在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MASTL Antibody, HRP conjugated

MASTL Antibody, HRP conjugated

  • 中文名稱：
    MASTL兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA846629LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MASTL Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MASTL
  • 別名：
    2700091H24Rik antibody; C88295 antibody; FLJ14813 antibody; GREATWALL antibody; Greatwall protein kinase antibody; GW antibody; GWL antibody; GWL_HUMAN antibody; hGWL antibody; MAST-L antibody; Mastl antibody; MGC117975 antibody; Microtubule associated serine/threonine kinase like antibody; Microtubule-associated serine/threonine-protein kinase-like antibody; RP11 85G18.2 antibody; Serine/threonine-protein kinase greatwall antibody; THC2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase greatwall protein (612-740AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.
  • 基因功能參考文獻(xiàn)：
    1. Using mathematical modelling, this paper confirms that deactivation of MASTL is essential for mitotic exit. PMID: 26872783
    2. these results established that precise control of MASTL is essential to couple DNA damage to mitosis through the rate of mitotic entry and APC/C activation. PMID: 26923777
    3. Thus, GWL is a human oncoprotein that promotes the hyperactivation of AKT via the degradation of its phosphatase, PHLPP, in human malignancies. PMID: 26613407
    4. Thus, Fcp1 coordinates Cdk1 and Gwl inactivation to derepress PP2A-B55, generating a dephosphorylation switch that drives mitosis progression. PMID: 26653855
    5. Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA network of neuroblastoma. PMID: 26616283
    6. Data show that siRNA knockdown of Forkhead box M1 (FOXM1) or microtubule-associated serine/threonine kinase-like (MASTL) induces radiosensitivity in non-small cell lung cancer (NSCLC). PMID: 25808837
    7. Mastl upregulation is involved in cancer progression and tumor recurrence after initial cancer therapy PMID: 25373736
    8. data demonstrate that GWL acts in a pathway with PP2A which is essential for prophase I exit and metaphase I microtubule assembly in mouse oocytes. PMID: 25472593
    9. Taken together our results suggest a hierarchy of phosphatases coordinating Greatwall, Ensa/ARPP19 and Cdk substrate dephosphorylation during mitotic exit. PMID: 24391510
    10. Studies indicate that mutations in three different genes within the THC2 locus have been associated with congenital thrombocytopenia, including a mutation in MASTL. PMID: 22102272
    11. results identify Gwl as a member of the AGC family of kinases that appears to be regulated by unique mechanisms and that differs from the other members of this family PMID: 21444715
    12. MASTL enhances cyclin B1-Cdk1-dependent mitotic phosphorylation events, directing mitotic entry, anaphase and cytokinesis in human cells. PMID: 20818157
    13. A novel missense mutation in the human gene FLJ14813 is associated with autosomal dominant thrombocytopenia PMID: 12890928
    14. A paper that narrows the identity of the gene for autosomal dominant thrombocytopenia (THC2) to FLJ14813. The mutation is present in all affected people across three generations while is absent in unaffected family members & 94 random blood donors. PMID: 12890928

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Defects in MASTL may play a role in the pathogenesis of thrombocytopenia, a disorder defined by reduced number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.
  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cleavage furrow.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 19042

    OMIM: 608221

    KEGG: hsa:84930

    STRING: 9606.ENSP00000365107

    UniGene: Hs.276905



主站蜘蛛池模板： 久久露脸国产精品| 快好爽射给我视频| 永久免费观看的毛片手机视频 | 中文字幕精品av一区二区五区| 波多野成人无码精品电影| 九九精品无码专区免费| 99久久久无码国产aaa精品| 中文字幕人妻熟女av| 一区二区三区四区在线 | 欧洲 | 99久久久无码国产精品6| 国产精品高潮呻吟av久久无吗| 99视频精品全部免费免费观看| 午夜色大片在线观看| 国产精品亚洲αv天堂无码| 九个美女露脸撒尿嘘嘘视频| 麻婆豆传媒一区二区三区| 亚洲а∨精品天堂在线| 五月婷婷俺也去开心| 午夜婷婷精品午夜无码a片影院| av无码av在线a∨天堂app| 真人抽搐一进一出视频| 欧美猛少妇色xxxxx猛叫| 亚洲国产成人超a在线播放| 又色又爽又黄的吃奶视频免费观看 | 国内精品久久久久影院老司机| 久久天天躁狠狠躁夜夜96流白浆 | 大地资源网第二页免费观看 | 97人洗澡从澡人人爽人人模| 国产产品亚洲产品| 成 人片 黄 色 大 片| 不卡无码av一区二区三区| a欧美爰片久久毛片a片| 宅女午夜福利免费视频| 中文字幕亚洲色妞精品天堂| 少妇被爽到高潮在线观看| 天堂中文官网在线| 最近中文字幕mv在线资源| 国产精品主播一区二区三区| 精品动漫一区二区无遮挡| 久久精品中文字幕| 狼群社区www中文视频|