在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MAPK15 Antibody

MAPK15 Antibody

  • 中文名稱：
    MAPK15兔多克隆抗體
  • 貨號：
    CSB-PA002432
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HepG2 cells using ERK 8 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ERK-7 antibody; ERK-8 antibody; ERK7 antibody; ERK8 antibody; Extracellular regulated kinase 8 delta antibody; Extracellular signal regulated kinase 8 antibody; Extracellular signal-regulated kinase 7 antibody; Extracellular signal-regulated kinase 8 antibody; MAP kinase 15 antibody; MAPK 15 antibody; Mapk15 antibody; Mitogen activated protein kinase 15 antibody; Mitogen-activated protein kinase 15 antibody; MK15_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Human ERK 8 around the non-phosphorylation site of T175/Y177.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner. Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation. Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling. Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins. Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion. Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA. Regulates DA transporter (DAT) activity and protein expression via activation of RhoA. In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression. Also functions in a kinase activity-independent manner as a negative regulator of growth. Phosphorylates in vitro FOS and MBP. During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos. Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity.
  • 基因功能參考文獻：
    1. Our results describe a primary cilia-related role for this poorly studied member of the MAPK family in vivo, and indicate a broad requirement for MAPK15 in the formation of multiple ciliary classes across species. PMID: 29021280
    2. High MAPK15 expression is associated with male germ cell tumors. PMID: 26988910
    3. In HeLa cells, phosphorylation of HuR by ERK8 prevents it from binding to PDCD4 mRNA and allows miR-21-mediated degradation of PDCD4. PMID: 26595526
    4. depletion of endogenous MAPK15 expression inhibited BCR-ABL1-dependent cell proliferation, in vitro PMID: 26291129
    5. The present study suggests that MAPK15 overexpression may contribute to the malignant transformation of gastric mucosa by prolonging the stability of c-Jun. PMID: 26035356
    6. ERK8 appears as a constitutive brake on N-Acetylgalactosaminyltransferase relocalisation, and the loss of its expression could drive cancer aggressivity through increased cell motility. PMID: 24618899
    7. Data suggest that the model coulb be a tool for the development of specific ERK8 kinase inhibitors. PMID: 23326322
    8. ATG8-like proteins (MAP1LC3B, GABARAP and GABARAPL1) are novel interactors of MAPK15/ERK8, a MAP kinase involved in cell proliferation and transformation. PMID: 22948227
    9. a novel function for ERK8 as a bona fide ERRalpha corepressor, involved in control of its cellular localization by nuclear exclusion, and suggest a key role for this MAP kinase in the regulation of the biological activities of this nuclear receptor. PMID: 21190936
    10. Data show that ERK8 prevents HDM2-mediated PCNA destruction by inhibiting the association of PCNA with HDM2, and implicate ERK8 in the regulation of genomic stability. PMID: 20733054
    11. Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer PMID: 20395206
    12. ERK8, a new member of the mitogen-activated protein kinase family. PMID: 11875070
    13. The activity of ERK8 in transfected HEK-293 cells depends on the relative rates of ERK8 autophosphorylation and dephosphorylation by one or more members of the PPP family of protein serine/threonine phosphatases. PMID: 16336213
    14. Erk8 has a role as a novel effector of RET/PTC3 and, therefore, RET biological functions PMID: 16484222
    15. human ERK8 has a role as a negative regulator of human GRalpha, acting through Hic-5 PMID: 16624805
    16. Regulation of the activity and expression of DERK8 by DNA damage are reported. PMID: 19166846

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton, cilium basal body. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasmic vesicle, autophagosome. Golgi apparatus. Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
  • 組織特異性：
    Widely expressed with a maximal expression in lung and kidney.
  • 數據庫鏈接：

    HGNC: 24667

    KEGG: hsa:225689

    STRING: 9606.ENSP00000337691

    UniGene: Hs.493169



主站蜘蛛池模板： 色综合av男人的天堂伊人| 国产综合内射日韩久| 伊人精品无码av一区二区三区| 丰满岳妇乱一区二区三区| 一女被多男玩喷潮视频| 国产欧美二区综合| 男女啪啪抽搐高潮动态图| 精品久久久久香蕉网 | 国产熟女一区二区三区四区五区| 亚洲不卡av不卡一区二区| 国产精品青青青在线观看| 成熟妇女性成熟满足视频| 国产激情久久久久久熟女老人| 亚洲中文字幕精品久久久久久动漫 | 无码人妻少妇伦在线电影| 国产精品无码av天天爽播放器 | 好紧好爽好深再快点av在线| 亚洲欧美在线观看| 免费无码成人片| 亚洲一区日韩高清中文字幕亚洲| 天天天天躁天天爱天天碰| 欧美激情视频一区二区三区免费| 欧美成人免费全部| 国产永久免费观看的黄网站| 亚洲精品成人网站在线观看| 天天躁日日躁狠狠躁av麻豆男男| 日韩乱码人妻无码系列中文字幕| 日本一区二区三区不卡免费| 亚洲线精品一区二区三区| 久久国产劲爆∧v内射| 国产成人综合在线女婷五月99播放| 日本无码一区二区三区不卡免费| 国产偷人爽久久久久久老妇app| 吃奶呻吟打开双腿做受在线视频| 国产亚洲人成网站观看| 国产精品99久久久久久宅男| 国产激情无码一区二区三区| 永久久久免费人妻精品| 国精产品一区一区三区免费视频| 日韩成av人片在线观看| 国产桃色无码视频在线观看 |