在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MEOX2 Antibody, Biotin conjugated

MEOX2 Antibody, Biotin conjugated

  • 中文名稱：
    MEOX2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA013696LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MEOX2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MEOX2
  • 別名：
    GAX antibody; Growth arrest-specific homeobox antibody; Homeobox protein MOX 2 antibody; Homeobox protein MOX-2 antibody; meox2 antibody; MEOX2_HUMAN antibody; Mesenchyme homeobox 2 antibody; MOX2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Homeobox protein MOX-2 protein (94-193AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation. Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle. Also acts as a negative regulator of angiogenesis. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells.
  • 基因功能參考文獻：
    1. MEOX2 polymorphism is associated with nonsyndromic cleft palate. PMID: 29030958
    2. Findings suggest that miR-130a may be involved in the development of obstructive sleep apnea hypopnea syndrome-associated pulmonary hypertension by down-regulating GAX gene PMID: 28514291
    3. MEOX2 may serve a protective role, enabling increased vessel formation despite exposure to a diabetes mellitus intrauterine environment. PMID: 27966787
    4. 3D topography transiently induces concomitant upregulation of IL-1beta and MAPK ERK1/2 through nuclear factor-kappaB-dependent signaling pathway. PMID: 26041434
    5. MEOX2 participates in chemoresistance irrespective of high CNV, but it is significantly dependent upon H3K27me3 enrichment probably associated with aggressiveness and chemotherapy failure in NSCLC patients PMID: 25460568
    6. Genetic variation in MEOX2, but not TCF15, is a strong predictor of CHD. Further experimental studies should elucidate the underlying molecular mechanisms. PMID: 26428460
    7. Microarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox2/Tcf15 heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium. PMID: 25561514
    8. downregulated expression of GAX is an independent prognostic factor and is correlated with poor survival in hepatocellular carcinoma patients PMID: 22644917
    9. MEOX1 and MEOX2 activate p16(INK4a) in a DNA binding dependent manner, whereas they induce p21(CIP1/WAF1) in a DNA binding independent manner. PMID: 22206000
    10. Report of an interaction between a homeobox protein and IkappaBbeta in endothelial cells and suggest that MEOX2 modulates the activity of the RelA complex through direct interaction with its components. PMID: 20421348
    11. homeobox protein Gax is expressed in vascular endothelium and strongly inhibits endothelial cell activation in response to growth factors and tube formation in vitro PMID: 12842453
    12. The link of MEOX2 to neurovascular dysfunction in Alzheimer disease provides new mechanistic and therapeutic insights into this illness. PMID: 16116430
    13. MEOX2 binding to RNF10 protein, human, was characterized. PMID: 16335786
    14. GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences PMID: 17074759
    15. miR-130a is a regulator of the angiogenic phenotype of vascular endothelial cells largely through its ability to modulate the expression of GAX and HOXA5 PMID: 17957028
    16. MEOX2-induced senescence is dependent upon INK4a activity, and chromatin immunoprecipitation studies indicate that MEOX2 directly binds the INK4a promoter PMID: 19340300
    17. ectopic Meox2 suppressed epithelial cell proliferation in cooperation with TGF-beta1, and mediated induction of the cell cycle inhibitor gene p21. PMID: 19383287
    18. Loss of MEOX2 gene is associated with Wilms tumor. PMID: 19760604

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Nucleus speckle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7014

    OMIM: 600535

    KEGG: hsa:4223

    STRING: 9606.ENSP00000262041

    UniGene: Hs.170355



主站蜘蛛池模板： 美女视频黄是免费| 伊人婷婷六月狠狠狠去| 波多野结衣av高清一区二区三区| 97精品超碰一区二区三区| 日本边添边摸边做边爱的网站| 婷婷四房综合激情五月| 久久99国产只有精品| 日韩卡二卡三卡四卡永久入口| av在线播放日韩亚洲欧我不卡| 亚洲人成色77777| 天码av无码一区二区三区四区| 婷婷久久香蕉五月综合| 欧美熟妇性xxxx交潮喷| 亚洲一区二区三区含羞草| 欧美牲交a欧美牲交aⅴ一| 老子午夜精品无码| 欧美乱强伦xxxxx高潮| 国产午夜福利精品一区| 国产精品无码午夜免费影院| 久久久久无码国产精品不卡| 亚洲欧美日韩中文无线码| 免费无码黄动漫十八禁| av永久天堂一区| 免费人成无码大片在线观看 | 免费看无码自慰一区二区| 亚洲国产精品自在拍在线播放蜜臀 | 超薄丝袜足j好爽在线| 999久久久国产精品消防器材| 国产成人无码18禁午夜福利网址| 久久成人伊人欧洲精品 | 少妇高潮惨叫久久久久久| 真人做作爱视频| 日韩国产成人无码av毛片蜜柚| 色欲色香天天天综合vvv| 国产三级久久久精品麻豆三级| 国产在热线精品视频99公交| 人妻换着玩又刺激又爽| 一边吃奶一边做动态图| 无码人妻一区二区三区免费看| 99精品国产福利在线观看| 国产精品成人99久久久久|