在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MLLT4 Antibody

  • 中文名稱:
    MLLT4兔多克隆抗體
  • 貨號:
    CSB-PA014636GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    AF6 antibody; AFAD_HUMAN antibody; Afadin antibody; ALL1-fused gene from chromosome 6 protein antibody; Mllt4 antibody; Protein Af-6 antibody; Protein AF6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human MLLT4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions.
  • 基因功能參考文獻:
    1. CLDN6 enhances the chemoresistance to ADM via activating the AF-6/ERK signaling pathway and up-regulating cancer stem cell characters in MDAMB231 cells. PMID: 29159771
    2. AF6 employs a non-canonical, evolutionarily conserved alpha-helix to bind RAS, unique to AF6 and the classical RASSF effectors. PMID: 29062045
    3. miR-188-3p is a novel independent prognostic factor in colorectal cancer patients, which can be partly explained by its effect on MLLT4 expression and migration of cancer cells. PMID: 27601590
    4. Afadin (AFDN), a cytoskeletal and junction-associated protein, was present in 2D and 3D keratinocyte cultures, and validated as a so-far-unknown EphA2-interacting protein. PMID: 27815408
    5. In pancreatic cancer cells, AF6 is expressed at reduced levels, causing Dvl2 to be upregulated and available to bind and enhance FOXE1-induced trans-activation of Snail, which promotes proliferation and metastasis. PMID: 26013125
    6. AF-6/afadin could be a useful selection marker for fertility-sparing therapy for patients with atypical hyperplasia or grade 1 endometrioid adenocarcinoma with no myometrial invasion. PMID: 25879875
    7. JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton. PMID: 23885123
    8. The expression levels of CFTR and AF-6/afadin are significantly downregulated in human colon cancer tissues. PMID: 24373847
    9. AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease. PMID: 23393160
    10. The interaction between the PDZ domain of afadin (AF6_PDZ) and a series of polypeptides comprising the PDZ-binding motif, was studied. PMID: 20586101
    11. Results demonstrate a role for afadin in the regulation of vascular barrier function via coordination of adherens junction-tight junction and p120-catenin-ZO-1 interactions. PMID: 21732359
    12. the Necl-5-nectin, nectin-nectin, and nectin-afadin interactions cooperatively increase the clustering of the nectin-afadin complex at the cell-cell contact sites, promoting the formation of the nectin-based cell-cell adhesion. PMID: 21880730
    13. AF6/afadin is a marker of poor outcome in breast cancer, and its loss induces cell migration, invasiveness and tumor growth PMID: 21478912
    14. Results demonstrate a novel molecular mechanism by which Rap1 and afadin regulate the VEGF- and S1P-induced angiogenesis. PMID: 20413783
    15. RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6. PMID: 11956217
    16. Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain PMID: 12808105
    17. Results report the solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr. PMID: 15684424
    18. AF6 negatively regulates Rap1-induced cell adhesion. PMID: 16051602
    19. Loss of afadin is associated with breast cancer PMID: 16819513
    20. AF6/s-afadin is a candidate for mediating control of cellular growth processes by regulated translocation to the nucleus. PMID: 17013812
    21. c-Src is recruited by AF-6 to cell-cell contact sites, suggesting that c-Src is regulated by a PDZ protein in special cellular locations. PMID: 17491594
    22. AF6 protein is important for spreading of Herpes simplex virus 1 in epithelial cells PMID: 17967423
    23. two distal surfaces of the AF-6 PDZ domain respond differently to peptide binding; distal surface 1 changes in millisecond dynamics, whereas distal surface 2 undergoes structural rearrangement PMID: 18052198
    24. This paper deals with AF-6 in mouse, rat, and cow. PMID: 9722616

    顯示更多

    收起更多

  • 相關疾病:
    A chromosomal aberration involving AFDN is associated with acute leukemias. Translocation t(6;11)(q27;q23) with KMT2A/MLL1. The result is a rogue activator protein.
  • 亞細胞定位:
    Cell junction, adherens junction.
  • 數據庫鏈接:

    HGNC: 7137

    OMIM: 159559

    KEGG: hsa:4301

    STRING: 9606.ENSP00000375956

    UniGene: Hs.614974



主站蜘蛛池模板: 亚洲日韩欧美一区二区三区在线| 老女老肥熟国产在线视频| 99精品全国免费观看视频| 久久精品国产99久久6| 性欧美vr高清极品| 中国女人内射6xxxxx| 亚洲人成网站在线播放小说 | 在线精品无码字幕无码av| 午夜免费男女aaaa片| 四川丰满妇女毛片四川话| 18禁免费观看网站| 国产精品一区二区香蕉| 天堂在线www资源在线| av在线播放日韩亚洲欧我不卡| 妺妺窝人体色www看人体| 极品少妇被啪到呻吟喷水| 色综合色综合久久综合频道88 | 久久精品国产亚洲一区二区| 乱人伦无码中文视频在线| 中日精品无码一本二本三本| 国产在线观看无码免费视频| 亚洲精品乱码久久久久久久久久久久 | 日本www一道久久久免费| 国产亚洲精品自在久久蜜tv| 香蕉久久国产av一区二区| 国产无遮挡无码视频免费软件| 欧美xxxx做受欧美1314| 最近中文字幕mv在线视频看 | 欧美熟妇xxxxx欧美老妇不卡 | 免费国产va在线观看中文字| 毛片无码免费无码播放| 欧美日本国产va高清cabal| 国产精品狼人久久久久影院 | 国产免费啪嗒啪嗒视频看看 | 在线资源天堂www| 人人妻人人澡av天堂香蕉| 超清中文乱码字幕在线观看 | 亚洲 欧美 日韩 综合aⅴ视频| 国产精品久久久久野外| 欧美 国产 亚洲视频| 成人h无码动漫超w网站|