在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MGEA5 Antibody

  • 中文名稱:
    MGEA5兔多克隆抗體
  • 貨號:
    CSB-PA797342
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA797342(MGEA5 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA797342(MGEA5 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue, Primary antibody: CSB-PA797342(MGEA5 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    MGEA5
  • 別名:
    Beta-hexosaminidase antibody; Beta-N-acetylglucosaminidase antibody; Beta-N-acetylhexosaminidase antibody; Bifunctional protein NCOAT antibody; HEXC antibody; Hyaluronidase in meningioma antibody; KIAA0679 antibody; MEA5 antibody; Meningioma expressed antigen 5 antibody; Meningioma-expressed antigen 5 antibody; MGEA 5 antibody; Mgea5 antibody; N-acetyl-beta-D-glucosaminidase antibody; N-acetyl-beta-glucosaminidase antibody; NCOAT antibody; Nuclear cytoplasmic O GlcNAcase and acetyltransferase antibody; Nuclear cytoplasmic O-GlcNAcase and acetyltransferase antibody; OGA antibody; OGA_HUMAN antibody; Protein O-GlcNAcase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human MGEA5
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity.; Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.
  • 基因功能參考文獻:
    1. Beta-N-acetylhexosaminidase substrate recognition and specificity PMID: 28939839
    2. Tax interacts with the host OGT/OGA complex and inhibits the activity of OGT-bound OGA. PMID: 28742148
    3. TGFBR3 and/or MGEA5 rearrangements are much more common in hybrid hemosiderotic fibrolipomatous tumor-myxoinflammatory fibroblastic sarcomas than in classical myxoinflammatory fibroblastic sarcomas. PMID: 26980036
    4. Data suggest that the substrate specificity of O-GlcNAcase/OGA does not extend to proteins/peptides modified with S-GlcNAc (an analog of O-GlcNAc); proteins modified with S-GlcNAc appear to be stable against O-GlcNAcase/OGA hydrolysis. PMID: 28627871
    5. hOGA forms an unusual arm-in-arm homodimer in which the catalytic domain of one monomer is covered by the stalk domain of the sister monomer to create a substrate-binding cleft. PMID: 28319083
    6. the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT) and O-GlcNAcase (OGA), interact with the (A)gamma-globin promoter at the -566 GATA repressor site PMID: 27231347
    7. E2F1 negatively regulates both Ogt and Mgea5 expression in an Rb1 protein-dependent manner. PMID: 26527687
    8. OGA overexpression in endothelial cells improves endothelial function and may have a beneficial effect on coronary vascular complications in diabetes. PMID: 26269457
    9. Amino acid composition of splice variants, post-translational modifications, and stable associations with regulatory proteins influence subcellular distribution/substrate specificity of OGA and OGT (O-linked N-acetylglucosamine transferase). [REVIEW] PMID: 25173736
    10. This work identifies the first target of miR-539 in the heart and the first miRNA that regulates OGA. PMID: 25183011
    11. Report the presence of TGFBR3 and/or MGEA5 rearrangements in pleomorphic hyalinizing angiectatic tumors and the spectrum of related neoplasms. PMID: 24705316
    12. Estrogen replacement therapy and plyometric training influence muscle OGT and OGA gene expression, which may be one of the mechanisms by which HRT and PT prevent aging-related loss of muscle mass. PMID: 24365779
    13. O-linked beta-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-beta-D-glucosaminidase silencing on cell phenotype and transcriptome. PMID: 22730328
    14. Data show that the interplay between O-GlcNAc and phosphorylation on proteins and indicate that these effects can be mediated by changes in hOGT and hOGA kinetic activity. PMID: 22311971
    15. Analysis of urinary content of MGEA5 and OGT may be useful for bladder cancer diagnostics. PMID: 22783592
    16. Decrease in MGEA5 and increase in O-GlcNAc transferease expression in higher grade tumors suggests that increased O-GlcNAc modification may be implicated in breast tumor progression and metastasis. PMID: 21567137
    17. Chromosomal translocation t(1;10) is consistent with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor. PMID: 21717526
    18. Reducing ChREBP(OG) levels via OGA overexpression decreased lipogenic protein content (ACC, FAS), prevented hepatic steatosis, and improved the lipidic profile of OGA-treated db/db mice. PMID: 21471514
    19. Direct evidence links muscle atrophy and the disruption of O-GlcNAcase activity in male bitransgenic mice. PMID: 21178104
    20. Results provide evidence that OGA may possess a substrate-recognition mechanism tinvolving interactions with O-GlcNAcylated proteins beyond the GlcNAc-binding site. PMID: 20863279
    21. N-terminal region of OGA contains the catalytic site and the C-terminal region stabilizes the protein structure and affects substrate affinity. PMID: 20673219
    22. This study analyzes the activity of the enzyme involved in the removal of these sugar residues, i.e. beta-N-acetylglucosaminidase (O-GlcNAcase) as well as the level of N-acetylglucosamine in benign and malignant thyroid lesions. PMID: 20198314
    23. Investigated this locus in Pima Indians who have the world's highest prevalence of NIDDM. Concluded that mutations in MGEA5 are unlikely to contribute to NIDDM in this population PMID: 12359146
    24. In type 2 Diabetes patients in Mexico City, the frequency of the T allele of MGEAT5 was higher (2.6%) in the cases than in controls (1.8%), but not a significant deviation from Hardy_Weinberg proportions. PMID: 17546623
    25. review of modifications, phosphorylation and a specific form of glycosylation, O-linked -N-acetylglucosaminylation by O-GlcNAc, relevant to pathological tau phosphorylation PMID: 18641620
    26. the short nuclear variant of O-GlcNAcase, which has the identical catalytic domain as the full-length enzyme, has similar trends in a pH-rate profile and Taft linear free energy analysis as the full-length enzyme PMID: 19423084
    27. characterization of O-GlcNAcase transition states using several series of substrates to generate multiple simultaneous free-energy relationships PMID: 19715310
    28. This protein is a cytosolic, neutral, O-GlcNAc specific hexosaminidase termed O-GlcNAcase. PMID: 11148210

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 3]: Nucleus.; [Isoform 1]: Cytoplasm.
  • 蛋白家族:
    Glycosyl hydrolase 84 family
  • 組織特異性:
    Ubiquitous. Shows highest expression in the brain, placenta and pancreas.
  • 數據庫鏈接:

    HGNC: 7056

    OMIM: 604039

    KEGG: hsa:10724

    STRING: 9606.ENSP00000354850

    UniGene: Hs.500842



主站蜘蛛池模板: 天天做天天摸天天爽天天爱| 亚洲另类欧美在线电影| 亚洲s久久久久一区二区| 在线观看老湿视频福利| 成年无码av片在线| 天天拍夜夜添久久精品| 猫咪免费人成网站在线观看| 无码乱人伦一区二区亚洲| 久久99精品久久久久久秒播| 中文字幕三级人妻无码视频| 熟女人妻高清一区二区三区| 欧美搡bbbbb搡bbbbb| 99久久无码私人网站| 亚洲性色av性色在线观看| 亚洲日韩精品国产一区二区三区| 国产三级精品三级| 蜜桃无码一区二区三区| 欧洲av成本人在线观看免费| 视频久re精品在线观看| 亚洲精品中文字幕乱码| 天堂中文在线资源| 久久三级中文欧大战字幕| 狠狠色噜噜狠狠狠狠五月婷| 午夜男女爽爽影院免费视频下载| 国内精品久久久久影院薰衣草| 亚洲日本中文字幕乱码在线| 人妻聚色窝窝人体www一区| 日韩精品一区二区三区免费视频| 亚洲国产精品一区二区第四页| 又爽又黄又无遮挡的激情视频 | 久久69精品久久久久久hb| 中文字幕无码家庭乱欲| 亚洲精品无码永久在线观看性色| 性欧美性另类巨大| 亚洲精品无码久久久久av麻豆| 成人免费无码大片a毛片| 中文人妻无码一区二区三区信息| 在线观看高h无码黄动漫| 欲香欲色天天综合和网| 亚洲经典三级| 国产亚洲精品福利视频在线观看 |