在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MOCS3 Antibody, FITC conjugated

  • 中文名稱:
    MOCS3兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA014707LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MOCS3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MOCS3
  • 別名:
    Adenylyltransferase and sulfurtransferase MOCS3 (Molybdenum cofactor synthesis protein 3) (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase) [Includes: Molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) (Adenylyltransferase MOCS3) (Sulfur carrier protein MOCS2A adenylyltransferase), Molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) (Sulfur carrier protein MOCS2A sulfurtransferase) (Sulfurtransferase MOCS3)], MOCS3, UBA4
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Adenylyltransferase and sulfurtransferase MOCS3 protein (279-404aa)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.
  • 基因功能參考文獻:
    1. This observation should encourage testing of additional intellectual disability patients with mild abnormalities of sulfite metabolism for MOCS3 mutations. PMID: 28544736
    2. Among the associated variants were two in regions previously unreported for COPD; a low frequency non-synonymous SNP in MOCS3 (rs7269297, pdiscovery=3.08x10(-6), preplication=0.019) and a rare SNP in IFIT3, which emerged in the meta-analysis (rs140549288, pmeta=8.56x10(-6)). PMID: 26917578
    3. ubiquitin-like Urm1.Uba4 systems are conserved and exchangeable between human and yeast cells PMID: 25747390
    4. extension of the C terminus with an additional glycine of MOCS2A and URM1 altered the localization of MOCS3 from the cytosol to the nucleus. PMID: 22453920
    5. MOCS3 protein is believed to catalyze both the adenylation and the subsequent generation of a thiocarboxylate group at the C terminus of the smaller subunit of molybdopterin synthase PMID: 15073332
    6. Electrospray ionization mass spectrometry performed on a rhodanese-like carboxyl-terminal domain of human MOCS3 provides direct evidence for the formation of persulfide on cysteine residue 412. PMID: 15910006
    7. in humans & most eukaryotes thiosulfate is not physiologic sulfur donor for MOCS3, whereas in bacterial homologs, which have arginine at last position of active site loop, thiosulfate can be used as a sulfur source for molybdenum cofactor biosynthesis. PMID: 17459099
    8. The UBA4-URM1 system represents the evolutionary link between protein conjugation and protein modification by sulfur carrier proteins. PMID: 18491921
    9. Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis PMID: 18650437

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    HesA/MoeB/ThiF family, UBA4 subfamily
  • 數據庫鏈接:

    HGNC: 15765

    OMIM: 609277

    KEGG: hsa:27304

    STRING: 9606.ENSP00000244051

    UniGene: Hs.159410



主站蜘蛛池模板: 国产精品无需播放器在线观看| 又色又爽又黄的gif动态图| 亚洲一区日韩高清中文字幕亚洲 | 天天摸夜夜摸夜夜狠狠添| 亚洲国产精品自在拍在线播放蜜臀 | 夜夜澡人摸人人添人人看 | 亚洲欧洲国产成人综合在线观看 | 高h纯肉无码视频在线观看| 亚洲国产成人久久综合三区| 狠狠色噜噜狠狠狠888777米奇| 四虎精品免费永久免费视频| www亚洲精品少妇裸乳一区二区 | 国产成人综合亚洲精品| 色哟哟免费视频播放网站| 伊人久久大香线蕉无码| 国产人妻丰满熟妇嗷嗷叫| 亚洲综合色噜噜狠狠网站超清| 国产老太睡小伙子视频| 欧美性受xxxx狂喷水| 俺也来俺也去俺也射| 在线成人a毛片免费播放 | 国产精品老汉av| 国产成人午夜福利电影在线播放| 初尝黑人巨砲波多野结衣| 乱色熟女综合一区二区三区| 中文字幕亚洲无线码一区女同| 成人影院永久免费观看网址| 久久久久久人妻精品一区| 国产乱人激情h在线观看| 四虎成人精品无码永久在线| 强制高潮18xxxx按摩| 亚洲一区二区av在线观看| 18禁高潮出水呻吟娇喘蜜芽| 尤物yw193无码点击进入| 人人爽人人爽人人片av东京热| 影视av久久久噜噜噜噜噜三级| 无码人妻人妻经典| 成人亚洲欧美成αⅴ人在线观看 | 精品国产乱码久久久久软件| 国产乱人伦偷精品视频下| 久久人妻少妇嫩草av|