在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MGRN1 Antibody

MGRN1 Antibody

  • 中文名稱：
    MGRN1兔多克隆抗體
  • 貨號：
    CSB-PA013790GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    E3 ubiquitin-protein ligase MGRN1 antibody; KIAA0544 antibody; Mahogunin ring finger 1 antibody; Mahogunin RING finger protein 1 antibody; MGRN 1 antibody; Mgrn1 antibody; MGRN1_HUMAN antibody; Probable E3 ubiquitin protein ligase MGRN1 antibody; RING finger protein 156 antibody; RNF 156 antibody; RNF156 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human MGRN1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling.
  • 基因功能參考文獻(xiàn)：
    1. epletion of MGRN1 activity may hamper physiologically important processes like mitochondrial movement in neuronal processes and intracellular transport of ligands through the endosomal pathway thereby contributing to the pathogenesis of neurodegeneration in certain types of prion diseases PMID: 28902452
    2. In a heterologous expression system, MC1R-dependent Arrestins B ubiquitination was enhanced by overexpression of MGRN1 and was impaired by siRNA-mediated MGRN1 knockdown thus pointing to MGRN1 as the responsible E3-ligase. PMID: 28947386
    3. Hypomethylation of CpG sites in RPTOR, MGRN1 and RAPSN in blood is associated with breast cancer. PMID: 27577081
    4. Regulation of Mfn1 by MGRN1 and the proteasome modulates mitochondrial fusion. PMID: 27713096
    5. With aging, the neuroprotective e3 ligase MGRN1 relocates from the cytosol to the nucleus of neurons, where it associates with chromatin and potentiates the cellular response to proteotoxic stress. This nuclear shift is due to a proteasome impairment dependent increase of a monoubiquitinated form of MGRN1. PMID: 28475871
    6. Catalytic inactivation of MGRN1 results in elevated levels of GP78 and a consequential increase in the initiation of mitophagy. PMID: 26743086
    7. Mahogunin-mediated alpha-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation. PMID: 24556679
    8. data suggest that MGRN1 selectively targets misfolded proteins for degradation and may exhibit viable therapeutic potential for the treatment of spongiform neurodegeneration PMID: 23756845
    9. It therefore seems probable that the role of MGRN1 in the adrenal relates to the trafficking and/or degradation of the melanocortin 2 receptor. PMID: 21862608
    10. a role for Mahogunin in a proteasome-independent ubiquitylation pathway: TSG101 is a specific Mahogunin substrate PMID: 17229889
    11. Study shows that both (Ctm)PrP and cyPrP can interact with and disrupt the function of Mahogunin (Mgrn), a cytosolic ubiquitin ligase whose loss causes spongiform neurodegeneration. PMID: 19524515

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Early endosome. Note=The endosomal localization is dependent on the interaction with TSG101.; [Isoform 1]: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.; [Isoform 2]: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.; [Isoform 3]: Cytoplasm, cytosol. Cell membrane.; [Isoform 4]: Cytoplasm, cytosol. Cell membrane.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20254

    OMIM: 607559

    KEGG: hsa:23295

    STRING: 9606.ENSP00000262370

    UniGene: Hs.526494



主站蜘蛛池模板： 午夜无码国产理论在线| 曰韩精品无码一区二区视频| 中国熟妇内谢69xxxxx| 欧美日韩不卡合集视频| 国产成人欧美综合在线影院| 国产区精品系列在线观看| 另类亚洲小说图片综合区| 日本一区二区三区免费播放| 动漫av纯肉无码av在线播放| 97久久国产亚洲精品超碰热| 偷看农村妇女牲交| 国产成人精品久久一区二区| 人妻无码中字在线a| 久久超乳爆乳中文字幕| 韩国三级在线观看久| 久久精品网站免费观看| 国产精品久久久久久不卡盗摄| 鲁鲁鲁爽爽爽在线视频观看| 精品成人免费一区二区不卡| 午夜人妻理论片天堂影院| 亚洲一区二区三区含羞草| 欧美激情一区二区| 在线精品视频一区二区| 国产成人av在线影院无毒| 青青草大香焦在线综合视频| 亚洲欧洲无码一区二区三区| 日本亚洲欧美日韩国产ay| 亚洲一卡二卡三卡四卡无卡麻豆| 久久婷婷五月综合色99啪| 国产xxxx69真实实拍| 中文字幕一区二区三区久久网站 | 国产精品喷浆| av香港经典三级级 在线| 亚洲伊人丝袜精品久久| 久热爱精品视频线路一| 欧美成人片一区二区三区| 色综合久久久久无码专区| 丰满无码人妻熟妇无码区| 丰满人妻精品国产99aⅴ| 国产精品国产三级国产普通话| 久久男人av资源网站|