在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MEF2D Antibody

MEF2D Antibody

  • 中文名稱：
    MEF2D兔多克隆抗體
  • 貨號：
    CSB-PA010174
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    DKFZp686I1536 antibody; MADS box transcription factor 2 polypeptide D antibody; Mef2d antibody; MEF2D_HUMAN antibody; Myocyte enhancer factor 2D antibody; Myocyte specific enhancer factor 2, polypeptide D antibody; Myocyte specific enhancer factor 2D antibody; Myocyte-specific enhancer factor 2D antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human MEF-2D around the non-phosphorylation site of S444.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis.
  • 基因功能參考文獻：
    1. Our study suggests that the MEF2D, PRDM16 and ASTN2 genes from GWAS are associated with migraine susceptibility, especially migraine without aura , among Chinese patients. It appears that there is no association with serotonin receptor related genes. PMID: 28058730
    2. In summary, we found that miR-1244 affected cisplatin-treated non-small cell lung cancer via MEF2D expression. PMID: 28498474
    3. MEF2d mRNA level is up-regulated in both sporadic and SOD1 + ALS patients. PMID: 26921792
    4. MEF2D might be a potential biomarker during chronic inflammation-lung cancer transition, predicting the risk of lung cancer among patients with chronic respiratory diseases. PMID: 28340574
    5. HIF-1alpha transactivates MEF2D expression by binding to the MEF2D gene promoter to induce angiogenesis in colorectal tumors. PMID: 28478181
    6. MEF2D directly regulated transcription of the epithelial-mesenchymal transition driver gene ZEB1 and facilitated histone acetylation at the ZEB1 promoter in colorectal cancer cells PMID: 27364559
    7. MEF2D-BCL9-positive patients had B-cell precursor immunophenotype and were characterized as being older in age, being resistant to chemotherapy, having very early relapse, and having leukemic blasts that mimic morphologically mature B-cell leukemia with markedly high expression of HDAC9. PMID: 27507882
    8. These results suggest that PPARgamma may exert its antiproliferative effects by negatively regulating the MEF2D in CM cells, which through upregulation of miR-122, and PPARgamma/miR-122/MEF2D signaling pathway may be a novel target for treatment of CM. PMID: 27109478
    9. MEF2D overexpression participated in the growth of lung cancers and its aberrant expression may result from the reduction of tumor suppressor miR-218. PMID: 26409449
    10. MEF2D is a direct target of miR-19. PMID: 26762410
    11. We found that in malignant glioma, there is an aberrantly high expression of MEF2D, which leads to poor prognosis of malignant glioma. The downregulation of MEF2D suppresses the proliferation of malignant glioma cell lines by inducing delay of S and G2/M phases of cell cycle and promoting apoptosis. PMID: 26234765
    12. MEF2D regulates IGF-1-induced proliferation and apoptosis in CM development, indicating IGF-1-MEF2D pathway may be a useful target for treatment. PMID: 26563368
    13. Pokemon was found to enhance the migration and invasion of hepatocellular carcinoma by increasing MEF2D expression PMID: 26797719
    14. miR-1244 and MEF2D form an autoregulatory loop contributing to the progression of lung carcinoma. PMID: 26355845
    15. MEF2D was also found to increase the transcription of Pokemon by binding myocyte enhancer factor 2 (MEF2) sites within its promoter region, that can promote Hepatocellular carcinoma invasion PMID: 26164003
    16. Cell cycle progression was also inhibited by MEF2D suppression. PMID: 25812649
    17. OA induced cell cycle arrest in lung cancer cells through miR-122/Cyclin G1/MEF2D pathway. This finding may contribute to the understanding of the molecular mechanism of OA's anti-tumor activity PMID: 25472877
    18. MEF2D suppression was shown to decrease the proliferation of osteosarcoma cells. PMID: 25814384
    19. Oxidation of survival factor MEF2D inhibits its function, underlies oxidative stress-induced neurotoxicity, and may be a part of the Parkinson disease pathogenic process. PMID: 24219011
    20. The oncogenic properties of rhabdomyosarcoma cells can be partially attributed to the loss of MEF2D expression. PMID: 24279793
    21. MEF2D-silencing abolished hepatocellular carcinoma tumorigenicity. PMID: 24390737
    22. The expression of MEF2D was higher in the higher clinical stage of nasopharyngeal carcinoma, but there was no correlation with survival rate. PMID: 22256741
    23. direct regulation of complex I by mitochondrial MEF2D underlies its neuroprotective effects, and dysregulation of this pathway may contribute to Parkinson disease PMID: 21393861
    24. data implicate MEF2D in human cancer and suggest that MEF2D/DAZAP1 and/or DAZAP1/MEF2D contribute to leukemogenesis by altering signaling pathways normally regulated by wild-type MEF2D and DAZAP1 PMID: 15744350
    25. histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications regulate MEF2 PMID: 16166628
    26. These results reveal an unexpected role for HDAC3 and suggest a novel pathway through which MEF2 activity is controlled in vivo. PMID: 17158926
    27. MEF2D levels were increased in the brains patients with Parkinson's disease PMID: 19119233

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Note=Translocated by HDAC4 to nuclear dots.
  • 蛋白家族：
    MEF2 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6997

    OMIM: 600663

    KEGG: hsa:4209

    STRING: 9606.ENSP00000271555

    UniGene: Hs.314327



主站蜘蛛池模板： 国产高清视频在线观看97| 国产亚洲精品欧洲在线观看| 超清精品丝袜国产自在线拍| 无码喷水一区二区浪潮av| 无码人妻一区二区三区免费手机| 午夜精品一区二区三区免费视频| 久久人人爽人人爽人人片| 久久九九久精品国产日韩经典| 特级欧美插插插插插bbbbb| 乌克兰性欧美精品高清| 午夜三级a三级三点在线观看| 风流少妇又紧又爽又丰满| 国产亚洲精品久久久网站好莱| 免费男人下部进女人下部视频| 色www永久免费视频首页| 最激烈的床震娇喘视频出水| 丰满大肥婆肥奶大屁股| 老鲁夜夜老鲁| 精品视频无码一区二区三区| av在线亚洲欧洲日产一区二区 | 无尺码精品产品视频| 中文字幕婷婷日韩欧美亚洲| 成 人影片 免费观看在线| 亚洲蜜芽在线精品一区| 老熟女乱子伦| 久久se精品一区精品二区| 激情久久亚洲小说| 无遮挡18禁啪啪免费观看| 男女啪啪永久免费网站| 国产特级毛片aaaaaa高潮流水| 亚洲人成人无码网www国产| 在线精品国精品国产尤物| 国产女人高潮抽搐喷水视频| 亚洲精品乱码久久久久久蜜桃 | 午夜尤物禁止18点击进入| 黄床片30分钟免费视频教程| 国产天堂亚洲国产碰碰| 人禽无码视频在线观看| 99精品热这里只有精品| 好男人在在线社区www在线影院| 亚洲v欧美v国产v在线观看|