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  4. MICU2 Antibody, FITC conjugated

MICU2 Antibody, FITC conjugated

  • 中文名稱：
    MICU2兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA818265LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MICU2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MICU2
  • 別名：
    1110008L20Rik antibody; EF hand domain containing family member A1 antibody; EF hand domain family A1 antibody; EF hand domain family member A1 antibody; EF-hand domain-containing family member A1 antibody; EFHA1 antibody; EFHA1 EF hand domain family member A1 antibody; EFHA1_HUMAN antibody; FLJ25016 antibody; FLJ34588 antibody; Smhs2 homolog antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Calcium uptake protein 2, mitochondrial protein (26-247AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering.
  • 基因功能參考文獻：
    1. MICU2 restricts spatial crosstalk between InsP3R and MCU channels by regulating threshold and gain of MICU1-mediated inhibition and activation of MCU. PMID: 29241542
    2. MICU2 expression in the heart tissues from patients with ventricular hypertrophy. PMID: 29073106
    3. study concludes that cooperative, high-affinity interaction of the MICU1-MICU2 complex with Ca(2+) serves as an on-off switch, leading to a tightly controlled channel, capable of responding directly to cytosolic Ca(2+) signals PMID: 28615291
    4. This is the first demonstration of MICU2 deficiency in humans, which we suggest causes a distinct neurodevelopmental phenotype secondary to impaired mitochondrial calcium uniporter-mediated regulation of intracellular calcium homeostasis. PMID: 29053821
    5. Expression of MICU2 mutants lacking functional Ca2+-binding sites leads to a striking loss of Ca2+ uptake in HEK293 cells. PMID: 24503055
    6. MICU1 and MICU2 have roles in tuning the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity PMID: 24560927
    7. The results identify MICU2 as a new component of the uniporter complex that may contribute to the tissue-specific regulation of this channel. PMID: 23409044
    8. regulation of MCU-mediated mitochondrial calcium handling PMID: 23409044
    9. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624
    10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614

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  • 亞細胞定位：
    Mitochondrion intermembrane space.
  • 蛋白家族：
    MICU1 family, MICU2 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 31830

    OMIM: 610632

    KEGG: hsa:221154

    STRING: 9606.ENSP00000371811

    UniGene: Hs.412103



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