在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MARK3 Antibody

  • 中文名稱:
    MARK3兔多克隆抗體
  • 貨號:
    CSB-PA052531
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HeLa cells and 293 cells, using MARK3 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using MARK3 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MARK3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from N-terminal of Human MARK3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1.
  • 基因功能參考文獻:
    1. Authors identified a regulatory switch controlled by MARK3 that couples microtubules to the actin cytoskeleton to establish epithelial cell polarity through ARHGEF2. PMID: 29089450
    2. findings indicate that brain PP-1I associates with and is regulated by the associated protein kinases C-TAK1 and PFTK1 PMID: 25028520
    3. We have shown that serum ALP levels modified the association of MARK3 with bone mineral density in osetoporosis for Chinese patients. PMID: 23894155
    4. interaction between Mitf and C-TAK1 was demonstrated. PMID: 20214879
    5. results show that LKB1 can direct the phosphorylation of the serine-threonine kinase PAR1A PMID: 12879020
    6. identify sequence motifs required for stable C-TAK1 association and substrate phosphorylation PMID: 12941695
    7. The C-TAK1/p78 constitutively associates with and phosphorylates KSR1 generating a 14-3-3 binding site. PMID: 15182702
    8. Data show that the protein kinase Cdc25 C-associated kinase 1 (C-TAK1) is a binding partner and a substrate of Pim-1, and suggest a role for Pim-1 as a positive regulator at the G(2)/M transition of the cell cycle. PMID: 15319445
    9. 14-3-3 binding to MARK3 is dependent on phosphorylation. PMID: 16968750
    10. Class IIa histone deacetylases (HDACs) are subjected to signal-independent nuclear export that relies on their constitutive phosphorylation. EMK and C-TAK1, are identified as regulators of this process. PMID: 16980613
    11. identify a molecular mechanism through which the hMARK3 UBA domain has evolved to bind the kinase domain PMID: 17726107
    12. occurrence of an unusual TG 3' splice site in intron 3 PMID: 17672918

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 6897

    OMIM: 602678

    KEGG: hsa:4140

    STRING: 9606.ENSP00000411397

    UniGene: Hs.35828



主站蜘蛛池模板: 久久精品国产最新地址| 粗大的内捧猛烈进出| 国产手机在线αⅴ片无码观看| 欧美激情肉欲高潮视频| 色翁荡息又大又硬又粗又爽| 无码一区二区三区老色鬼| 亚洲一线二线三线品牌精华液久久久| 国产1卡2卡三卡四卡精品| 久久人人爽人人人人片| 激情综合色综合久久综合| 中文字幕在线亚洲日韩6页| 久久精品国产精品亚洲蜜月| 国产成人久久婷婷精品流白浆 | 少妇私密会所按摩到高潮呻吟| 精品欧美一区二区三区久久久| 国产精品无码人妻一区二区在线| 精品人体无码一区二区三区| 人妻天天爽夜夜爽精品视频| 久久精品人人做人人综合| 浪潮av激情高潮国产精品| 日本中国内射bbxx| 亚洲国产成在人网站天堂| 日韩在线 | 中文| 久久久久99精品国产片| 又黄又爽又色视频免费| 亚洲色无码专区一区| 男女啪啪进出阳道猛进| 国产精品亚洲专区无码牛牛| av在线亚洲欧洲日产一区二区| 久久免费精品国产72精品九九| 国产精品亚洲专区无码唯爱网 | 中文字幕一精品亚洲无线一区| 久久99精品久久久久久| 婷婷五月婷婷五月| 久久久噜噜噜久久熟女色| 免费女人高潮流视频在线观看 | 人妻奶水人妻系列| 久久成人影院精品99| 免费午夜男女高清视频| 久久精品99久久香蕉国产色戒| 免费无码av片在线观看|