在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

METTL16 Antibody

  • 中文名稱(chēng):
    METTL16兔多克隆抗體
  • 貨號(hào):
    CSB-PA013719GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    METTL16
  • 別名:
    METTL16 antibody; METT10D antibody; RNA N6-adenosine-methyltransferase METTL16 antibody; Methyltransferase 10 domain-containing protein antibody; Methyltransferase-like protein 16 antibody; N6-adenosine-methyltransferase METTL16 antibody; EC 2.1.1.348 antibody; U6 small nuclear RNA antibody; adenine-(43)-N(6))-methyltransferase antibody; EC 2.1.1.346 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human METT10D
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs. Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA. Specifically binds the 3'-end of the MALAT1 long non-coding RNA.
  • 基因功能參考文獻(xiàn):
    1. Human METTL16 is a N(6)-methyladenosine methyltransferase that targets pre-mRNAs and various non-coding RNAs. PMID: 29051200
    2. METTL16 is involved in MAT2A mRNA stability control. PMID: 29262316
    3. RNA immunoprecipitation after in vivo UV cross-linking and an in situ proximity ligation assay for RNA-protein interactions confirmed an association between METTL16 and MALAT1 in cells. METTL16 is an abundant ( approximately 5 x 10(5) molecules per cell) nuclear protein in HeLa cells. PMID: 27872311
    4. METTL16 that controls MAT2A intron retention in response to intracellular SAM levels; splicing of the MAT2A retained intron is rapidly induced upon Met depletion, and this effect requires a conserved hairpin which is a METTL16 m6A substrate. PMID: 28525753
  • 亞細(xì)胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    Methyltransferase superfamily, METTL16/RlmF family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 28484

    KEGG: hsa:79066

    STRING: 9606.ENSP00000263092

    UniGene: Hs.632237



主站蜘蛛池模板: 国产精品中文久久久久久久| 美女mm131爽爽爽作爱| 亚洲欧美人成网站在线观看看| 男女高潮喷水在线观看| 欧洲熟妇色xxxx欧美老妇多毛| 人妻 日韩精品 中文字幕| 欧美 国产 日产 韩国 在线| 久久久久久久波多野结衣高潮| 男女做爰无遮挡性视频| 农村欧美丰满熟妇xxxx| 亚洲乱码中文字幕在线| 男人a天堂手机在线版| 国产亚洲日韩妖曝欧美| 国产肉体xxxx裸体784大胆| 色94色欧美sute亚洲线路二| 高清国产一区二区三区在线| 国产av久久久久精东av| 成人做爰视频www| 99热精品久久只有精品| 天天操夜夜操| 亚洲乱码av中文一区二区软件 | 日本免费一区二区三区| 成熟丰满熟妇av无码区| 拍国产乱人伦偷精品视频| 国产欧美日韩久久久久| 精产一二三产区m553| 国产永久免费观看视频| 中文精品一卡2卡3卡4卡国色| 777米奇色狠狠俺去啦| 欧美黑人又粗又大又爽免费| 最近免费中文字幕大全免费版视频| 国产人妻久久精品二区三区| 精品无码一区二区三区的天堂| 真人作爱免费视频| 精品无码日韩一区二区三区不卡| 亚洲国产精品无码专区成人| 夜夜春夜夜爽| 五十路亲子中出在线观看| 末发育女av片一区二区| 人妻丰满熟妇ⅴ无码区a片| 抽插丰满内射高潮视频|