在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAPK8IP1 Antibody

  • 中文名稱:
    MAPK8IP1兔多克隆抗體
  • 貨號:
    CSB-PA003081
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of COLO205 cells using JIP-1 Polyclonal Antibody
    • Western Blot analysis of colo205 HuvEc cells using JIP-1 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    MAPK8IP1 antibody; IB1 antibody; JIP1 antibody; PRKM8IP antibody; C-Jun-amino-terminal kinase-interacting protein 1 antibody; JIP-1 antibody; JNK-interacting protein 1 antibody; Islet-brain 1 antibody; IB-1 antibody; JNK MAP kinase scaffold protein 1 antibody; Mitogen-activated protein kinase 8-interacting protein 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human JIP-1 around the non-phosphorylation site of T103.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells.
  • 基因功能參考文獻:
    1. All binary complexes (KLC1:APP, KLC1:JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 and JIP1 may take part in APP transport in Alzheimer's disease patients. PMID: 27891669
    2. analysis of the role of JIP1 in APP transport; knockdown of JIP1 did not affect either amyloid precursor protein transport or amyloid-beta peptide production PMID: 23825109
    3. Data show that small GTPase RALA regulates formation of a JIP1 (C-Jun-amino-terminal-interacting protein 1) scaffold complex to propagate JNK signaling toward FOXO4 (forkhead box O transcription factor) in response to reactive oxygen species (ROS). PMID: 23770673
    4. In resected pancreatic cancer, carriers of a minor allele for rs3824872 (MAPK8IP1) were associated with a survival advantage compared with noncarriers with an additional 2-year survival if both minor alleles were present. PMID: 23360921
    5. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic beta cell death PMID: 23172226
    6. Data suggest that caspase 3-mediated cleavage of JIP1 scaffold proteins may represent an important mechanism for modulation of JNK signalling during apoptotic cell death. PMID: 21237154
    7. Data show that mechanical stress of urothelial cells activates in vivo JNK, as a consequence of a regulated expression of IB1/JIP-1, and that urothelial connexin 26 may be directly regulated by the AP-1 complex. PMID: 12064607
    8. role in promoting transcription of amyloid beta protein precursor PMID: 12563035
    9. results suggest that JIP-1b may function as a protein linking the kinesin-I motor protein to the cargo receptor, APP, and that the JNK signaling pathway may regulate the phosphorylation of this cargo protein through the JIP-1b scaffold PMID: 12665528
    10. Promoter variant is associated with Alzheimer's disease. PMID: 12740599
    11. JIP1 may act as an Akt1 scaffold, which regulates the enzymatic activity of Akt1 and can exert signaling effects independent of JNK activity PMID: 12783873
    12. JIP-1 protein may regulate kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing PMID: 12893827
    13. JIP-1 only facilitated (but is not required for) phosphorylation of Amyloid beta protein precursor but not of the two other family members APLP1 (amyloid precursor-like protein 1) and APLP2 PMID: 12917434
    14. stability is modulated by intracellular calcium PMID: 14507925
    15. Growth control of prostate cancer cells can be mediated through JNK/c-Jun pathway, but androgen responsiveness can be independent of this pathway; androgen independence in progressive prostate cancer may not occur through activation of this pathway. PMID: 15138488
    16. High IGF II expression was followed by high expression of JIP-1 in testicular neoplasms. PMID: 15868948
    17. IB1/JIP-1 participates to the neuronal phenotype of the human LNCaP cells and is a regulator of JNK signaling pathway PMID: 15894166
    18. JIP1 and JIP3, have a cross-talk that leads to the regulation of the ASK1-SEK1-JNK signal during glucose deprivation; cross-talk between JIP3 and JIP1 is mediated through SEK1-JNK2 and Akt1. PMID: 15911620
    19. Altogether, our data demonstrate that Akt1 participates in a negative regulatory feedback loop by interacting with the JIP1 scaffold protein. PMID: 15998799
    20. the phosphorylation of APP regulates the formation of a pAPP-JIP-1 complex that accumulates in neurites independent of nonphosphorylated APP PMID: 16301330
    21. Binding of JIP1 and FEZ1 to Kinesin-1 is sufficient to activate the motor for microtubule binding and motility. PMID: 17200414
    22. Thyroid cancers are characterized by APP upregulation, increased membrane targeting of the APP ectodomain and significantly increased mRNA levels of the APP scaffold proteins JIP1, ShcA and Fe65. PMID: 18480379
    23. The pathological Tau/JIP1 interaction requires phosphorylation of Tau, and Tau competes with the physiological binding of JIP1 to kinesin light chain. PMID: 19491104
    24. This review discusses the role of the JIP1 and the c-Jun NH(2)-terminal kinase pathway in the molecular pathogenesis of Alzheimer's and type 2 diabetes. JIP1 is a key regulator of the JNK pathway in neuronal and beta-cells. PMID: 19616077

    顯示更多

    收起更多

  • 相關疾病:
    Diabetes mellitus, non-insulin-dependent (NIDDM)
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum membrane. Mitochondrion membrane.
  • 蛋白家族:
    JIP scaffold family
  • 組織特異性:
    Highly expressed in brain. Expressed in neurons, localizing to neurite tips in differentiating cells. Also expressed in the pancreas, testis and prostate. Low levels in heart, ovary and small intestine. Decreased levels in pancreatic beta cells sensitize
  • 數據庫鏈接:

    HGNC: 6882

    OMIM: 125853

    KEGG: hsa:9479

    STRING: 9606.ENSP00000241014

    UniGene: Hs.234249



主站蜘蛛池模板: 亚洲成av人片无码迅雷下载| 人人妻人人爽人人添夜夜欢视频| 99久久99久久精品国产片| 久青草国产97香蕉在线视频| 久久精品免费国产大片| 少妇被爽到高潮动态图| awww在线天堂bd资源在线| 人妻 日韩 欧美 综合 制服| 国产人成午夜免电影费观看| 久久久久久国产精品美女| 亚洲一区二区观看播放| 久久久久久久97| 亚洲欲色欲香天天综合网 | 久热这里在线精品| 久久熟妇人妻午夜寂寞影院| 中文字幕人成无码人妻| 久久久亚洲精品一区二区三区浴池| 精品一卡2卡3卡4卡新区在线| 亚洲高清有码中文字| 久久综合狠狠色综合伊人| 人妻无码人妻有码中文字幕| 国产av午夜精品一区二区三| 免费人成又黄又爽的视频| 亚洲无人区码一码二码三码的含义| 国产精品久久国产三级国不卡顿| 人妻熟女一区二区aⅴ清水理纱| 人妻综合专区第一页| 女人爽到高潮潮喷18禁网站| 色噜噜狠狠色综合日日| 男人j桶进女人p无遮挡免费观看| 中文字幕韩国三级理论| 一本aⅴ高清一区二区三区| 永久免费观看的毛片手机视频| 日本高清www午色夜com| 免费国产黄网站在线观看| 久久无码高潮喷水| 国产亚洲色欲色一色www | 免费无码成人片| 无码区国产区在线播放| 蜜桃视频在线观看免费视频网站www| 免费的av网站手机版|