在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAPK8IP3 Antibody

  • 中文名稱:
    MAPK8IP3兔多克隆抗體
  • 貨號:
    CSB-PA122039
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HeLa cells, using JIP3 antibody.
    • Immunofluorescence analysis of HeLa cells, using JIP3 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MAPK8IP3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human JIP3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development. Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation.
  • 基因功能參考文獻:
    1. JIP3 was highly expressed in hearts with hypertrophic cardiomyopathy. The findings indicated that blockage of JIP3 could alleviate cardiac hypertrophy via inactivating JNK pathway, and thus might be a promising strategy to prevent pathological cardiac hypertrophy. PMID: 29604277
    2. The crystal structure of an N-terminally truncated form of LZII of JIP3 alone shows an unexpected antiparallel arrangement. PMID: 26919523
    3. Results demonstrated the increased expression of JIP3 in the temporal neocortex of TLE patients and in the experimental model of epileptic seizures PMID: 26002316
    4. JSAP1 and JLP play critical roles in kinesin-1-dependent axonal transport PMID: 26320416
    5. The results of this study finding suggested that a model by which the self-assembly of SYD-2/Liprin-alpha proteins mediated by the coiled-coil LH1 domain is one of the key steps to the accumulation of presynaptic components at nascent synaptic junctions PMID: 22072677
    6. This study demonistrated that JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1. PMID: 21775604
    7. Expression of constitutively active PI3K stimulated translocation of Tiam1 to the membrane, increased Rac1 activity, and increased wound healing of airway epithelial cells. Increased Rac1 activity resulted in increased phosphorylation of JNK1. PMID: 20018857
    8. demonstration that JSAP1 bound ASK1 and enhanced ASK1- and H2O2-induced JNK activity PMID: 12189133
    9. Pressure application of 160 mmHg for 3 h produced cell proliferation and activated ERK and c-JUN N-terminal kinase PMID: 15532711
    10. JIP1 and JIP3, have a cross-talk that leads to the regulation of the ASK1-SEK1-JNK signal during glucose deprivation; cross-talk between JIP3 and JIP1 is mediated through SEK1-JNK2 and Akt1. PMID: 15911620
    11. JSAP1.FAK complex functions cooperatively as a scaffold for the JNK signaling pathway and regulator of cell migration on FN PMID: 16141199
    12. Upon UVB-induced stress in keratinocytes, ROCK1 was activated, bound to JIP-3, and activated the JNK pathway PMID: 19036714
    13. Cyclic mechanical strain impairs signaling of cell migration after injury via a pathway that involves FAK-JIP3-JNK. PMID: 19574423

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Golgi apparatus. Cytoplasmic vesicle. Cell projection, growth cone. Cell projection, axon. Cell projection, dendrite. Cytoplasm, perinuclear region.
  • 蛋白家族:
    JIP scaffold family
  • 數據庫鏈接:

    HGNC: 6884

    OMIM: 605431

    KEGG: hsa:23162

    STRING: 9606.ENSP00000250894

    UniGene: Hs.207763



主站蜘蛛池模板: 五 月 丁 香 综合中文| 国内揄拍国内精品人妻浪潮av| 人妻丝袜无码国产一区| 久爱无码免费视频在线| 夜夜爱夜鲁夜鲁很鲁| 久久久精品日本一区二区三区| 欧美午夜精品一区二区三区电影| 精品无码人妻一区二区三区品 | 中文字幕乱码人在线视频1区| 成人影院永久免费观看网址| 蜜臀av色欲a片无码一区二区| 麻豆高清免费国产一区| 亚洲色成人www永久网站| 亚洲 欧美 另类图片| 久久国产人妻一区二区免费| 丰满人妻在公车被猛烈进入电影| 国产精品久久久久久久久动漫| 免费人成网站在线观看不卡 | 国产精品高潮呻吟av久久男男 | 国产亚洲精品久久久网站好莱 | 欧美丰满熟妇xxxx| 久久久综合九色合综国产精品| 午夜福利不卡片在线机免费视频| 亚洲日本成本人观看| 日韩毛片在线视频x| 色综合久久久久综合99| 久青草久青草视频在线观看| 隔壁人妻偷人bd中字| 亚洲午夜免费福利视频| 免费的av网站在线观看国产精品| 爆乳喷奶水无码正在播放| 亚洲日本va中文字幕久久| 精品人妻系列无码人妻免费视频| 成人无码在线视频网站| 国产jk白丝在线观看免费| 情侣黄网站免费看| 天天做天天爱天天综合网2021| 国产成+人+综合+亚洲 欧美| 天堂无码人妻精品一区二区三区| 欧美激情综合五月色丁香| 欧美xxxx做受欧美1314|