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  4. MAT2A Antibody, Biotin conjugated

MAT2A Antibody, Biotin conjugated

  • 中文名稱：
    MAT2A兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA013517LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MAT2A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    AdoMet synthase 2 antibody; AdoMet synthetase 2 antibody; AdoMet synthetase antibody; AMS 2 antibody; AMS2 antibody; MAT 2 antibody; MAT 2A antibody; MAT II antibody; MAT-II antibody; Mat2a antibody; MATA 2 antibody; MATA2 antibody; MATII antibody; Methionine adenosyltransferase 2 antibody; Methionine adenosyltransferase antibody; Methionine adenosyltransferase II alpha antibody; Methionine adenosyltransferase II antibody; METK2_HUMAN antibody; S adenosylmethionine synthetase gamma form antibody; S adenosylmethionine synthetase isoform type 2 antibody; S-adenosylmethionine synthase isoform type-2 antibody; SAMS 2 antibody; SAMS2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human S-adenosylmethionine synthase isoform type-2 protein (1-395AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
  • 基因功能參考文獻(xiàn)：
    1. MAT2A expression is upregulated through mRNA stabilization upon SAM depletion. PMID: 29262316
    2. Increased MAT2A expression is associated with recurrence in hepatocellular carcinoma. PMID: 29448301
    3. High MAT2A expression is associated with tamoxifen-resistant breast cancer. PMID: 26418898
    4. METTL16 that controls MAT2A intron retention in response to intracellular SAM levels; splicing of the MAT2A retained intron is rapidly induced upon Met depletion, and this effect requires a conserved hairpin which is a METTL16 m6A substrate. PMID: 28525753
    5. methionine adenosyltransferase II alpha (MAT2A), and the arginine methyltransferase, PRMT5, as vulnerable enzymes in cells with MTAP deletion. PMID: 27068473
    6. crystal structures of human MATalpha2 containing various bound ligands. PMID: 26858410
    7. acetylation decreased in hepatocellular cancer PMID: 25925782
    8. Mutagenesis of MATalpha2 and MATbeta phospho-sites destabilized them and prevented hepatic stellate cell trans-differentiation. PMID: 25294683
    9. The data presented here support the conclusion that rare genetic variants in MAT2A predispose individuals to thoracic aortic disease. PMID: 25557781
    10. Results suggest that MAT2A is downregulated in cancer tissues of renal cell carcinomas patients and has function of tumor suppressor though repressing the expression of heme oxygenase-1. PMID: 24636201
    11. Differential gene expression of BACE1 and PSEN1 in the knockdown cells, which is possibly a consequence of MAT2A deregulation and may indicate a self regulatory mechanism. PMID: 22879628
    12. hypoxia-induced MAT2A expression is HIF-1alpha dependent PMID: 21460102
    13. Insulin-like growth factor 1 (IGF1) activates methionine adenosyltransferase 2A MAT2A) transcription by both known and novel pathways in colon cancer cells. PMID: 21406062
    14. X protein of hepatitis B virus inhibits apoptosis in hepatoma cells through enhancing the methionine adenosyltransferase 2A gene expression and reducing S-adenosylmethionine production PMID: 21247894
    15. regulation of expression in hepatocarcinoma cells by L-methionine availability PMID: 12660248
    16. beta subunit associates with cirrhosis and cancer providing a proliferative advantage in hepatoma cells through its interaction with methionine adenosyltransferase II alpha2 and down-regulation of S-adenosylmethionine levels. PMID: 12671891
    17. up-regulation of MAT2A also provides a growth advantage and s-adenosylmethionine and methylthioadenosine can block mitogenic signaling in colon cancer cells PMID: 17631143
    18. Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells. PMID: 18041713
    19. This work was carried out to examine the role of MAT II activity and S-adenosylmethionine biosynthesis in the survival of leukemic T cells. PMID: 19048023

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  • 蛋白家族：
    AdoMet synthase family
  • 組織特異性：
    Detected in kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6904

    OMIM: 601468

    KEGG: hsa:4144

    STRING: 9606.ENSP00000303147

    UniGene: Hs.516157



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