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MCUB Antibody, HRP conjugated

  • 中文名稱：
    MCUB兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA873671LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MCUB Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MCUB
  • 別名：
    MCUB; CCDC109B; Calcium uniporter regulatory subunit MCUb, mitochondrial; MCUb; Coiled-coil domain-containing protein 109B
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Calcium uniporter regulatory subunit MCUb, mitochondrial protein (89-219AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
  • 基因功能參考文獻(xiàn)：
    1. This study elucidated a role for CCDC109B as an oncogene and a prognostic marker in human gliomas. PMID: 28754121
    2. MCUb (also known as CCDC109b) is a paralogue of MCU (CCDC109a). MCUb physically resides within the mitochondrial uniporter complex (uniplex), which consists of the MCU, MCUb, EMRE, MICU1, and MICU2. PMID: 24231807
  • 亞細(xì)胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MCU (TC 1.A.77) family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 26076

    KEGG: hsa:55013

    STRING: 9606.ENSP00000378145

    UniGene: Hs.234149



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