在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MINA Antibody

MINA Antibody

  • 中文名稱：
    MINA兔多克隆抗體
  • 貨號：
    CSB-PA013829GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    RIOX2
  • 別名：
    60S ribosomal protein L27a histidine hydroxylase antibody; Bifunctional lysine specific demethylase and histidyl hydroxylase MINA antibody; FLJ14393 antibody; Histone lysine demethylase MINA antibody; MDIG antibody; MINA antibody; MINA_HUMAN antibody; Mineral dust-induced gene protein antibody; Myc induced nuclear antigen 53 kDa antibody; MYC induced nuclear antigen antibody; MYC-induced nuclear antigen antibody; NO52 antibody; Nucleolar protein 52 antibody; Ribosomal oxygenase MINA antibody; ROX antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human MINA
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
  • 基因功能參考文獻：
    1. RIOX2 transcripts were overexpressed in renal cell tumor subtypes compared to renal normal tissues. Higher RIOX2 transcript levels were associated with metastasis. PMID: 29099276
    2. our findings revealed that Mina53 was an important indicator of prognosis in patients with stage III colorectal cancer treated with adjuvant chemotherapy. PMID: 29750310
    3. Results indicate that mdig can inhibit the phosphorylation of GSK-3beta and promote the phosphorylation and destabilization of beta-catenin, in order to suppress the expression of slug, snail, and ZEB1 and the occurrence of EMT, and thereby inhibit the invasion and metastasis of non-small cell lung cancer (NSCLC). PMID: 29039479
    4. mdig directly interacts with c-myc and JAK1 in multiple myeloma (MM) cell lines, which contributes to hyperactivation of the IL-6-JAK-STAT3 signaling important for the pathogenesis of MM. PMID: 27833099
    5. MDIG overexpression substantially promoted hepatocellular carcinoma cell proliferation, cell migration and spreading, whereas knockdown of MDIG would reverse above-mentioned effect. PMID: 28471446
    6. Findings reveal the role of MINA in glioblastoma initiation and progression by controlling the cell-cycle progression through transcriptionally regulating cyclin and CDK expression via the demethylation of H3K9me3. PMID: 27292258
    7. Data suggest that mineral dust-induced gene protein (mdig) accomplishes its functions on chromatin, DNA repair and cell growth through interacting with the partner proteins. PMID: 26293673
    8. in lung cancer tissues, upregulation of mdig expression accompanies with the downregulation of p27(KIP1) expression and in bronchial stump PMID: 25851349
    9. Mina53 can be used as a marker for pancreatic cancer PMID: 24522517
    10. Mina: a Th2 response regulator meets TGFbeta. PMID: 25282476
    11. Increased expression of mdig in cancer tissues. PMID: 24505346
    12. mina53 expression was gradually elevated during gastric carcinogenesis, and the overexpression of mina53 was correlated with different clinicopathological features between diffuse-type gastric carcinoma and intestinal-type gastric carcinoma cases. PMID: 24337011
    13. Results imply that mdig is involved in the regulation of H3K9me3 to influence the heterochromatin structure of the genome and the expression of genes important for cell growth or transformation. PMID: 23965803
    14. results show mdig induction by arsenic is partially dependent on the JNK and STAT3 signaling pathways. PMID: 24434654
    15. these data suggest that an increased expression of mdig is an important prognostic factor for poorer survival time of the breast cancer patients. PMID: 24309373
    16. The single nucleotide polymorphism of the Mina gene is associated with the development of asthma in Chinese Han children. PMID: 21631300
    17. favorable prognostic marker in early stage lung cancer PMID: 19914733
    18. Mina53 plays an important role in carcinogenesis and may be a target for cancer prevention. PMID: 19756735
    19. role in cell division PMID: 12091391
    20. the elevated expression of Mina53 is a characteristic feature in colon cancer PMID: 14695334
    21. Mina53 may have a role in progression of esophageal squamous cell carcinoma PMID: 15534111
    22. Data suggests NO52 protein (MYC induced nuclear antigen) is directly involved in ribosome biogenesis, most likely during the assembly process of preribosomal particles. PMID: 15819408
    23. The expression of mineral dust induced mRNA was detected in alveolar macrophages from coal miners but not from normal subjects. PMID: 15897898
    24. Increased expression of Mina53 is associated with lymphoma PMID: 17786344
    25. Mina53 is overexpressed in renal cell carcinoma tissue from patients with poor prognostic factors, suggesting that Mina53 overexpression is one of the factors for poor prognosis in renal cell carcinoma. PMID: 17803656
    26. Mina53 was overexpressed in gastric carcinoma and associated with tumor proliferation and antioncogene inactivation. PMID: 18629780
    27. The MINA protein alters histone H3 methylation contributes to the initiation or development of the human lung cancer. PMID: 19502796

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Nucleus, nucleolus.
  • 蛋白家族：
    ROX family, MINA53 subfamily
  • 組織特異性：
    Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19441

    OMIM: 612049

    KEGG: hsa:84864

    STRING: 9606.ENSP00000328251

    UniGene: Hs.570562



主站蜘蛛池模板： 射精区-区区三区| 亚洲香蕉视频天天爽| 欧美熟妇与小伙性欧美交| 国产精品美女乱子伦高潮 | 无码av免费网站| 亚洲五月综合缴情在线| 精品无码日韩一区二区三区不卡 | 四虎国产精品永久在线无码| 久久久国产精品黄毛片| 少妇久久久久久被弄到高潮| 免费刺激性视频大片区| 成人国产一区二区三区精品不卡| 少妇人妻在线视频| 男女猛烈无遮挡免费视频| 国内精品九九久久久精品| 日本真人边吃奶边做爽免费视频| 夜夜高潮天天爽欧美| 精品久久亚洲中文无码| 色欲天天婬色婬香综合网完整| 女上男下啪啪激烈高潮无遮盖| 乱中年女人伦av三区| 国产成人精品男人的天堂| 最新国产aⅴ精品无码| 男人猛躁进女人免费播放| 无遮挡裸体免费视频尤物| 日韩av无码久久一区二区| 精品久久久无码中文字幕一丶| 国产大片黄在线观看私人影院| 女人与拘性猛交视频| 成人h动漫无码网站久久| 国产精品系列无码专区| 亚洲欧美日韩在线不卡| 中国女人大白屁股ass| 亚洲桃色天堂网| 国产午夜手机精彩视频| 国产激情综合五月久久| 国产成+人+综合+亚洲 欧美| 精品人无码一区二区三区| 精品欧美乱码久久久久久1区2区 | 麻批好紧日起要舒服死了| 亚洲成在人线在线播放无码vr|