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  4. MNDA Antibody

MNDA Antibody

  • 中文名稱：
    MNDA兔多克隆抗體
  • 貨號：
    CSB-PA010214
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 3T3 cells using MNDA Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    MNDA
  • 別名：
    MNDA antibody; MNDA_HUMAN antibody; Myeloid cell nuclear differentiation antigen antibody; OTTHUMP00000024384 antibody; PYHIN3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human MNDA.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
  • 基因功能參考文獻(xiàn)：
    1. MFC adds significant information on dyspoiesis in the diagnostic work up for MDS and provides prognostic information. MNDA expression can be assessed by MFC and may facilitate evaluation of dyspoiesis when added to MDS MFC panels. PMID: 26184452
    2. MNDA expression is an independent marker for the evaluation of dyspoiesis and may be added to the standard panel for quantitative assessment by FCM. PMID: 26822549
    3. Studied the HIN domain of recombinant myeloid nuclear differentiation antigen (MNDA). PMID: 24557068
    4. these data support the inclusion of MNDA in the diagnostic evaluation of extramedullary B-cell lymphomas, particularly those in which the differential diagnosis is between low-grade follicular lymphoma and marginal zone lymphoma. PMID: 24925224
    5. Myeloid antigen expression is a predictor of a poor response to chemotherapy, and an adverse prognostic factor in adult T-lymphoblastic lymphoma, but not in children with T-LBL. PMID: 20193116
    6. Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression PMID: 12112016
    7. variation in MNDA expression appeared to change with phenotypic specialization of monocytes in atherosclerosis consistent with its association with inflammation and suspected roles in regulating gene expression or in mediating cell death PMID: 15778972
    8. MNDA has a role regulating programmed cell death in myeloid progenitor cells, and that its down-regulation in myelodysplastic syndromes is related to granulocyte-macrophage progenitor cell sensitivity to TRAIL-induced programmed cell death. PMID: 16651415
    9. MNDA expression is a useful tool for the recognition of nodal marginal zone lymphoma PMID: 19474799

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  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm. Note=Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.
  • 組織特異性：
    Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appears in myeloblast cells in some cases of acute myeloid Leukemia
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7183

    OMIM: 159553

    KEGG: hsa:4332

    STRING: 9606.ENSP00000357123

    UniGene: Hs.153837



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