在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MCF2 Antibody, Biotin conjugated

  • 中文名稱:
    MCF2兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA013579LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MCF2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MCF2
  • 別名:
    MCF2 antibody; DBLProto-oncogene DBL antibody; Proto-oncogene MCF-2) [Cleaved into: MCF2-transforming protein; DBL-transforming protein] antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Proto-oncogene DBL protein (705-925AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.
  • 基因功能參考文獻:
    1. Results support a role for Dbl oncogene in mammary epithelial cell differentiation and transformation and suggest the relevance of GEF deregulation in tumor onset and progression. PMID: 25723869
    2. Phosphoinositide 3-kinase C2beta regulates RhoA and the actin cytoskeleton through an interaction with Dbl PMID: 22984590
    3. Dbl is regulated by hamartin through association with ezrin. PMID: 21712385
    4. proto-oncogene dbl is not a major target for sporadic testicular germ cell tumors PMID: 19373475
    5. data describe 4 splicing variants of the human DBL (MCF-2) proto-oncogene that show different tissue distributions and guanine nucleotide exchange factor specificities PMID: 12445822
    6. provides fundamental data on the structure of Mcf-2, which regulates a variety of cellular signaling pathways PMID: 13679059
    7. These data suggest a mechanism whereby precise spatial guanine nucleotide exchange of Cdc42 by Dbl is dependent on functional ERM proteins and is important for directional cell migration. PMID: 17538024
    8. Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain PMID: 17606614
    9. Nm23-H1 can negatively regulate cell migration and tumor metastasis by modulating the activity of Cdc42 and possibly other Rho family members through interaction with Dbl-1 PMID: 18728402

    顯示更多

    收起更多

  • 相關疾病:
    MCF2 and DBL represent two activated versions of the same proto-oncogene.
  • 亞細胞定位:
    Cytoplasm.; [Isoform 1]: Membrane.; [Isoform 3]: Membrane. Note=Colocalizes with CDC42 to plasma membrane.
  • 蛋白家族:
    MCF2 family
  • 組織特異性:
    Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, int
  • 數據庫鏈接:

    HGNC: 6940

    OMIM: 311030

    KEGG: hsa:4168

    STRING: 9606.ENSP00000430276

    UniGene: Hs.387262



主站蜘蛛池模板: 少妇无码一区二区二三区| 国产96在线 | 亚洲| 欧美 日韩版国产在线播放| 中文字幕人妻无码一夲道| 伊人色综合一区二区三区| 成人伊人亚洲人综合网站| 国产在线视频天天综合网| 成年站免费网站看v片在线| 国产伦精品一区二区三区妓女| 丰满爆乳一区二区三区| 免费国产va在线观看| 不卡av中文字幕手机看| 亚洲国产香蕉碰碰人人| 无码av一区二区三区无码| 小雪尝禁果又粗又大的视频| 丁香五月亚洲综合深深爱| 一本一道色欲综合网| 亚洲中文字幕无码乱线| 99久久国产热无码精品免费| 99久久99久久久精品齐齐综合色圆| 国内精品乱码卡一卡2卡| 国产日产欧美最新| 國产一二三内射在线看片| 日本人妻人人人澡人人爽| 国产成人无码免费视频97| 亚洲国产制服丝袜高清在线| 国产精品视频一区二区三区不卡 | 华人在线亚洲欧美精品| 亚洲国产精品无码久久秋霞| 国产午夜精品一区二区三区| 一二三四免费观看在线视频中文版| 国产免费mv大全视频网站| 国产又色又爽又黄的视频在线观看 | 亚洲第一成年免费网站| 人成午夜大片免费视频| 性无码一区二区三区在线观看| 国产欧美精品aaaaaa片| 精品国产杨幂在线观看| 欧美性猛少妇xxxxx免费| 亚洲精品一区国产精品| 国产成人精品高清在线观看99|