatid cohesion PMID: 17483413
    15. Mrc1 and Tof1 control the normal progression of DNA replication forks in distinct ways. PMID: 17652453
    16. In unperturbed cells, Mrc1 interacts independently with both the N-terminal and C-terminal halves of Pol2 (Pol2N and Pol2C). PMID: 18851837
    17. Data show that the replication checkpoint suppresses the formation of Rad52 foci in an Mrc1-dependent manner and prevents homologous recombination (HR) at chromosome breaks induced by the HO endonuclease. PMID: 19322196
    18. Rad53 is activated by Mec1 through adaptor protein Mrc1 PMID: 19457865
    19. Mec1-dependent, Rad53-independent phosphorylation of Mrc1 is required to establish a positive feedback loop that stabilizes Mec1 and the replisome at stalled forks. PMID: 19515819
    20. An Mcm helicase acts as a checkpoint sensor for methyl methanesulfonate-induced DNA damage through direct binding to the replication checkpoint mediator Mrc1. PMID: 19620285
    21. Csm3, Tof1, and Mrc1 form a heterotrimeric mediator complex that associates with DNA replication forks PMID: 19819872

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Associated with chromatin during S phase.
  • 數據庫鏈接:

    KEGG: sce:YCL061C

    STRING: 4932.YCL061C



主站蜘蛛池模板: 精品国产亚洲一区二区三区在线观看| 亚洲免费人成视频观看| 99久久无色码中文字幕人妻| 国产漂亮白嫩美女在线观看| 爆乳喷奶水无码正在播放| 日日夜夜撸啊撸| 国产乱人对白| 国产成人麻豆精品午夜福利在线| 好男人www社区视频在线资源| 国产精品无码av不卡顿| 国产精品一卡二卡三卡四卡| 99e久热只有精品8在线直播| 麻豆自媒体 一区 二区| 日本丰满少妇bbb| 欧美成人一区二区三区在线观看| 久久人人爽人人爽人人片av高请| 99久久久无码国产精品动漫| 成人无码精品免费视频在线观看| 夜精品a片一区二区三区无码白浆 漂亮人妻被中出中文字幕 | 欧美性受xxxx白人性爽| 成人免费看片又大又黄| 国产xxxx做受性欧美88| 最近日本mv字幕免费高清完整版| 中文国产成人精品久久app| 少妇无码av无码专区在线观看| 女人被黑人躁得好爽视频| 日本高清中文字幕免费一区二区| 亚洲国产精品久久久久久久| 久久不见久久见中文字幕免费| 国产综合有码无码视频在线| 天天影视性色香欲综合网| 亚洲色欲色欱www在线| 国产精品扒开腿做爽爽爽视频 | 日本真人做爰免费视频120秒| 久久国产欧美日韩精品图片| 国产 av 仑乱内谢| 少妇真人直播免费视频| 免费纯肉3d动漫无码网站| 亚洲经典国产精华液单品榜| 日韩v亚洲v欧美v精品综合| 国产黄a三级三级三级av在线看|