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MARK3 Antibody

  • 中文名稱:
    MARK3兔多克隆抗體
  • 貨號:
    CSB-PA052531
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HeLa cells and 293 cells, using MARK3 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using MARK3 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MARK3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from N-terminal of Human MARK3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1.
  • 基因功能參考文獻:
    1. Authors identified a regulatory switch controlled by MARK3 that couples microtubules to the actin cytoskeleton to establish epithelial cell polarity through ARHGEF2. PMID: 29089450
    2. findings indicate that brain PP-1I associates with and is regulated by the associated protein kinases C-TAK1 and PFTK1 PMID: 25028520
    3. We have shown that serum ALP levels modified the association of MARK3 with bone mineral density in osetoporosis for Chinese patients. PMID: 23894155
    4. interaction between Mitf and C-TAK1 was demonstrated. PMID: 20214879
    5. results show that LKB1 can direct the phosphorylation of the serine-threonine kinase PAR1A PMID: 12879020
    6. identify sequence motifs required for stable C-TAK1 association and substrate phosphorylation PMID: 12941695
    7. The C-TAK1/p78 constitutively associates with and phosphorylates KSR1 generating a 14-3-3 binding site. PMID: 15182702
    8. Data show that the protein kinase Cdc25 C-associated kinase 1 (C-TAK1) is a binding partner and a substrate of Pim-1, and suggest a role for Pim-1 as a positive regulator at the G(2)/M transition of the cell cycle. PMID: 15319445
    9. 14-3-3 binding to MARK3 is dependent on phosphorylation. PMID: 16968750
    10. Class IIa histone deacetylases (HDACs) are subjected to signal-independent nuclear export that relies on their constitutive phosphorylation. EMK and C-TAK1, are identified as regulators of this process. PMID: 16980613
    11. identify a molecular mechanism through which the hMARK3 UBA domain has evolved to bind the kinase domain PMID: 17726107
    12. occurrence of an unusual TG 3' splice site in intron 3 PMID: 17672918

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  • 亞細胞定位:
    Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 6897

    OMIM: 602678

    KEGG: hsa:4140

    STRING: 9606.ENSP00000411397

    UniGene: Hs.35828



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