在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MAPKAPK5 Antibody

MAPKAPK5 Antibody

  • 中文名稱：
    MAPKAPK5兔多克隆抗體
  • 貨號：
    CSB-PA070085
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    MAP kinase-activated protein kinase 5 antibody; MAPK-activated protein kinase 5 antibody; MAPK5_HUMAN antibody; MAPKAP kinase 5 antibody; MAPKAPK-5 antibody; MAPKAPK5 antibody; Mitogen activated protein kinase activated protein kinase 5 antibody; p38-regulated/activated protein kinase antibody; PRAK antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Human PRAK around the non-phosphorylation site of T182.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.
  • 基因功能參考文獻：
    1. MK5 is being discussed as a putative novel regulator of cardiac fibroblast function. (Review) PMID: 28941148
    2. PRAK might be a potential therapeutic target of Alzheimer's disease involved in receptor for advanced glycation end products-mediated cell signaling induced by Abeta PMID: 26758977
    3. Plasma MAPKAPK5 protein was found to positively associate with the 10-year change in paired associates learning assessment in asymptomatic older twins. PMID: 26080319
    4. Data highlight that DJ-1 is the downstream interacting target for PRAK, and in response to oxidative stress PRAK may exert a cytoprotective effect by facilitating DJ-1 to sequester Daxx in the nucleus, thus preventing cell death. PMID: 25383140
    5. Data indicate that the structurally most flexible regions during molecular dynamics (MD) simulations of the native mitogen-activated protein kinase-activated protein kinase MK5 model were the loop regions. PMID: 24651460
    6. Studies with specific phosphoantibodies indicate that MK5 phosphorylates Hsp40/DnaJB1 in vivo at Ser-149 or/and Ser-151 and Ser-171 in the C-terminal domain of Hsp40/DnaJB1. PMID: 24309468
    7. study shows Tip60 plays an essential role in oncogenic ras-induced senescence; revealed a cascade of posttranslational modifications involving p38, Tip60 and PRAK, 3 proteins essential for ras-induced senescence; these modifications are critical for prosenescent function of Tip60 and PRAK PMID: 23685072
    8. these results firstly demonstrate that MK5 is degraded in response to doxorubicin and negatively regulates doxorubicin-induced apoptosis, providing novel insights into the molecular mechanism of doxorubicin resistance in hepatoma cells. PMID: 23022185
    9. IGF2BP1 promotes the velocity and directionality of tumor-derived cell migration by determining the cytoplasmic fate of two novel target mRNAs: MAPK4 and PTEN PMID: 22279049
    10. Rheb inactivation by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1 PMID: 21336308
    11. Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway. PMID: 21177870
    12. This review discusses the different characteristics of regulating the activity and subcellular localization of MK5 and RSK1 by PKA and the functional implications of these interactions. PMID: 20849292
    13. results imply that MK5 is involved in Hsp27-controlled F-actin dynamics in response to activation of the cAMP-dependent protein kinase pathway. PMID: 19166925
    14. Data defined a novel MK5 interaction motif (FRIEDE) within both ERK4 and ERK3 that is essential for binding to the C-terminal region of MK5. PMID: 19473979
    15. Several binding motifs for heat shock factor are dispersed in the mouse and rat promoter, and temperature shock transiently enhanced the MAP-kinase-activated kinase 5 transcript levels. PMID: 19484198

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family
  • 組織特異性：
    Expressed ubiquitously.
  • 數據庫鏈接：

    HGNC: 6889

    OMIM: 606723

    KEGG: hsa:8550

    STRING: 9606.ENSP00000202788

    UniGene: Hs.333120



主站蜘蛛池模板： 日本中文字幕人妻不卡dvd| 大地资源网中文第五页| 荡女精品导航| 国产亚洲产品影视在线产品| 久久婷婷色综合老司机| 激情按摩系列片aaaa| 狠狠综合久久av一区二区| 国产成+人+综合+亚洲欧美丁香花| 亚洲精品久久国产精品浴池| 少妇富婆高级按摩出水高潮| 久久精品国产色蜜蜜麻豆 | 国产精品丝袜黑色高跟鞋| 又粗又大内射免费视频小说| 国产亚洲色婷婷久久99精品 | 亚洲精品久久久久中文第一幕| 国产精品高潮呻吟av久久小说| 无人区一线二线三线乱码| 妺妺窝人体色www在线观看| 女人喷液抽搐高潮视频| 波多野结衣中文字幕久久| 亚洲欧美综合成人五月天网站| 国产精品无码嫩草地址更新| 成人性能视频在线| 新版资源天堂中文| 国产未成女一区二区| 精品久久久久久久中文字幕| 国外av无码精品国产精品 | 久久精品成人免费观看97| 中文字幕资源网| 人人妻人人爽人人做夜欢视频| 2020国产精品永久在线| 欧美成人无码a区视频在线观看| 国产成人精品一区二区秒拍| 狠狠色综合网久久久久久| 99久久无色码中文字幕人妻| 真人床震高潮全部视频免费 | 国产又粗又猛又爽又黄的视频在线观看动漫 | 国产嘿嘿嘿视频在线观看| 免费天堂无码人妻成人av电影| 亚洲中文字幕无码中文字在线| 亚洲国产av玩弄放荡人妇|