在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ME1 Antibody

  • 中文名稱:
    ME1兔多克隆抗體
  • 貨號(hào):
    CSB-PA013632GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Cytosolic malic enzyme 1 antibody; HUMNDME antibody; Malate dehydrogenase antibody; Malic enzyme 1 antibody; Malic enzyme 1; NADP(+) dependent; cytosolic antibody; Malic enzyme 1; soluble antibody; Malic enzyme; cytoplasmic antibody; MAOX_HUMAN antibody; ME1 antibody; MES antibody; NADP dependent malic enzyme antibody; NADP ME antibody; NADP-dependent malic enzyme antibody; NADP-ME antibody; Pyruvic malic carboxylase antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ME1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn):
    1. Bioinformatics analysis identified that miR612 targeted ME1, which expression was high and inversely associated with miR612 expression in bladder cancer tissues. PMID: 29620192
    2. Findings indicate that malic enzyme 1 (ME1) is a valid target for molecular therapy in oral squamous cell carcinomas (OSCCs). PMID: 29601126
    3. these findings uncover a direct cross-talk mechanism between ME1 and PPP, may reveal an alternative model for signaling transduction via protein conformational simulation, and pave the way for better understanding how metabolic pathways are coordinated in cancer. PMID: 28848047
    4. ME1/ME2 expression phenotype may have a potential to be a valuable marker for sebaceous differentiation in sebaceous lesions. PMID: 26381116
    5. ME1 expression was found to be mutant-KRAS-associated in NSCLC cancer cell lines. Patients with elevated ME1 had worse outcomes after radiotherapy. Transamination generating cytosolic NADPH via ME1 may contribute to radioresistance. PMID: 26173780
    6. ME1 overexpression associates with unfavorable prognoses in patients with HCC, suggesting that ME1 is a poor prognostic predictor of hepatocellular carcinoma. PMID: 25753478
    7. essential role for ME1 in the production of cytosolic NADPH and maintenance of migratory and invasive abilities of nasopharyngeal carcinoma cells PMID: 23114090
    8. the differential protein stability between dimer and tetramer interface interactions of human c-NADP-ME PMID: 23284632
    9. p53 represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 in human and mouse cells PMID: 23334421
    10. cytosolic malic enzyme 1 gene polymorphism is associated with the degree of suppression of parathyroid hormone after long-term calcium supplementation; the effect is probably mediated through an increase in intestinal calcium absorption PMID: 22456781
    11. ME1 is a functional target gene of the BACH1 transcription factor according to ChIP-seq and knockdown analysis in HEK 293 cells. PMID: 21555518
    12. that the single mutation of Gln362 to Lys in human m-NAD-ME changes it to an NADP+-dependent enzyme, which is characteristic because it is non-allosteric, non-cooperative, and NADP+-specific PMID: 16757477
    13. although ME1 overexpression augments anaplerosis and glucose stimulated insulin secretion in INS-1 832/13 cells, it is not likely involved in methyl succinate and glucose stimulated insulin secretion in pancreatic islets PMID: 19293334
    14. human c-NADP-ME exists mainly as a tetramer, whereas human m-NAD(P)-ME exists as a mixture of dimers and tetramers PMID: 19416979
    15. A series of R98/D102 mutants examined the possible interactions between Arg98 and Asp102 using double-mutant cycle analysis. Kinetic analysis revealed that the catalytic efficiency of was severely affected by mutating both Arg98 and Asp102 residues. PMID: 19464998

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm.
  • 蛋白家族:
    Malic enzymes family
  • 組織特異性:
    Expressed in all tissues tested including liver, placenta and white adipose tissue.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6983

    OMIM: 154250

    KEGG: hsa:4199

    STRING: 9606.ENSP00000358719

    UniGene: Hs.21160



主站蜘蛛池模板: 精品人妻一区二区三区四区| 人人妻人人澡人人爽精品日本| 精品国偷自产在线| 中文幕无线码中文字蜜桃| 久久亚洲精品无码爱剪辑| 极品少妇被弄得高潮不断| 浴室人妻的情欲hd三级国产| 欧美亚洲色综久久精品国产| 丁香五月亚洲综合深深爱| 久久久久国色av∨免费看| 与子敌伦刺激对白播放| 美女国产毛片a区内射| 亚洲色大成网站在线| 久久久久国产精品人妻电影| 67194熟妇在线观看线路1| 131美女爱做视频| 亚洲综合色婷婷六月丁香宅男大增| 纯肉无遮挡h肉动漫在线观看国产| 国产精品一区二区av不卡| 妺妺窝人体色www在线小说| 黑人巨大无码中文字幕无码| av人摸人人人澡人人超碰手机版| 国产二级一片内射视频插放| 超碰色偷偷男人的天堂| 国产av毛片亚洲含羞草社| 精品久久久久久中文字幕大豆网 | 亚洲人成无码网www电影榴莲| 国内少妇偷人精品视频| 久久偷看各类wc女厕嘘嘘偷窃 | 蜜桃av蜜臀av色欲av麻| av天堂午夜精品一区| 中文人妻无码一区二区三区信息| 精品欧美аv高清免费视频| 性开放的欧美大片| 一区二区三区视频| 人人爽人人爽人人片av东京热| 欲色欲色天天天www| 热re99久久精品国99热| 国产精品老熟女露脸视频| 四虎永久地址www成人久久| 日本50岁丰满熟妇xxxx|