在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MCHR1 Antibody

  • 中文名稱:
    MCHR1兔多克隆抗體
  • 貨號:
    CSB-PA132314
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA132314(MCHR1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA132314(MCHR1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-6: Human fetal liver tissue, Human testis tissue, 293T cells, A172 cells, mouse brain tissue, human fetal brain tissue, Primary antibody: CSB-PA132314(MCHR1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    MCHR1; GPR24; SLC1; Melanin-concentrating hormone receptor 1; MCH receptor 1; MCH-R1; MCHR-1; G-protein coupled receptor 24; MCH-1R; MCH1R; MCHR; SLC-1; Somatostatin receptor-like protein
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human MCHR1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
  • 基因功能參考文獻:
    1. Polymorphisms in the MCHR1 gene are associated with differences in body composition and interact with physiologic and energy-related lifestyle factors. PMID: 24305679
    2. results suggest that MCHR1 may influence schizophrenia susceptibility, in particular among men and patients responding to conventional (nonclozapine) treatment PMID: 22081064
    3. SLC-1 protein human mutation demonstrated important genetic susceptibility of sporadic nonsyndromic hearing loss in China. PMID: 22154049
    4. DNA methylation at MCHR1 is allele-specific, age-dependent, body mass index-associated and affects transcription. PMID: 21637341
    5. two loss-of-function mutants were identified in markedly underweight individuals, raising the possibility that a lean phenotype may be linked to deficient MCHR1 signaling PMID: 20833795
    6. MCHR1 expression level was 1.6 times higher in vitiligo uninvolved skin (P < 0.05) and 2.23 times lower in involved skin (P < 0.05), when compared to healthy control skin. PMID: 20888736
    7. data suggest that RGS2 and RGS8 differentially associate with MCHR1 and may represent two distinct modes of signaling mechanisms in vivo PMID: 20633139
    8. Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. PMID: 11839762
    9. MCH1 and MCH2 receptors were investigated and are different from those in SVK14 cells. PMID: 12127971
    10. MCHR1 is expressed and functional in human skin PMID: 12176038
    11. MCHR1 receptor expression on most cell types can trigger, in the presence of MCH, cAMP synthesis and calcium mobilization in peripheral blood mononuclear cells (PBMCs). Moreover, MCH treatment decreases the CD3-stimulated PBMC proliferation in vitro. PMID: 12220661
    12. study demonstrates a complex interaction between melanin concentrating hormone receptor 1 and Gs protein-coupled signaling pathways PMID: 12865333
    13. multiple antibody binding sites on melanin-concentrating hormone receptor 1 in vitiligo, including regions between amino acids 1 to 138 and 139 to 298. PMID: 14632194
    14. Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail PMID: 15590649
    15. a single point mutation at position 255 (T255A), which is located at the junction of intracellular loop 3 and transmembrane domain 6, reduces the MCHR1 cell surface expression level to 20% of that observed for the wild-type receptor PMID: 15928315
    16. Association of MCHR1 alleles/haplotype detected might be related to juvenile-onset obesity, conditional on a particular genetic and/or environmental background. PMID: 15941924
    17. Our results suggest that MIZIP might play an important role in mammalian cells by associating with tubulin and thus might provide a link between MCHR1 and tubulin functions. PMID: 16039987
    18. study suggests that severe forms of obesity with early onset may be associated with single nucleotide polymorphisms in melanin-concentrating hormone receptor 1 (MCHR1) PMID: 16186414
    19. Study suggest that GPR24 variants may confer susceptibility to both bipolar affective disorder and schizophrenia. PMID: 16741940
    20. Single nucleotide polymorphisms of MCHR1 did not have effects on metabolic variables in humans. PMID: 18198296
    21. These data suggest that a functional interaction between MCHR1 and caveolin-1 in lipid rafts exists and provide a basis for further biochemical studies to understand the significance on MCH-mediated signal transduction events. PMID: 18722347
    22. analysis of epitope specificity of MCHR1 antibodies PMID: 19320743
    23. The 10-amino-acid cyclic core of the hMCH neuropeptide with the Arg attached to the N-terminus of the disulfide ring is sufficient for full activation of melanin-concentrating hormone receptor 1. PMID: 11478907

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4479

    OMIM: 601751

    KEGG: hsa:2847

    STRING: 9606.ENSP00000249016

    UniGene: Hs.248122



主站蜘蛛池模板: 草色噜噜噜av在线观看香蕉| 精品国内自产拍在线观看| 亚洲国产制服丝袜高清在线| 在线看片福利无码网址| 蜜桃网站入口在线进入| 羞羞色男人的天堂| 日本亚洲欧美日韩国产ay| 欧美专区另类专区在线视频| 少妇人妻偷人精品无码视频| 欧美人与物videos另类xxxxx | 中文字幕一区二区三区精彩视频| 久久无码av中文出轨人妻| 国产丰满乱子伦无码专区| 亚洲一卡2卡3卡4卡5卡乱码观看| 亚洲国产中文在线二区三区免| 无码国产69精品久久久久同性| 大香伊蕉在人线国产最新75 | 免费人成在线观看| 一二三四在线观看免费视频| 青青草国产免费久久久| 99亚洲精品自拍av成人| 国产偷国产偷亚洲高清日韩| 成人欧美一区二区三区黑人免费 | 亚洲制服丝袜自拍中文字幕| 熟妇无码乱子成人精品| av午夜久久蜜桃传媒软件| 亚洲色成人网站永久| 激情射精爽到偷偷c视频无码 | 国产国产精品人在线视| 国产乱人伦app精品久久| 精品自拍亚洲一区在线| 久久国国产免费999| 99在线在线视频观看| 亚洲人成色777777精品音频| 久久亚洲中文无码咪咪爱| 99精品国产一区二区三区不卡 | 熟女内射v888av| 在线观看免费视频污网站| 国产成人午夜无码电影在线观看| 午夜大片免费男女爽爽影院| 日本又色又爽又黄的a片吻戏|