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MED26 Antibody, HRP conjugated

  • 中文名稱:
    MED26兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA013659LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MED26 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MED26
  • 別名:
    Activator recruited cofactor 70 kDa component antibody; Activator-recruited cofactor 70 kDa component antibody; ARC 70 antibody; ARC70 antibody; Cofactor required for Sp1 transcriptional activation subunit 7 antibody; Cofactor required for Sp1 transcriptional activation, subunit 7 (70kD) antibody; Cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa antibody; CRSP 7 antibody; CRSP complex subunit 7 antibody; CRSP70 antibody; MED 26 antibody; Med26 antibody; MED26_HUMAN antibody; Mediator complex subunit 26 antibody; Mediator of RNA polymerase II transcription subunit 26 antibody; Transcriptional coactivator CRSP70 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Mediator of RNA polymerase II transcription subunit 26 protein (372-523AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
  • 基因功能參考文獻:
    1. EAF1 (239-268) and TAF7 (205-235) peptide interactions were both mapped to the same groove formed by H3 and H4 helices of MED26 N-terminal domain. PMID: 28893534
    2. the MED26-NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7) for LEC to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes PMID: 25575120
    3. MED26 can function as a molecular switch that interacts first with TFIID in the Pol II initiation complex and then exchanges TFIID for complexes containing ELL/EAF and P-TEFb to facilitate transition of Pol II into the elongation stage of transcription. PMID: 21729782
    4. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation PMID: 12050112
    5. findings identify MED19/MED26 as a probable composite REST interface in Mediator and further clarify the mechanistic basis by which Mediator facilitates REST-imposed epigenetic restrictions on neuronal gene expression PMID: 19049968

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  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Mediator complex subunit 26 family
  • 數據庫鏈接:

    HGNC: 2376

    OMIM: 605043

    KEGG: hsa:9441

    STRING: 9606.ENSP00000263390

    UniGene: Hs.715040



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