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  4. MIF4GD Antibody, Biotin conjugated

MIF4GD Antibody, Biotin conjugated

  • 中文名稱：
    MIF4GD兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA013827LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MIF4GD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MIF4GD
  • 別名：
    MIF4GD antibody; SLIP1 antibody; MIF4G domain-containing protein antibody; SLBP-interacting protein 1 antibody; hSLIP1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human MIF4G domain-containing protein (1-133AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.
  • 基因功能參考文獻：
    1. Results suggest that MIF4GD is a potential regulator of p27-dependent cell proliferation in HCC. PMID: 24336329
    2. Data suggest that oligomerization and SLBP phosphorylation regulate SLBP-SLIP1-histone-mRNA complex formation/disassociation; sequential and ordered assembly is required. PMID: 23286197
    3. This paper describes the oligomeric state of SLIP1 and the SLIP1-SLBP complex and how it is regulated by SLBP phosphorylation. Using alanine scanning mutagenesis, the authors demonstrate that the binding site on SLIP1 for SLBP lies close to the dimer interface. A single-point mutant near the SLIP1 homodimer interface abolished interaction with SLBP in vitro and reduced the abundance of histone mRNA in vivo. PMID: 23286197
    4. INT6 and MIF4GD were observed to colocalize in cytoplasmic foci. It was concluded that INT6, by establishing interactions with MIF4GD and SLBP, plays an important role in translation of poly(A) minus histone mRNAs. PMID: 22532700
    5. downregulation of endogenous SLIP1 reduces the rate of translation of endogenous histone mRNA and also reduces cell viability. PMID: 18025107

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    MIF4GD family
  • 數據庫鏈接：

    HGNC: 24030

    OMIM: 612072

    KEGG: hsa:57409

    UniGene: Hs.325631



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