在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MBD1 Antibody, FITC conjugated

  • 中文名稱:
    MBD1兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA883444LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MBD1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MBD1
  • 別名:
    CXXC 3 antibody; CXXC-type zinc finger protein 3 antibody; CXXC3 antibody; MBD 1 antibody; Mbd1 antibody; MBD1_HUMAN antibody; MECP1 COMPLEX antibody; Methyl CpG binding domain protein 1 antibody; Methyl CpG binding domain protein 1 isoform PCM1 antibody; Methyl CpG binding protein MBD1 antibody; Methyl CpG binding protein splice variant 1 antibody; Methyl CpG binding protein splice variant 2 antibody; Methyl CpG binding protein splice variant 3 antibody; Methyl CpG binding protein splice variant 4 antibody; Methyl-CpG-binding domain protein 1 antibody; Methyl-CpG-binding protein MBD1 antibody; PCM 1 antibody; PCM1 antibody; Protein containing methyl-CpG-binding domain 1 antibody; Regulator of fibroblast growth factor 2 (FGF 2) transcription antibody; RFT antibody; The regulator of fibroblast growth factor 2(FGF 2) transcription antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Methyl-CpG-binding domain protein 1 protein (106-355AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
  • 基因功能參考文獻(xiàn):
    1. MBD1 may be a tumor suppressor gene in advanced colorectal cancer (CRC)and affect the development and metastasis of CRC by regulating 8 tumor suppressor genes through binding with SP1. PMID: 28473981
    2. Our findings imply that reduced stability and enhanced dynamics of MBD1 or MBD6 is the origin of ATP7B dysfunction in Wilson disease patients with the G85V or G591D mutation. PMID: 27744583
    3. MBD1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner. PMID: 28449087
    4. the binding of MBD1 to nucleosomes demonstrates sequence preferences depending on the position of the methyl groups on the nucleosome. PMID: 28377300
    5. c-myc plays a key role in MBD1 mediated epigenetic silencing of KEAP1. PMID: 26980696
    6. Molecular dynamic simulation reveals mechanism of the recognition of dimethylated CpG sites by MBD1 protein. PMID: 25658035
    7. MBD1 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III. PMID: 25798578
    8. This study investigates the genetic association between methyl-CpG-binding domain (MBD) gene polymorphisms and schizophrenia. PMID: 24849540
    9. We demonstrated the importance of Aire's interaction with the ATF7ip-MBD1 protein complex in maintaining central tolerance PMID: 24464130
    10. an important function of MBD1 in DNA repair and mediation of chemoradioresistance of cancer cells PMID: 23588667
    11. higher MBD1 expression correlated with lymph node metastasis and poor survival in pancreatic cancer; gain- and loss-of-function studies in vitro validated MBD1 as a potent oncogene promoting pancreatic cancer cell invasion and epithelial-mesenchymal transition PMID: 23331011
    12. MBD1-containing chromatin associated factor 2, epithelial malignancy-related vimentin and exocytosis-related annexin A2 were changed upon exposure to airborne nanoparticle PM(0.056). PMID: 21491466
    13. This review tries to match MeCP2 structural domains, or their lack, and specific chromatin features needed for proper recruitment of MeCP2 to its functions as either activator or repressor. We specifically focused on MeCP2's role in Rett syndrome PMID: 21326358
    14. lack of binding to mCpG and interaction with NuRD/Mi2 components HDAC1 and MTA2 PMID: 12124384
    15. investigation of role of specific mutations in autism PMID: 12384770
    16. Results show that methyl-CpG binding domain protein 1 (MBD1) is expressed in tumor cells, but methyl-CpG binding domain protein 2 (MBD2) and methyl CpG binding protein 2 (MeCP2) are not. PMID: 12646234
    17. MCAF interacts with the transcriptional repression domain of MBD1 PMID: 12665582
    18. Suv39h1 enhanced MBD1-mediated transcriptional repression via MBD, not the C-terminal transcriptional repression domain of MBD1. MBD1 links to histone deacetylases through Suv39h1, causing methylation and deacetylation of histones for gene inactivation PMID: 12711603
    19. Additional evidence of variable expression in the Rett disorder phenotype is presented by a small mixed gender group of children with autistic disorder. PMID: 12770674
    20. role in chromatin compaction PMID: 12788925
    21. determination of link of p59 OASL with MBD1 transcriptional control in the context of an interferon-stimulated cell, and provision of basis for future studies to examine the functional role of this interaction PMID: 14728690
    22. regulates G1-S transition and apoptosis via p53/p21(Waf1) pathway PMID: 15081425
    23. Data show that the methyl-CpG binding protein MBD1 forms a stable complex with histone H3-K9 methylase SETDB1. PMID: 15327775
    24. These data suggest that MBD1.MCAF1.SETDB1 complex facilitates the formation of heterochromatic domains, emphasizing the role of MCAF/AM family proteins in epigenetic control, and describe a new family member, MCAF2. PMID: 15691849
    25. Methyl-CpG binding protein MBD1 binds to teneurin 1. PMID: 15777793
    26. PML-RARalpha functions by recruiting an HDAC3-MBD1 complex that contributes to the establishment and maintenance of the silenced chromatin state PMID: 16432238
    27. MBD1- and MCAF1-mediated heterochromatin formation involves SUMO modification PMID: 16757475
    28. Sex-specific time windows for concomitant upregulation of MBD1 are associated with prenatal remethylation of the human male and female germ line. PMID: 16998846
    29. Transcriptional silencing by MBD1 is regulated by a PIAS-mediated conjugation of SUMO1, which antagonizes the formation of a repressive complex with SETDB1. PMID: 17066076
    30. MBD1 and Polycomb group proteins have overlapping roles in epigenetic gene silencing and heterochromatin foci formation through their interactions. PMID: 17428788
    31. some insight into the functional mechanism of MBD1 in the development of pancreatic cancer PMID: 18445260
    32. Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes PMID: 18666890
    33. Results suggest that MBD1 polymorphisms might be involved in the development of lung cancer in Chinese population. PMID: 18668384

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus. Nucleus matrix. Nucleus speckle. Chromosome.
  • 組織特異性:
    Widely expressed.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6916

    OMIM: 156535

    KEGG: hsa:4152

    STRING: 9606.ENSP00000405268

    UniGene: Hs.405610



主站蜘蛛池模板: 偷自拍亚洲视频在线观看99 | 免费无码av片在线观看| 久久不见久久见www免费| 国产人在线成免费视频| 久久不见久久见免费视频观看| 国偷自产视频一区二区久| 无码h肉动漫在线观看| 国产精品538一区二区在线| 亚洲综合久久无码色噜噜赖水| 久久综合给久久狠狠97色| 欧美 日韩 国产 成人 在线观看| 使劲快高潮了国语对白在线| 色综合天天综合网中文| 香港曰本韩国三级网站| 欧美毛多水多肥妇| 色综合久久无码中文字幕| 国产精品一区二区香蕉| 成年片色大黄全免费网站久久| 亚洲精品久久久www小说| 最爽free性欧美人妖| 欧美 亚洲 国产 日韩 综aⅴ| 人人澡人人妻人人爽人人蜜桃麻豆| 国产1卡2卡三卡四卡精品| av老司机亚洲精品天堂| 处破痛哭a√18成年片免费| 动漫精品无码h在线观看| 国产午夜成人免费看片app| 国产sm调教折磨视频| 综合久久国产九一剧情麻豆| 黑人与中国少妇xxxx视频| 成熟女人牲交片免费观看视频| 好吊妞无缓冲视频观看| 亚洲a∨精品永久无码| 国产精品扒开腿做爽爽爽a片唱戏| 免费观看羞羞视频网站| 国产第一页浮力影院入口 | 国产卡二卡三卡四卡免费网址| 天堂va欧美ⅴa亚洲va在线| 性xxxx18免费观看视频| 无码精品人妻一区二区三区人妻斩| 亚洲色无码专区一区|