在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MLF1 Antibody

  • 中文名稱:
    MLF1兔多克隆抗體
  • 貨號(hào):
    CSB-PA583476
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HUVEC cells, using MLF1 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MLF1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MLF1
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human MLF1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
  • 基因功能參考文獻(xiàn):
    1. Mutation in HTT causes Huntington's disease (HD); aggregates of mutated HTT cause apoptosis in neurons of HD patients. Data suggest that both MLF1 and MLF2 preferentially interact with mutated N-terminal HTT; MLF1/MLF2 reduce number of neurons (Neuro2A cell line) containing mutant HTT aggregates and subsequent apoptosis. (HTT = Huntingtin protein; MLF = myeloid leukemia factor) PMID: 27840155
    2. The data indicate that MLF1 serves as a proapoptotic antagonist that interacts with the HAX1/HtrA2-OMI/PARL (HOP) mitochondrial complex to modulate cell survival. PMID: 28137643
    3. These findings suggest that MLF and the associated co-chaperones play a direct role in modulating gene transcription. PMID: 27984043
    4. SNP associated with neuroblastoma resides upstream of the MLF1. Gene silencing of MLF1 in neuroblastoma cells results in significant growth inhibition. PMID: 28545128
    5. Data indicte that acute myeloid leukemia (AML) with NPM1-MLF1 and AML with NPM1 mutations showed similar immunophenotypical and molecular features, including gene mutation patterns and gene expression profiling (GEP). PMID: 23403313
    6. The subcellular localization of full-length human MLF1 is 14-3-3epsilon-independent. PMID: 23271436
    7. changes in the subcellular localization of NPM, due to alterations in the relative abundance of NPM and NPM-MLF1 proteins, may contribute to the enhanced myeloid progenitor activity of Npm +/- cells PMID: 22193965
    8. Data present the high-resolution crystal structure of this binding motif [MLF1(29-42)pSer34] in complex with 14-3-3epsilon and analyse the interaction with isothermal titration calorimetry. PMID: 22151054
    9. MLF1 gene rearrangement is associated with acute myeloid leukemia. PMID: 20471513
    10. phosphorylation of 14-3-3 binding site by MADM PMID: 12176995
    11. These findings suggest that an NPM/MLF1 fusion is the primary molecular abnormality in t(3;5) MDS and AML with multilineage dysplasia, and that cases with NPM/MLF1 may be clinically distinct from other MDS-associated disease PMID: 14506644
    12. Over-expression of MLF1 has little impact on skeletal muscle function in mice; progressive formation of protein aggregates in muscle are not necessarily pathogenic; MLF1 and MRJ may function together to ameliorate the toxic effects of mutant proteins. PMID: 17854834
    13. shuttling of MLF1 is critical for the regulation of cell proliferation and a disturbance in the shuttling balance increases the cell's susceptibility to oncogenic transformation PMID: 17967869

    顯示更多

    收起更多

  • 相關(guān)疾病:
    A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM.
  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族:
    MLF family
  • 組織特異性:
    Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 7125

    OMIM: 601402

    KEGG: hsa:4291

    UniGene: Hs.85195



主站蜘蛛池模板: 国产美女嘘嘘嘘嘘嘘| 麻豆av福利av久久av| 久久欧美国产伦子伦精品| 伊人久久大香线蕉av最新| 精品国产第一福利网站| 老熟妇性老熟妇性色| 亚洲精品成人无码中文毛片不卡| 国产乱码日产精品bd| 国产亚洲欧美日韩在线观看一区| 欧洲精品免费一区二区三区 | 女人高潮流白浆视频| 潮喷大喷水系列无码视频| 热99re久久国超精品首页| 色婷婷综合缴情综免费观看| 欧美老熟妇乱大交xxxxx| 成人无码a片一区二区三区免| 日本毛茸茸的丰满熟妇| 人妻无码专区一区二区三区| 久久精品无码专区免费| 国产中文字幕乱人伦在线观看| 亚洲欧洲日产国码中文字幕| 最新亚洲中文字幕在线观看| 欧美又粗又大xxxxbbbb疯狂| 欧美国产日韩a在线视频| 亚洲午夜成人精品无码app| 中文字幕亚洲综合久久蜜桃| 久久亚洲一区二区三区四区| 精品亚洲一区二区三区在线播放| 亚洲成av人片在www鸭子| 国产啪精品视频网站| 日韩超碰人人爽人人做人人添| 亚洲乱码无人区卡1卡2卡3| 欧美 日韩 国产 另类 图片区| 精品国产制服丝袜高跟| 亚洲中文字幕精品久久| 国产亚洲精品岁国产微拍精品| 精品亚洲成a人无码成a在线观看| 亚洲色欲久久久久综合网| 久久綾合久久鬼色88| 97精品超碰一区二区三区| 美女张开腿让男人桶爽|