在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MAP4K3 Antibody

MAP4K3 Antibody

  • 中文名稱：
    MAP4K3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA013438GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    MAP4K3 antibody; RAB8IPL1Mitogen-activated protein kinase kinase kinase kinase 3 antibody; EC 2.7.11.1 antibody; Germinal center kinase-related protein kinase antibody; GLK antibody; MAPK/ERK kinase kinase kinase 3 antibody; MEK kinase kinase 3 antibody; MEKKK 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human MAP4K3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
  • 基因功能參考文獻(xiàn)：
    1. hepatocellular carcinoma recurrence may involve germinal center kinase-like kinase PMID: 27343552
    2. Data indicate that GLK/MAP4K3 is a prognostic biomarker for non-small cell lung cancer (NSCLC) recurrence. PMID: 27203390
    3. Authors report that miR-199a-5p and let-7c cooperatively and efficiently inhibit HCC cell migration and invasion by targeting the metastasis promoter MAP4K3 and MAP4K3-mediated drug sensitization. PMID: 28099144
    4. This report details the first structure of GLK; comparison of its activation loop sequence and P-loop structure to that of Map4k4 suggests ideas for designing inhibitors that can distinguish between these family members to achieve selective pharmacological inhibitors. PMID: 27727493
    5. ITGB3 and MAP4K3 are directly repressed by let-7c, altering the metastatic potential of lung cancer cells. PMID: 23981581
    6. MAP4K3 expression is required for leucine-induced mTORC1 activation in human primary fibroblasts. PMID: 22898570
    7. Significantly higher median frequencies of circulating GLK-expressing T-cells were observed in patients with adult-onset Still's disease (31.85%) than in healthy volunteers (8.93%, P <0.001). PMID: 22867055
    8. enhanced expression in systemic lupus erythematosus PMID: 21983831
    9. Amino acid sufficiency phosphorylates MAP4K3/Ser170, activating mTORC1, but amino acid restriction causes MAP4K3 to interact with PP2A(T61 epsilon), promoting dephosphorylation of Ser170, MAP4K3 inhibition, and, inhibition of mTORC1 signaling. PMID: 20227368
    10. MAP4K3 orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM. PMID: 19587239

    顯示更多

    收起更多

  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6865

    OMIM: 604921

    KEGG: hsa:8491

    STRING: 9606.ENSP00000263881

    UniGene: Hs.655750



主站蜘蛛池模板： 久久国产精品人妻丝袜| 精品久久久久久无码免费| 久久久无码人妻精品一区| 亚洲一卡2卡3卡4卡 精品| 无码少妇一区二区三区免费| 成人亚洲a片v一区二区三区动漫| 青青草原精品99久久精品66| 少妇太爽了在线观看免费视频| 亚洲乱码一区二三四区ava| 精品一区二区三区国产在线观看| 亚洲国产品综合人成综合网站| 色欲狠狠躁天天躁无码中文字幕| 国产97色在线 | 日韩| 国产清纯白嫩初高生在线观看| 国产午夜福利精品一区| 香蕉久久人人爽人人爽人人片av| 精品亚洲成a人片在线观看少妇| 97成人碰碰久久人人超级碰oo| 欧美日韩人妻精品一区二区在线| 大伊香蕉精品视频在线直播| 小说区 图片区色 综合区| 中文字幕日本最新乱码视频 | 国产成人精品永久免费视频 | 久久精品99久久香蕉国产色戒 | 天天躁夜夜躁狠狠躁2020| 亚洲日韩国产中文其他| 中国白嫩丰满人妻videos| 亚洲一区二区三区写真| 人妻精品久久久久中文字幕| 国精品无码av人妻受辱系| 国产精品∧v在线观看| 亚洲天天做日日做天天谢日日欢| √天堂资源地址中文在线| 色欲av永久无码精品无码| 在线精品视频一区二区三四| 人妻少妇偷人精品视频| 欧美大浪妇猛交饥渴大叫| 免费h动漫无码网站| 国产又粗又硬又大爽黄老大爷| 男男啪啪激烈高潮cc漫画免费 | 国产精品 中文字幕 亚洲 欧美|