在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MCM3 Antibody

  • 中文名稱:
    MCM3兔多克隆抗體
  • 貨號:
    CSB-PA005147
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of K562 cells using MCM3 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Cervical cancer proto oncogene 5 antibody; DNA polymerase alpha holoenzyme associated P1 antibody; DNA polymerase alpha holoenzyme associated protein P1 antibody; DNA polymerase alpha holoenzyme-associated protein P1 antibody; DNA replication factor MCM3 antibody; DNA replication licensing factor mcm3 antibody; HCC 5 antibody; HCC5 antibody; hRlf beta subunit antibody; Human cervical cancer proto oncogene 5 antibody; MCM 3 antibody; mcm3 antibody; MCM3 minichromosome maintenance deficient 3 antibody; MCM3_HUMAN antibody; MGC1157 antibody; Minichromosome maintenance complex component 3 antibody; Minichromosome maintenance deficient 3 antibody; Minichromosome maintenance protein 3 antibody; P1 h antibody; P1 MCM3 antibody; P1 Protein antibody; P1-MCM3 antibody; P1.h antibody; p102 antibody; P102 protein antibody; Replication licensing factor beta subunit antibody; RLF beta subunit antibody; RLF subunit beta antibody; RLFB antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human MCM3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
  • 基因功能參考文獻:
    1. this study shows that MCM3 is a novel proliferation marker in oral squamous cell carcinoma PMID: 27258565
    2. High MCM3 expression is associated with bone metastasis and advanced human prostate cancer. PMID: 28424404
    3. reveal the Minichromosome Maintenance Complex to be a critical and directly regulated node within the miR-183 signaling network in MYCN-amplified neuroblastoma cells. Randomly selected MCMs 3 and 5 were experimentally confirmed as direct targets of miR-183. PMID: 27239679
    4. The results of our preliminary study emphasize the need for future research on MCM-3 as a sensitive proliferation marker, providing an alternative to Ki-67, in cases of various major salivary gland epithelial tumors in children and adolescents. PMID: 28547962
    5. These data establish new functions for KEAP1 within the nucleus and identify MCM3 as a novel substrate of the KEAP1-CUL3-RBX1 E3 ligase. PMID: 27621311
    6. The aim of this study is to analyze the immunoexpression of Ki67, p53, MCM3 and PCNA markers in epithelial remnants of dental follicles of impacted teeth and to identify a possible correlation between the immunoexpression of these markers in dentigerous cysts and keratocystic odontogenic tumors. PMID: 27516012
    7. High MCM-3 expression correlated with Cutaneous T-cell Lymphomas. PMID: 26504025
    8. normal DNA replication and replication checkpoint activation is regulated through the novel phosphorylation of MCM3 by Chk1 PMID: 25809478
    9. The relatively lower MCM3 protein expression in FVPTC. PMID: 23821456
    10. Expression of KB cell MCM3 was not affected by doxorubicin. PMID: 24344040
    11. present study aimed to investigate the relationship between expression of minichromosome maintenance proteins (MCM-3, MCM-7), metallothioneins (MT-I/II, MT-III), and Ki-67 in 103 ovarian cancer cases, mostly of the serous histological type PMID: 24324072
    12. High MCM3 expression is associated with mucoepidermoid carcinomas and adenoid cystic carcinomas in salivary gland tumors. PMID: 23886132
    13. Relatively lower MCM3 protein expression in follicular variant of papillary thyroid carcinoma comparing to classical type could be due to a different tumorigenic pathway favored in this type of tissue. PMID: 23821456
    14. These findings provide validation of the utility of MCM3 expression as an independent biomarker for prognostication of patients with primary melanoma PMID: 22805320
    15. excess of MCM3 up-regulates the phosphorylation of CHK1 Ser-345 and CDK2 Thr-14. PMID: 21965652
    16. MCM3 gene expression is decreased in follicular variant of papillary thyroid carcinoma, contrary to expectation. PMID: 21509594
    17. Using U373MG cells we found that HCMV IE86 protein was bound to Mcm3, but did not inhibit the cellular DNA synthesis. PMID: 20545442
    18. MCM3 may be a more reliable proliferation marker than Ki-67 in accessing the growth of tumor and evaluating tumor aggressiveness of papillary thyroid carcinoma. PMID: 19818763
    19. The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with this protein PMID: 12226073
    20. Elevated MCM3 protein expression is associated with neoplasms PMID: 15623617
    21. MCM3 is overexpressed in human astrocytic tumors and elicits a cancer-restricted humoral immune response in some patients with brain neoplasms PMID: 15671553
    22. ORC1 and Mcm3 proteins are required for DNA replication in protein extracts from human cells PMID: 16537544
    23. analysis of carboxyl-terminal MCM3 phosphorylation sites and their motifs PMID: 17244605
    24. These data reveal that CDK-dependent MCM3 phosphorylation contributes to the regulated formation of the MCM2-7 complex. PMID: 18524952

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome.
  • 蛋白家族:
    MCM family
  • 數據庫鏈接:

    HGNC: 6945

    OMIM: 602693

    KEGG: hsa:4172

    STRING: 9606.ENSP00000229854

    UniGene: Hs.179565



主站蜘蛛池模板: 激情亚洲一区国产精品| 国产高清无密码一区二区三区| 国产真人做爰毛片视频直播| 精品人妻一区二区三区四区在线| 蜜臀av色欲a片无人一区| 天天综合色天天综合色h| 青青视频免费观看免费| 人人超人人超碰超国产97超碰| 中文字幕欧美人妻精品一区| 在线播放十八禁视频无遮挡| 成人无遮挡18禁免费视频| 中文字幕精品一二三四五六七八| 少妇人妻邻居| 无遮挡呻吟娇喘视频免费播放| av片亚洲国产男人的天堂| 欧美变态口味重另类在线视频| 内射无码专区久久亚洲| 成人啪啪高潮不断观看 | 超清精品丝袜国产自在线拍| 亚洲蜜桃v妇女| 一线二线三线天堂| 日本xxxx色视频在线观看| 伊人色综合九久久天天蜜桃| 国产suv精品一区二区33| 97一区二区国产好的精华液| a狠狠久久蜜臀婷色中文网| 色欲综合久久躁天天躁| 亚欧洲乱码视频一二三区| 亚洲精品无码av黄瓜影视| 亚洲乱亚洲乱妇无码麻豆 | 日韩欧美亚洲综合久久影院d3| 高清国产av一区二区三区| а天堂中文在线官网| 一本久久综合亚洲鲁鲁五月天| 中字幕久久久人妻熟女天美传媒 | 国产精品va在线观看h| 巨人精品福利官方导航| 男人扒开女人内裤强吻桶进去| 国产精品嫩草影院免费观看 | 国产成人精品日本亚洲第一区 | 成人国产精品一区二区免费看|