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MPEG1 Antibody

  • 中文名稱：
    MPEG1兔多克隆抗體
  • 貨號：
    CSB-PA642654LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of A549 cells with CSB-PA642654LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MPEG1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    macrophage expressed 1 antibody; Macrophage expressed gene 1 antibody; Macrophage gene 1 protein antibody; Macrophage specific gene 1 antibody; Macrophage-expressed gene 1 protein antibody; Mpeg1 antibody; MPEG1_HUMAN antibody; Mpg-1 antibody; Mpg1 antibody; MPS1 antibody; MSG antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Macrophage-expressed gene 1 protein (537-633AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，MPEG1 Antibody (CSB-PA642654LA01HU)，的標記方式是Non-conjugated。對于MPEG1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA642654LB01HU MPEG1 Antibody, HRP conjugated ELISA
    FITC CSB-PA642654LC01HU MPEG1 Antibody, FITC conjugated
    Biotin CSB-PA642654LD01HU MPEG1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a key role in the innate immune response following bacterial infection by inserting into the bacterial surface to form pores. By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence. Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide.
  • 基因功能參考文獻：
    1. these data provide the evidence that membrane-bound and secretory isoforms of perforin-2 are present in human macrophages and may play important roles in immune defense PMID: 28705375
    2. Collectively, these studies further underscore the biological significance of Perforin-2 and elucidate critical molecular events that culminate in Perforin-2-dependent killing of both intracellular and extracellular, cell-adherent bacteria. PMID: 26418746
    3. the impact of Perforin-2/macrophage-expressed protein 1 from the earliest multicellular organisms to modern vertebrates, as well as review the development of other membrane attack complexes of complement and Perforin domain member proteins PMID: 26307549
    4. Knockdown of perforin-2 in macrophages did not alter the invasion of host cells but did result in chlamydial growth that closely mirrored that detected in HeLa cells. PMID: 23753625
  • 亞細胞定位：
    [Isoform 1]: Cytoplasmic vesicle membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 組織特異性：
    Expressed constitutively in a variety of cell types including macrophages, natural killer cells, neutrophils, keratinocytes and monocytes. In skin, expressed in both hematopoietic and non-hematopoietic cells with expression detected in a variety of cell t
  • 數據庫鏈接：

    HGNC: 29619

    OMIM: 610390

    KEGG: hsa:219972

    STRING: 9606.ENSP00000354335

    UniGene: Hs.744920



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