在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MAP4K1 Antibody

MAP4K1 Antibody

  • 中文名稱：
    MAP4K1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA570132
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA570132(MAP4K1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA570132(MAP4K1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Hematopoietic progenitor kinase 1 antibody; Hematopoietic progenitor kinase antibody; HPK1 antibody; Human Hematopoietic Progenitor Kinase antibody; M4K1_HUMAN antibody; Map4k1 antibody; MAPK/ERK kinase kinase kinase 1 antibody; MEK kinase kinase 1 antibody; MEKKK 1 antibody; Mitogen activated protein kinase kinase kinase kinase 1 antibody; Mitogen-activated protein kinase kinase kinase kinase 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human MAP4K1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate. Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production.
  • 基因功能參考文獻(xiàn)：
    1. Interactions between HPK1 and its adaptor proteins related to immunity has been discussed (Review). PMID: 28901492
    2. HPK1 protein expression, which is expressed at significantly higher levels in NATs compared with paired IDC-NOS tissues, is significantly negatively associated with ER positivity and is positively associated with OS duration, suggesting that HPK1 may exhibit anticancer activities. PMID: 28765906
    3. CUL7/Fbxw8 ubiquitin ligase-mediated HPK1 degradation revealed a direct link and novel role of CUL7/Fbxw8 ubiquitin ligase in the MAPK pathway, which plays a critical role in cell proliferation and differentiation. PMID: 24362026
    4. HPK1 is critically involved in LFA-1-mediated polymorphonuclear neutrophils trafficking during acute inflammation. PMID: 23460610
    5. results indicate that uncleaved HPK1 is a positive regulator of vitamin D-induced differentiation in acute myeloid leukemia cells, but the cleaved HPK1 fragment inhibits differentiation PMID: 22421156
    6. Pdcd4 knockdown up-regulates MAP kinase kinase kinase kinase 1 (MAP4K1) expression and increases phosphorylation of c-Jun. PMID: 22801218
    7. QVD and 1,25D-induced differentiation was accompanied by increased signaling by Hematopoietic Progenitor Kinase 1(HPK1), and the expression of transcription factors known to be involved in monocytic differentiation was increased. PMID: 22541691
    8. HPK1 negatively regulates T cell activation by reducing the persistence of signaling microclusters. PMID: 22105350
    9. The purpose of the study was to investigate the potential contribution of HPK1, MEKK1, TAK1, p-MKK4 to the development of extramammary Paget disease PMID: 21915030
    10. The catalytic activity of a hematopoietic cell-restricted, Ste20-related S/TPK, HPK1, is positively regulated by exposure to physiological concentrations of PGE2. HPK1 is a negative regulator of PGE2-induced FOS gene transcription. PMID: 12522005
    11. PP4 is a positive regulator for HPK1 and the HPK1-JNK signaling pathway PMID: 15364934
    12. Full activation of HPK1 is dependent on autophosphorylation of threonine 165 and phosphorylation of serine 171, which is a target site for protein kinase D (PKD) in vitro. PMID: 15743830
    13. suppression or activation of NFkappaB by HPK1 determines sensitivity to activation-induced cell death PMID: 16341093
    14. Pdcd4 suppresses tumor progression in colon carcinoma cells by the novel mechanism of down-regulating MAP4K1 transcription, with consequent inhibition of c-Jun activation and AP-1-dependent transcription. PMID: 16449643
    15. Our work explains growth factor-independent survival during monocytic differentiation by caspase-mediated processing of HPK1 towards HPK1-N. PMID: 17024227
    16. A novel negative feedback loop involves HPK-1-dependent serine phosphorylation of SLP-76 and 14-3-3 protein recruitment, which tunes T cell activation. PMID: 17353368
    17. HPK1-C as a suppressor of antiapoptotic Bcl-2 proteins and provide a molecular basis for our understanding of CD95L-independent activation-induced cell death of lymphocytes. PMID: 17712048
    18. Prostaglandin E2 activates HPK1 kinase activity via a PKA-dependent pathway PMID: 17895239
    19. Restoring wild-type HPK1 protein in pancreatic cancer cells led to the increase in p21 and p27 protein expression and cell cycle arrest. HPK1 may function as a novel tumor suppressor and its loss plays a critical role in pancreatic cancer. PMID: 19141650
    20. Results suggest HPK1-mediated phosphorylation of CARMA1 as an additional regulatory mechanism tuning the NF-kappaB response upon TCR stimulation. PMID: 19706536

    顯示更多

    收起更多

  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6863

    OMIM: 601983

    KEGG: hsa:11184

    STRING: 9606.ENSP00000380066

    UniGene: Hs.95424



主站蜘蛛池模板： 2021亚洲国产成a在线| 久久青草费线频观看| 夜夜躁狠狠躁2021| 日本午夜免费啪视频在线 | 亚洲成av人片高潮喷水 | 97久久精品人人澡人人爽| 国产成人av免费观看| 国产性―交―乱―色―情人| 色欲天天婬色婬香视频综合网| 超薄丝袜足j好爽在线| 日本中文字幕在线| 国产午夜成人av在线播放| 亚洲小说图区综合在线| 精品一区二区三区影院在线午夜| 欧洲国产精品无码专区影院| 久久久久99精品成人片三人毛片 | 免费人成视频19674不收费| 丰满多毛的大隂户视频| 天天爽天天摸天天碰| 娜娜麻豆国产电影| 国产乱人伦真实精品视频| 80s国产成年女人毛片| 国产欧美成人xxx视频| 人人妻人人澡人人爽偷拍台湾| 2020久热爱精品视频在线观看| 野狼av午夜福利在线| 日本又色又爽又黄的视频免 | 免费人成网站视频在线观看国内| 曰批视频免费30分钟成人 | 最近的中文字幕在线看视频| 亚洲一区二区三区国产精华液| 国内外精品激情刺激在线| 国产精品无码一区二区牛牛| 国产日韩一区二区三区在线观看| 国产精品天干天干有线观看| 鲁丝片一区二区三区毛片| 亚洲熟妇av一区二区三区浪潮| 免费无码av一区二区三区| 熟女体下毛毛黑森林| 国产精品久久自在自线青柠| 免费啪视频在线观看视频网页|