在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MORF4L1 Antibody

MORF4L1 Antibody

  • 中文名稱：
    MORF4L1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA883368ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: Mortality factor 4-like protein 1 antibody at 2μg/ml + A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 42, 38, 27 kDa
      Observed band size: 42 kDa
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA883368ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MORF4L1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MORF4L1
  • 別名：
    CG6363 antibody; Eaf3 antibody; Esa1p associated factor 3 homolog antibody; FWP006 antibody; HsT17725 antibody; MEAF3 antibody; MO4L1_HUMAN antibody; MORF related gene on chromosome 15 antibody; MORF-related gene 15 protein antibody; Morf4l1 antibody; MORFRG15 antibody; Mortality factor 4 like 1 antibody; Mortality factor 4 like protein 1 antibody; Mortality factor 4-like protein 1 antibody; MRG15 antibody; Protein MSL3-1 antibody; S863-6 antibody; Transcription factor-like protein MRG15 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Mortality factor 4-like protein 1 protein (1-100AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
  • 基因功能參考文獻(xiàn)：
    1. PALB2 associates with active genes through its major binding partner, MRG15, which recognizes histone H3 trimethylated at lysine 36 (H3K36me3) by the SETD2 methyltransferase PMID: 28673974
    2. Both MRG15 CD and Pf1 PHD1 bind to their targets with >100 muM affinity. PMID: 22728643
    3. While the present study expands on the role of MRG15 in the control of genomic stability, weak associations can not be ruled out for potential low-penetrance variants at MORF4L1 and breast cancer risk among BRCA2 mutation carriers PMID: 21466675
    4. it seems unlikely that any constitutional changes in MRG15 confer an increased risk for breast cancer. PMID: 20844547
    5. gene deficiency reduces DNA repair and increase sensitivity to DNA-crosslinking agents PMID: 20332121
    6. a novel chromodomain protein that is present in two distinct multiprotein complexes involved in transcriptional activation PMID: 12397079
    7. Site-directed mutagenesis studies of a prototypic MRG domain from human MRG15 based on the X-ray structure and bioinformatics identify key residues involved in the binding of PAM14 and MRGBP. PMID: 16407074
    8. identify MRG15 residues that form a shallow hydrophobic pocket to interact with the N-terminal 50 residues of PAM14 through primarily hydrophobic interactions PMID: 17008723
    9. The MRG15 chromo domain may function as an adaptor module which can bind to a modified histone H3 in a mode different from that of the HP1/Pc chromo domains. PMID: 17135209
    10. MORF4 has a role in cellular aging, and MRG15 associates with both histone deacetylases and histone acetyl transferase complexes [review] PMID: 17460191
    11. RBP2 associates with MRG15 complex to maintain reduced H3K4 methylation at transcribed regions, which may ensure the transcriptional elongation state PMID: 17573780
    12. MRG15 is a novel PALB2-interacting factor involved in homologous recombination PMID: 19553677

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 16989

    OMIM: 607303

    KEGG: hsa:10933

    STRING: 9606.ENSP00000331310

    UniGene: Hs.374503



主站蜘蛛池模板： 国内女人喷潮完整视频| 亚洲精品一区| 天堂中文最新版在线官网在线| 久久精品动漫一区二区三区| 色五月丁香五月综合五月4438| 国产精品人成视频国模| 久久亚洲精品无码播放| 国产超碰无码最新上传| 特级小箩利无码毛片| 激情国产av做激情国产爱| 精品一区二区三区在线视频| 国产精品国产高清国产av| 熟妇人妻无码中文字幕老熟妇| 国产福利在线视频蜜芽tv| 欧洲精品va无码一区二区三区| 亚洲大码熟女在线| 亚洲精品成人区在线观看 | 毛片免费观看天天干天天爽| 亚洲欧美成人一区二区在线| 国产av天堂亚洲国产av天堂| 中国亚洲女人69内射少妇| 国产成人综合久久精品推下载| 亚洲国产日韩一区三区| 国产卡一卡二卡三精品| 国产人妻精品午夜福利免费| 久久这里只精品国产免费10| 国产精品无码av片在线观看播| 精产国品一二三产品麻豆| 人人妻人人澡av天堂香蕉| 18禁裸男晨勃露j毛免费观看| 国产福利精品一区二区| 亚洲欧洲日产韩国在线看片| av无码国产在线看免费网站| 国产精品久久国产精品99| 国产无遮挡无码视频免费软件| 亚洲午夜无码极品久久| 激情综合五月丁香亚洲| 军人粗大的内捧猛烈进出视频| 丁香花在线影院观看在线播放 | 西西人体扒开下部试看120秒| 同性女女黄h片在线播放|