在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MCM10 Antibody

  • 中文名稱:
    MCM10兔多克隆抗體
  • 貨號:
    CSB-PA013589GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    MCM10
  • 別名:
    CNA43 antibody; DNA43 antibody; FLJ31133 antibody; Homolog of yeast MCM10 antibody; HsMCM10 antibody; mcm10 antibody; MCM10 minichromosome maintenance deficient 10 antibody; MCM10_HUMAN antibody; Minichromosome maintenance 10 replication initiation factor antibody; Minichromosome maintenance complex component 10 antibody; Minichromosome maintenance protein 10 isoform 1 antibody; PRO2249 antibody; Protein MCM10 homolog antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human MCM10
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38.
  • 基因功能參考文獻:
    1. Results show that MCM10 is significantly upregulated in urothelial carcinoma (UC), and associated with tumor aggressiveness. Its knockdown significantly suppressed cell proliferation in UC cell lines. PMID: 27780919
    2. Data suggest that interaction of Mcm10 with Mcm2-7 multimer requires Mcm10 domain that contains amino acids 530-655, which overlaps with domain required for stable retention of Mcm10 on chromatin; Mcm10 conserved domain (amino acids 200-482) is essential for DNA replication; both conserved domain and Mcm2-7-binding domain are required for full activity of Mcm10. PMID: 28646110
    3. RecQL4-dependent association of Mcm10 and Ctf4 with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells. PMID: 25602958
    4. MCM10 is the natural substrate of the Cul4-DDB1[VprBP] E3 ubiquitin ligase whose degradation is regulated by VprBP, but Vpr enhances the proteasomal degradation of MCM10 by interacting with VprBP. PMID: 26032416
    5. Loss of Mcm10 engages checkpoint, DNA repair and SUMO-dependent rescue pathways that collectively counteract replication stress and chromosome breakage. [Review] PMID: 24662891
    6. Mcm10 utilizes a modular architecture to act as a replisome scaffold, which helps to define possible roles in origin DNA melting, Pol alpha recruitment and coordination of enzymatic activities during elongation. PMID: 22918587
    7. Data suggest that CDC45 and MCM10 (minichromosome maintenance complex component 10) directly interact and establish a mutual co-operation in DNA binding; key domains appear to interact and then interact with DNA inside cells or in cell-free systems. PMID: 23750504
    8. This report shows that human Mcm10 is an acetylated protein regulated by SIRT1, which binds and deacetylates Mcm10 both in vivo and in vitro, and modulates Mcm10 stability and ability to bind DNA. PMID: 23449222
    9. High doses of ionizing gamma radiation and exposure to a combination of DNA-damaging chemicals do not decrease Mcm10 protein levels, demonstrating that Mcm10 down-regulation is triggered only by UV-specific damage PMID: 20064936
    10. human Mcm10 is temporarily recruited to the replication sites 30-60 min before they replicate and dissociates from chromatin after the activation of the prereplication complex PMID: 15136575
    11. transcription of human MCM10 and TopBP1 is activated by transcription factors E2F1-3, but not by factors E2F4-7 PMID: 15195143
    12. These results argue that cells can tolerate low levels of p180 as long as Mcm10 is present to "recycle" it. PMID: 17699597
    13. Mcm10 is required for chromatin loading of And-1. PMID: 17761813
    14. Results show that MCM10 molecule is a ring-shaped hexamer with large central and smaller lateral channels and a system of inner chambers. PMID: 17823614
    15. MCM10 is essential for the efficient elongation step of chromosome replication. PMID: 17997977
    16. These results indicate that MCM10 protein is essential for maintaining genome integrity as well as cell cycle progression. PMID: 17997981
    17. DNA and p180 binding to an Mcm10 construct that contains both the ID and CTD, provide the first mechanistic insight into how Mcm10 might use a handoff mechanism to load and stabilize pol alpha within the replication fork. PMID: 19608746
    18. MCM10 interacts directly with RECQ4 and regulates its DNA unwinding activity. PMID: 19696745
    19. Assembly of the Cdc45-Mcm2-7-GINS complex requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. PMID: 19805216
    20. Functional studies of the Drosophila homolog PMID: 12808023
    21. Functional studies of the Xenopus homolog PMID: 11864598

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli.
  • 蛋白家族:
    MCM10 family
  • 數據庫鏈接:

    HGNC: 18043

    OMIM: 609357

    KEGG: hsa:55388

    STRING: 9606.ENSP00000354945

    UniGene: Hs.198363



主站蜘蛛池模板: 亚洲精品无码久久久久av麻豆| 又爽又黄无遮拦成人网站| 亚洲人成网站在线播放2019| 国产乱人伦偷精品视频免观看| 国产亚洲精aa在线观看不卡| av无码午夜福利一区二区三区| 欧美3p两根一起进高清视频| 日本爽爽爽爽爽爽在线观看免 | 国产成人a亚洲精v品无码| 亚洲va欧美va天堂v国产综合 | 玩弄丰满奶水的女邻居| 国产日产欧产精品网站| 一进一出抽搐gif| 亚洲色婷婷六月亚洲婷婷6月| 中国农村妇女真实bbwbbwbbw | 99热精国产这里只有精品| 国产精品毛片无码| 成人精品一区二区三区中文字幕 | 久久狼人大香伊蕉国产| 色悠久久久久综合网国产| 污污内射在线观看一区二区少妇| 性无码专区无码片| 亚洲精品偷拍无码不卡av| 亚欧av无码乱码在线观看性色| 亚洲综合一区二区三区无码 | 夜夜未满十八勿进的爽爽影院| av无码中文一区二区三区四区| 亚洲精品无码伊人久久| 97精品超碰一区二区三区| 黄a无码片内射无码视频| 久久视频这里有精品33| 日韩a人毛片精品无人区乱码| 青青草原精品99久久精品66| 久久亚洲国产精品成人av秋霞| 麻豆果冻精东九一传媒mv| 国产人成无码视频在线1000| 国产成人艳妇aa视频在线| 国产午夜大地久久| 久久精品私人影院免费看| 怡红院成永久免费人视频新的| 久久婷婷五月国产色综合|