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  4. MKLN1 Antibody, Biotin conjugated

MKLN1 Antibody, Biotin conjugated

  • 中文名稱：
    MKLN1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA890926LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MKLN1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MKLN1
  • 別名：
    MKLN 1 antibody; Mkln1 antibody; MKLN1_HUMAN antibody; muskelin 1, intracellular mediator containing kelch motifs antibody; Muskelin antibody; TWA2 antibody; Two-hybrid-associated protein with Ranbpm 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Muskelin protein (488-614AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1.
  • 基因功能參考文獻：
    1. A meta-analysis genome wide association study suggest MKLN1 is associated with early-onset bipolar disorder. PMID: 27769005
    2. RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and p44CTLH form complexes in cells PMID: 17467196
    3. These novel findings identify a role for muskelin-RanBP9 complex in pathways that integrate cell morphology regulation and nucleocytoplasmic communication. PMID: 18710924
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytosol. Nucleus, nucleoplasm. Cell projection, ruffle. Cytoplasm, cell cortex. Cell junction, synapse. Cell junction, synapse, postsynapse.
  • 數據庫鏈接：

    HGNC: 7109

    OMIM: 605623

    KEGG: hsa:4289

    STRING: 9606.ENSP00000323527

    UniGene: Hs.44693



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