在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MAP4K3 Antibody

MAP4K3 Antibody

  • 中文名稱：
    MAP4K3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA013438GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    MAP4K3 antibody; RAB8IPL1Mitogen-activated protein kinase kinase kinase kinase 3 antibody; EC 2.7.11.1 antibody; Germinal center kinase-related protein kinase antibody; GLK antibody; MAPK/ERK kinase kinase kinase 3 antibody; MEK kinase kinase 3 antibody; MEKKK 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human MAP4K3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
  • 基因功能參考文獻(xiàn)：
    1. hepatocellular carcinoma recurrence may involve germinal center kinase-like kinase PMID: 27343552
    2. Data indicate that GLK/MAP4K3 is a prognostic biomarker for non-small cell lung cancer (NSCLC) recurrence. PMID: 27203390
    3. Authors report that miR-199a-5p and let-7c cooperatively and efficiently inhibit HCC cell migration and invasion by targeting the metastasis promoter MAP4K3 and MAP4K3-mediated drug sensitization. PMID: 28099144
    4. This report details the first structure of GLK; comparison of its activation loop sequence and P-loop structure to that of Map4k4 suggests ideas for designing inhibitors that can distinguish between these family members to achieve selective pharmacological inhibitors. PMID: 27727493
    5. ITGB3 and MAP4K3 are directly repressed by let-7c, altering the metastatic potential of lung cancer cells. PMID: 23981581
    6. MAP4K3 expression is required for leucine-induced mTORC1 activation in human primary fibroblasts. PMID: 22898570
    7. Significantly higher median frequencies of circulating GLK-expressing T-cells were observed in patients with adult-onset Still's disease (31.85%) than in healthy volunteers (8.93%, P <0.001). PMID: 22867055
    8. enhanced expression in systemic lupus erythematosus PMID: 21983831
    9. Amino acid sufficiency phosphorylates MAP4K3/Ser170, activating mTORC1, but amino acid restriction causes MAP4K3 to interact with PP2A(T61 epsilon), promoting dephosphorylation of Ser170, MAP4K3 inhibition, and, inhibition of mTORC1 signaling. PMID: 20227368
    10. MAP4K3 orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM. PMID: 19587239

    顯示更多

    收起更多

  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6865

    OMIM: 604921

    KEGG: hsa:8491

    STRING: 9606.ENSP00000263881

    UniGene: Hs.655750



主站蜘蛛池模板： 2019nv天堂香蕉在线观看| 国产成人综合久久精品推下载| 黑人巨茎大战俄罗斯美女| 日韩丝袜欧美人妻制服| av毛片无码中文字幕不卡| 亚洲精品无码久久久久秋霞 | 污污污污污污污网站污| 久久精品无码专区免费| 亚洲男人av香蕉爽爽爽爽| 无码人妻品一区二区三区精99| 久久久www成人免费看片| 成人免费播放视频777777| 日产精品久久久一区二区| 香港三日本8a三级少妇三级99| 亚洲熟妇色xxxxx亚洲| 日韩精品一区二区av在线| 亚洲色中文字幕无码av| 国产精品亚洲一区二区| 人妻无码一区二区不卡无码av| 久久精品无码免费不卡| 中字幕久久久人妻熟女天美传媒| 伊人久久大香线蕉av成人| 日本50岁丰满熟妇xxxx| 免费观看激色视频网站| 免费无码又爽又刺激一高潮| 久久久婷婷五月亚洲97色| 天天躁夜夜躁狠狠是什么心态| 综合无码一区二区三区| 久久/这里只精品热在线获取| 亚洲国产欧美在线看片一国产| 97丨九色丨国产人妻熟女| 国产成人a亚洲精v品无码 | 最新永久无码av网址亚洲| 久久精品亚洲乱码伦伦中文| 中文字幕久热精品视频在线| 久久人妻少妇嫩草av无码专区| 精品国产精品久久一区免费式| 亚洲国产精品日本无码网站| 国产午夜福利不卡在线秋霞秋霞| 香港aa三级久久三级| 黑人糟蹋人妻hd中文字幕|