在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MMP15 Antibody

  • 中文名稱:
    MMP15兔多克隆抗體
  • 貨號:
    CSB-PA032714
  • 規格:
    ¥1100
  • 圖片:
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA032714(MMP15 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    MMP15
  • 別名:
    MMP15; Matrix metalloproteinase-15; MMP-15; Membrane-type matrix metalloproteinase 2; MT-MMP 2; MTMMP2; Membrane-type-2 matrix metalloproteinase; MT2-MMP; MT2MMP; SMCP-2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human MMP15
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:200-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
  • 基因功能參考文獻:
    1. identify an MT2-MMP-E-cadherin axis that functions as a novel regulator of epithelial cell homeostasis in vivo PMID: 29061881
    2. Results suggest that MT2-MMP degrades adherens and tight junction proteins and results in EMT, making it a potential mediator of EMT in carcinomas. PMID: 27374080
    3. TCF-4 is a co-activator of NF-kappaB p65 that promotes MMP-15 transcription and potentiate the migration activity of the lung cancer cells PMID: 27046058
    4. In conclusion, MT2-MMP is involved in gastric cancer invasion and metastasis and may serve as an independent prognostic factor for gastric cancer patients. PMID: 25973093
    5. our data suggest that MT2-MMP expression positively involves in non-small cell lung cancer and might play an important role in promoting the tumor progression and intra-tumoral angiogenesis PMID: 25031779
    6. HLA-G expression involved in tumor invasiveness or metastasis may rely on the NK cytotoxicity inhibition and induction of MMP-15 expression in ovarian cancer. PMID: 23228395
    7. MMP-15 is up-regulated in preeclampsia, but does not cleave endoglin to produce soluble endoglin. PMID: 22768148
    8. MMP-15 and MMP-19 are upregulated during colorectal tumorigenesis PMID: 22576687
    9. Data show that MT2-MMP was a novel hypoxia-responsive gene and was upregulated by HIF-1alpha under hypoxia. PMID: 21751260
    10. The intensity of immunochemical staining of MT2-MMP was significantly positively correlated to the intratumoral angiogenesis of esophageal cancer tissues. PMID: 21036765
    11. MMP2 activity is associated with an increase in MT2-MMP expression and with lymph node metastasis. PMID: 20586027
    12. These results indicate MT2-MMP might be involved in the cancer progression more than or equal to MT1-MMP independently of MMP-2 and MT1-MMP. PMID: 20117087
    13. Data show that the MT2-MMP catalytic domain has a higher propensity than that of MT1-MMP to initiate cleavage of the MMP-2 prodomain in the absence of TIMP-2. PMID: 16825197
    14. Type-2 metalloproteinases, are identified as the triggering agents that independently confer cancer cells with the ability to proteolytically efface the BM scaffolding, initiate the assembly of invasive pseudopodia, and propagate transmigration. PMID: 16983145
    15. Data show that MMP15 may be relevant with carcinogenesis, development and metastasis of adenoid cystic carcinoma, and different metastasis potential may result from different subtype of MMPs gene family. PMID: 17029196

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein; Extracellular side.
  • 蛋白家族:
    Peptidase M10A family
  • 組織特異性:
    Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
  • 數據庫鏈接:

    HGNC: 7161

    OMIM: 602261

    KEGG: hsa:4324

    STRING: 9606.ENSP00000219271

    UniGene: Hs.80343



主站蜘蛛池模板: 寂寞人妻瑜伽被教练日| 米奇影视第四色| 亚洲国产精品不卡av在线| 久久精品人成免费| 18禁超污无遮挡无码免费网站国产 | 天堂8在线天堂资源bt| 黑森林福利视频导航| 少妇无码av无码专区线| 欧美综合乱图图区乱图图区| 人妻熟女一区二区aⅴ清水理纱 | 日韩人妻少妇一区二区三区| 少妇av射精精品蜜桃专区| 成人亚洲精品久久久久软件| 青青草国产精品免费观看| 国产放荡对白视频在线观看| 国产成人无码短视频| 人妻体内射精一区二区三区| 少妇高潮无套内谢| 日韩午夜理论免费tv影院| 人妻熟妇乱又伦精品视频| 中文字幕爆乳julia女教师| 欧美成人一区二区三区| 日韩美女自卫慰黄网站| 国产精品嫩草影院永久…| 99精品欧美一区二区三区 | 久久99国产只有精品| 天堂在/线资源中文在线8 | 精品国产高清自在线一区二区| 男女啪啪进出阳道猛进| 欧美一区二区三区久久综合| 国产情侣大量精品视频| 国产 | 欧洲野花视频天堂视频p| 吸咬奶头狂揉60分钟视频| 俄罗斯大荫蒂女人毛茸茸 | 亚洲成_人网站图片| 亚洲综合色成在线播放| 激情偷乱人成视频在线观看| 亚洲精品四区麻豆文化传媒| 裸身美女无遮挡永久免费视频 | 狠狠久久久久综合成人影院| 老子影院午夜伦手机不四虎卡|