在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MLLT10 Antibody

  • 中文名稱:
    MLLT10兔多克隆抗體
  • 貨號(hào):
    CSB-PA578091
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from COLO205 cells and Jurkat cells, using AF10 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MLLT10 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MLLT10
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human AF10.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation.
  • 基因功能參考文獻(xiàn):
    1. In vitro, the overexpression of MLLT10 promoted colorectal cancer (CRC) cell migration and invasion, while after MLLT10 was knocked down, the opposite results were observed. In lung metastasis sites, the knockdown of MLLT10 in SW620 cells significantly inhibited Vimentin expression, whereas the E-Cadherin was increased. These results indicate that MLLT10 regulates the metastasis of CRC cells via EMT. PMID: 30102091
    2. In a retroviral transduction/transplantation mouse model, mice transplanted with MLL/AF10(OM-LZ) cells harboring PTPN11(wt) developed myelomonocytic leukemia. Those transplanted with cells harboring PTPN11(G503A) -induced monocytic leukemia in a shorter latency. Adding PTPN11(G503A) to MLL/AF10 affected cell proliferation, chemo-resistance, differentiation, in vivo BM recruitment/clonal expansion and faster progression. PMID: 27859216
    3. Our results provide evidence for new loci influencing abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2) previously reported to be associated with abdominal fat in women PMID: 26480920
    4. The PZP domain of AF10 senses unmodified H3K27 to regulate DOT1L-mediated methylation of H3K79. PMID: 26439302
    5. we report that variants at the MLLT10 locus are unlikely to alter risk of glioma, and they have no prognostic value among patients with high-grade tumors (glioblastoma). PMID: 24755950
    6. Results provide evidence that transformation driven by MLL fusions as well as the recurrent AML-associated NUP98-NSD1 fusion oncogene is critically dependent on the ability of AF10 to stimulate DOT1L activity. PMID: 25464900
    7. detection of PICALM-MLLT10 fusion transcript occurs in 7% of children with T-lineage ALL and is not associated with a poorer outcome for patients treated with contemporary, intensive chemotherapy PMID: 23670296
    8. In pediatric T-acute lymphoblastic leukemia, we have identified 2 RNA processing genes, that is, HNRNPH1/5q35 and DDX3X/Xp11.3 as new MLLT10 fusion partners. PMID: 23673860
    9. results strongly indicate that the differential regulation of these three genes is not due to the break point effect but as a consequence of the CALM/AF10 fusion gene expression, though the mechanism of regulation is not well understood PMID: 22064352
    10. In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin PMID: 21706055
    11. a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 x 10(-14)) was identified. PMID: 21804547
    12. FISH analysis in infant AML-M5 showed a complex rearrangement between chromosomes 10 and 11, disrupting the MLL gene, a paracentric inversion of the 11q13-q23 fragment translocated to 10p12. AF10 was the fusion partner gene of MLL in this rearrangement. PMID: 12127405
    13. ALL1 is involved in remodeling, acetylating, deacetylating, and methylating nucleosomes and/or free histones PMID: 12453419
    14. data reveal new properties for the leucine zipper domain and thus might provide new clues to understanding the mechanisms by which AF10 fusion proteins in which the PHD domain is lost might trigger leukemias in humans PMID: 12482966
    15. The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: MLL/AF10. PMID: 16215946
    16. Data show that the nuclear isoform of FLRG lacks an intrinsic transactivation domain, but enhances AF10-mediated transcription, probably through promoting the homo-oligomerization of AF10, thus facilitating the recruitment of co-activators. PMID: 17868029
    17. CALM(PICALM)/AF10 fusion protein might interfere with normal Ikaros (IKZF1)function, and thereby block lymphoid differentiation in CALM/AF10 positive leukemias. PMID: 18037964
    18. the CALM-AF10 fusion protein can also greatly reduce global H3K79 methylation in both human and murine leukemic cells by disrupting the AF10-mediated association of hDOT1L with chromatin PMID: 19443658

    顯示更多

    收起更多

  • 相關(guān)疾病:
    A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein.; DISEASE: Note=A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.
  • 亞細(xì)胞定位:
    Nucleus.
  • 組織特異性:
    Expressed abundantly in testis.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 16063

    OMIM: 602409

    KEGG: hsa:8028

    STRING: 9606.ENSP00000307411

    UniGene: Hs.30385



主站蜘蛛池模板: 日韩免费码中文在线观看| 精品三级久久久久电影网| 18禁无遮挡肉动漫在线播放观看| 无码人妻专区免费视频| 99久久精品国产免费| 日韩毛片无码永久免费看| 无码国产69精品久久久久孕妇| 精品久久久久久亚洲综合网| 亚洲性av免费| 亚洲日韩欧美国产另类综合| 丰满少妇被猛烈进入av久久| 国产99久久精品一区二区| 香蕉av777xxx色综合一区| 97精品一区二区视频在线观看| 成人看片黄a免费看在线| 国产成人精品永久免费视频| 小12箩利洗澡无码视频网站| 女人脱了内裤趴开腿让男躁| 艳妇乳肉豪妇荡乳| 很黄很色的动态图580期| 欧美日韩人成视频在线播放| а√天堂8资源在线官网| 精品国产一区二区三区av性色| 色老久久精品偷偷鲁| 尤物av无码国产在线看| 无人区一线二线三线乱码| 久久久久av无码免费网| 日本乱人伦在线观看| 久久精品人人槡人妻人| 午夜肉伦伦影院| 无码日韩精品一区二区免费暖暖 | 国内偷窥一区二区三区视频| 美女又色又爽视频免费| 中文人妻熟女乱又乱精品| 亚洲一区 日韩精品 中文字幕| 午夜美女裸体福利视频| 亚洲成av人片在线观看一区二区三区 | 久久精品国产99久久6| 亚洲国产成人综合精品| 亚洲va中文字幕无码久久| 少妇性荡欲视频|