在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MARCH8 Antibody

MARCH8 Antibody

  • 中文名稱：
    MARCH8兔多克隆抗體
  • 貨號：
    CSB-PA013491GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    MARCH8
  • 別名：
    MARCHF8; MARCH8; MIR; RNF178; E3 ubiquitin-protein ligase MARCHF8; Cellular modulator of immune recognition; c-MIR; Membrane-associated RING finger protein 8; Membrane-associated RING-CH protein VIII; MARCH-VIII; RING finger protein 178; RING-type E3 ubiquitin transferase MARCHF8
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human MARCH8
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
  • 基因功能參考文獻(xiàn)：
    1. Knockdown of MARCH8 inactivated the PI3K and ss-catenin stat3 signaling pathways by changing protein expression levels or the phosphorylation of related proteins and inhibited migration and invasion of MKN-45 and AGS cells. PMID: 30138931
    2. Two additional regulators of BST2 constitutive ubiquitylation and sorting to the lysosomes: the E3 ubiquitin ligases NEDD4 and MARCH8, are reported. PMID: 28320822
    3. Salmonella typhimurium SteD caused MARCH8-dependent ubiquitination and depletion of surface-localized mature MHC class II antigens. PMID: 27832589
    4. YopJ mediates Ser- and Lys-acetylation and affects auto-ubiquitination of ubiquitin ligase MARCH8 in human cells. PMID: 28103160
    5. Kaposi's sarcoma-associated herpesvirus RTA not only downregulated HLA-DRalpha at the protein level through direct binding and degradation through the proteasome pathway but also indirectly downregulated the protein level of HLA-DRalpha by enhancing the expression of MARCH8, a member of the membrane-associated RING-CH (MARCH) proteins. PMID: 27356905
    6. MARCH8 is highly expressed in terminally differentiated myeloid cells, and that it is a potent antiviral protein that targets viral envelope glycoproteins and reduces their incorporation into virions. PMID: 26523972
    7. MARCH 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor. PMID: 23606747
    8. MARCH8 protein localizes in lysosomes in HeLa cells PMID: 21752829
    9. endogenous MARCH-8 regulates the steady-state cell surface expression of TRAIL-R1. PMID: 23300075
    10. MARCH8-mediated polyubiquitination and degradation of IL1RAP is an important mechanism for negative regulation of IL-1beta-induced signaling pathways. PMID: 22904187
    11. MARCH8 expression led to direct ubiquitination of CD98 and routing of CD98 to late endosomes/lysosomes PMID: 21757542
    12. Membrane-Associated RING-CH proteins MARCH VIII and MARCH IV associate with Bap31 and target CD81 and CD44 to lysosomes PMID: 21151997
    13. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    14. c-MIR induced specific down-regulation of B7-2 surface expression through ubiquitination, rapid endocytosis, and lysosomal degradation PMID: 12582153
    15. Of the classifier's 11 informative genes, expression of MIR and WDR40 showed statistically significant increases for both Grade 1B and Grade >or=3A rejection. PMID: 18096478
    16. Observational study of gene-disease association. (HuGE Navigator) PMID: 16385451

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
  • 組織特異性：
    Broadly expressed. Present in immature dendritic cells (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23356

    OMIM: 613335

    KEGG: hsa:220972

    STRING: 9606.ENSP00000317087

    UniGene: Hs.499489



主站蜘蛛池模板： 狂野av人人澡人人添| 午夜无码国产理论在线| 亚洲午夜无码久久| 丰满人妻熟妇乱又伦精品软件| 少妇被粗大的猛烈进出图片| 台湾无码av一区二区三区| 免费的污污的网站在线观看| 最近2019免费中文第一页| 免费久久99精品国产自在现线 | 精品女同一区二区| 人妻丰满av无码久久不卡| 亚洲国产综合无码一区| 国产a线视频播放| 精品综合久久久久久97| 无限看片在线版免费视频大全| 日本三级在线观看免费| 阳茎伸入女人阳道视频| 亚洲色成人四虎在线观看| 一本大道大臿蕉视频无码| 国产日产人妻精品精品| 天堂中文在线资源| 亚洲a综合一区二区三区| 清纯小美女主播流白浆| 男女啪啪永久免费观看网站| 成人爱做日本视频免费| 色偷偷亚洲精品一区二区| 亚洲午夜福利院在线观看| 夜夜影院未满十八勿进| 波多野结衣中文字幕久久| 亚洲成av人片天堂网老年人| 精品一区二区三区在线观看| 日韩成人无码影院| 人妻在客厅被c的呻吟| 亚洲欧美v国产蜜芽tv| 少妇人妻偷人激情视频| 国产日韩精品中文字无码| 亚洲国产一区二区三区在观看| 人人爽人人澡人人人妻、百度| 亚洲精品成av人片天堂无码| 久久精品中文字幕| 国产精品综合一区二区三区|