在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MED23 Antibody

MED23 Antibody

  • 中文名稱：
    MED23兔多克隆抗體
  • 貨號：
    CSB-PA891548LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA891548LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA891548LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MED23 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MED23
  • 別名：
    130 kDa transcriptional co activator antibody; 133 kDa transcriptional co activator antibody; Activator recruited cofactor 130 kDa component antibody; Activator-recruited cofactor 130 kDa component antibody; ARC 130 antibody; ARC130 antibody; Cofactor required for Sp1 transcriptional activation subunit 3 130kDa antibody; Cofactor required for Sp1 transcriptional activation subunit 3 130kDa mediator antibody; Cofactor required for Sp1 transcriptional activation subunit 3 antibody; CRSP 130 antibody; CRSP 130 kD subunit antibody; CRSP 133 antibody; CRSP 3 antibody; CRSP complex subunit 3 antibody; CRSP130 antibody; CRSP133 antibody; CRSP3 antibody; CRSP3 protein antibody; DKFZp434H0117 antibody; DRIP 130 antibody; DRIP130 antibody; hSur-2 antibody; KIAA1216 antibody; MED 23 antibody; med23 antibody; MED23_HUMAN antibody; Mediator complex subunit 23 antibody; Mediator of RNA polymerase II transcription subunit 23 antibody; MRT18 antibody; Protein sur-2 homolog antibody; SUR 2 antibody; SUR2 antibody; Transcriptional co activator CRSP 130 antibody; Transcriptional co activator CRSP130 antibody; Transcriptional coactivator CRSP130 antibody; Vitamin D3 receptor interacting protein antibody; Vitamin D3 receptor interacting protein complex 130 kDa component antibody; Vitamin D3 receptor-interacting protein complex 130 kDa component antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Mediator of RNA polymerase II transcription subunit 23 protein (1014-1368AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，MED23 Antibody (CSB-PA891548LA01HU)，的標記方式是Non-conjugated。對于MED23 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA891548LB01HU MED23 Antibody, HRP conjugated ELISA
    FITC CSB-PA891548LC01HU MED23 Antibody, FITC conjugated
    Biotin CSB-PA891548LD01HU MED23 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.
  • 基因功能參考文獻：
    1. MED23 adopts an arch-shaped conformation, with an N-terminal domain (Nter) protruding from a large core region. PMID: 30140054
    2. This is the first patient with documented refractory epilepsy caused by a novel homozygous pathogenic variant in MED23 expanding the phenotypic spectrum. Identification of the underlying genetic defect in MED23 sheds light on the possible mechanism of complete response to the ketogenic diet in this child. PMID: 27311965
    3. a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8 PMID: 27579896
    4. Higher l-arginine was associated with higher risk of Ischemic heart disease (odds ratio and of myocardial infarction, based on 2 SNPs from MED23. PMID: 27914500
    5. MED23-associated intellectual disability has been found in two brothers from a non-consanguineous family. PMID: 25845469
    6. MED23 plays an important role in hepatocarcinogenesis, and it may be a novel target for HCC therapy. PMID: 25684393
    7. Upregulation of mediator MED23 in non-small-cell lung cancer promotes the growth, migration, and metastasis of cancer cells. PMID: 25273169
    8. Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb. PMID: 23340209
    9. Data show that Med23 RNAi specifically inhibits the proliferation and tumorigenicity of lung cancer cells with hyperactive Ras activity. PMID: 22988093
    10. missense mutation (p. R617Q) in MED23 that cosegregates with nonsyndromic autosomal recessive intellectual disability; mutation impaired response of JUN and FOS to mitogens by altering interaction between enhancer-bound transcription factors and Mediator PMID: 21868677
    11. DRIP130 regulates HER2 expression by binding to ESX PMID: 12242338
    12. loss of DRIP-130 expression, as a result of the gross loss of human chromosome 6q16.3-q23, provokes increased tumor metastasis PMID: 16964286
    13. Sur2(CRSP3) is required for activation by Adenovirus E1A CR3 activation domain and is required for MAPK-mediated activation of Elk-1. PMID: 11934987

    顯示更多

    收起更多

  • 相關疾病：
    Mental retardation, autosomal recessive 18 (MRT18)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Mediator complex subunit 23 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2372

    OMIM: 605042

    KEGG: hsa:9439

    STRING: 9606.ENSP00000357047

    UniGene: Hs.29679



主站蜘蛛池模板： 免费一区二区三区成人免费视频| 99精品产国品一二三产区| 国内一区二区三区香蕉aⅴ| 久久久久人妻一区精品果冻| 国产亚洲日韩av在线播放不卡| 97久久草草超级碰碰碰| 国产xxxx99真实实拍| 男女性爽大片视频| 99久久精品国产一区二区三区| 久久久久久亚洲精品成人| 久久久774这里只有精品17| 热99re久久国超精品首页| 亚洲欧美黑人深喉猛交群| 亚洲成av人片在线观看无码| 色综合视频一区二区三区| 亚洲日韩高清在线亚洲专区| 亚洲日韩色在线影院性色| 欧美最新精品videossexohd| 亚洲人成电影网站色www两男一女| 成人影片麻豆国产影片免费观看| 亚洲中文字幕无码永久| 青青草国产精品人人爱| 久久久久国产精品人妻aⅴ果冻| 丰满人妻av无码一区二区三区| 国产又粗又硬又大爽黄老大爷视| 无码国产午夜福利片在线观看| 国产精品国产三级在线...| 天干夜天天夜天干天2004年 | 色国产精品一区在线观看| 无码专区3d动漫精品免费| 精品高朝久久久久9999| 又色又爽又黄还免费毛片96下载| 特级西西人体444www高清大胆 | 国产美女爽到喷出水来视频| 国产台湾无码av片在线观看| 免费看欧美成人a片无码| 国产suv精品一区二区6| 人妻丰满熟妇av无码处处不卡| 俄罗斯老熟妇色xxxx| 亚洲精品中文字幕乱码三区| 久久久久国产一区二区|