在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MRAP2 Antibody, Biotin conjugated

MRAP2 Antibody, Biotin conjugated

  • 中文名稱：
    MRAP2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA853421LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MRAP2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MRAP2
  • 別名：
    MRAP2; C6orf117; Melanocortin-2 receptor accessory protein 2; MC2R accessory protein 2
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Melanocortin-2 receptor accessory protein 2 protein (66-205AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo.
  • 基因功能參考文獻(xiàn)：
    1. The accepted idea that melanocortin Receptor Accessory Proteins (MRAPs) are specific regulators of melanocortin receptors was recently challenged by the discovery that MRAP2 inhibits the activity of prokineticin receptors. Recent studies are starting to explain the role of the unusual structure of MRAPs and to illustrate the importance of MRAP2 for the maintenance of both energy and glucose homeostasis. [review] PMID: 28499989
    2. In this study we demonstrate a new role of MRAP2 in the regulation of the orexin receptor 1 (OX1R) and identify the specific regions of MRAP2 required for the regulation of OX1R and PKR1. Importantly, like MC4R and PKRs, OX1R is predominately expressed in the brain where it regulates food intake PMID: 28939058
    3. This was the first study describing an effect of a MRAP2 mutation on mediated by regulation of the melanocortin-4 receptor FUNCTION IN HUMAN. PMID: 27474872
    4. no gene harboring deletions were identified in the SIM1 and MRAP2 regions in the Prader Willi like (PWL) cohort; further functional analysis of p.P352S found in SIM1 and p.A40S found in MRAP2 is useful; this would provide further support for possible role of SIM1 and MRAP2 in the pathogenesis of the PWL phenotype in a limited number of patients PMID: 26795956
    5. MC3R is a 2-exon gene that requires a 5' UTR for translation, localization, and potential interaction with MRAP2 PMID: 25051171
    6. In a study of humans with severe, early-onset obesity, they found four rare, potentially pathogenic genetic variants in MRAP2, suggesting that the gene may also contribute to body weight regulation in humans. PMID: 23869016
    7. Data suggest that MRAP2 regulates expression of melanocortin receptors (MC1R-MC5R); MRAP2 is highly expressed in fetal adrenal glands; MRAP2 is also expressed in hypothalamus, a site that expresses high levels of MC3R and MC4R. [REVIEW] PMID: 23418361
    8. MRAP2 is positively regulated by ACTH and AngII in human adrenocortical tissues. PMID: 22419722
    9. The MC2R/MRAP2 complex requires much higher concentrations of ACTH to activate compared with the MC2R/MRAP complex. PMID: 21367968
    10. MRAP2 is an endogenous inhibitor that competes with MRAP for binding to MC2R and decreases the potency of adrenocorticotropic hormone (ACTH). PMID: 20371771

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Obesity (OBESITY)
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    MRAP family
  • 組織特異性：
    Expressed in the adrenal gland and brain. Not expressed in other tissues.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 21232

    OMIM: 601665

    KEGG: hsa:112609

    STRING: 9606.ENSP00000257776

    UniGene: Hs.370055



主站蜘蛛池模板： 亚洲精品色情app在线下载观看| 亚洲日韩精品射精日| 草草影院精品一区二区三区| h无码精品3d动漫在线观看 | 中国少妇初尝黑人巨高清| 四虎影库久免费视频| 少妇无码一区二区三区免费| 久激情内射婷内射蜜桃| 国产亚洲日本精品成人专区| 在线|国产精品女主播阳台| 精品国模一区二区三区| 亚洲精品亚洲人成人网| 国产精品成人嫩草影院| 免费人成网站在线观看视频| 综合亚洲桃色第一影院| 少妇扒开粉嫩小泬视频| 国产区精品系列在线观看| 亚洲手机在线人成网站| 亚洲精品一区久久久久久| 国产精品美女一区二区视频| 精品久久一区二区乱码| 99精品久久久久中文字幕| 国产吃奶在线观看| 熟女内射v888av| 精品人妻少妇嫩草av无码专区| 欧美极p品少妇的xxxxx| 亚洲欧美国产va在线播放 | 国产在线拍揄自揄拍免费下载 | 性色av极品无码专区亚洲| 欧美饥渴熟妇高潮喷水| 久久综合给合久久97色| 无码丰满熟妇| 亚洲国产精品久久久久婷婷软件| 欧美人与动性行为视频| 国产情侣一区二区| 大地资源网第二页免费观看| 亚洲高清乱码午夜电影网| 国产 日韩 另类 视频一区| 久久精品国产亚洲7777| 亚洲成a人片在线观看高清| 成人爽a毛片免费看|