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MAP4 Antibody

  • 中文名稱:
    MAP4兔多克隆抗體
  • 貨號:
    CSB-PA010006
  • 規(guī)格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    MAP4
  • 別名:
    DKFZp779A1753 antibody; MAP-4 antibody; MAP4 antibody; MAP4_HUMAN antibody; MGC8617 antibody; Microtubule associated protein 4 antibody; Microtubule-associated protein 4 antibody; OTTHUMP00000210723 antibody; OTTHUMP00000210725 antibody; OTTHUMP00000210727 antibody; OTTHUMP00000210730 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human MAP-4 around the non-phosphorylation site of S696.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
  • 基因功能參考文獻:
    1. Expression level of MAP4 mRNA and protein in lung adenocarcinoma tissues were significantly higher than those in noncancerous tissues. MAP4 expression significantly correlated with tumor progression. PMID: 29743960
    2. Microtubule-associated protein 4 (MAP4) controls the dynein-dependent transport of BTN3A1 in response to nucleic acid stimulation, thereby identifying MAP4 as an upstream regulator of BTN3A1. Thus, the depletion of either MAP4 or BTN3A1 impairs cytosolic DNA- or RNA-mediated type I IFN responses. PMID: 27911820
    3. an intratumoral injection of MAP4-small interfering RNA (siRNA) remarkably inhibited the growth of the tumors that formed by the MAP4-expressing ESCC cells in nude mice, and a combination of MAP4-siRNA and Bevacizumab significantly enhanced the inhibition effect. Our data suggest that MAP4 is probably a useful prognostic biomarker and a potential therapeutic target for the disease. PMID: 26876215
    4. MAP4 acts as a checkpoint molecule that balances positive and negative hallmarks of T cell activation. PMID: 28209780
    5. Results show that marker rs218966 in gene PHF14 and rs9836027 in MAP4 significantly associated with hypertension; additionally, rare variants in SNUPN significantly associated with systolic blood pressure. PMID: 26866982
    6. We demonstrated that the MAP4 (Ser696 and Ser787) phosphorylation increased concomitantly with the p38/MAPK pathway activation by the LPS and TNF-alpha stimulation of HPMECs, which induced MT disassembly followed by hyperpermeability. PMID: 25746230
    7. Results demonstrated that MAP4 mutations contribute to the clinical spectrum of centrosomal defects and confirmed the complex role of a centrosomal protein in centrosomal, ciliary, and Golgi regulation associated with severe short stature. PMID: 25323976
    8. Data show that cAMP/alpha isoform of the catalytic subunit of human PKA (PKAc-alpha) signaling can disrupt microtubule (MT) cytoskeleton by the phosphorylation of microtubule-Associated Protein 4 (MAP4). PMID: 24140250
    9. MAP4, which is a binding partner of SEPT2. PMID: 23572511
    10. there are two possible mechanisms triggered by MAP4: stabilization of MT networks; DYNLT1 modulation, which is connected with VDAC1, and inhibition of hypoxia-induced mitochondrial permeabilization PMID: 22164227
    11. DNAL1 and MAP4 may exert their functions in the HIV life cycle at reverse transcription, prior to nuclear translocation. PMID: 22018492
    12. Data show that the tau-related protein MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis. PMID: 21822276
    13. Results suggest that structural features of the PJ domain of MAP4 may contribute to the formation of a radial array of microtubules in proliferating cells. PMID: 12079337
    14. demonstrate that ectopic MAP4 promotes outgrowth of extended MTs during beta1-integrin-induced cell spreading PMID: 12123579
    15. activity of MAP4 is downregulated by reduced free tubulin concentrations PMID: 12890753
    16. adenovirus 2 E1B-55K protein blocks p53 as a transcriptional repressor protein of the survivin and the MAP4 promoters PMID: 14527689
    17. MAP4 microtubule decoration interferes with beta-adrenergic receptor recycling and that this may be one mechanism for beta-adrenergic receptor downregulation in heart failure. PMID: 15528234
    18. Truncation of the projection domain of MAP4 leads to attenuation of microtubule dynamic instability. PMID: 15840946
    19. mAP4 interaction with septins modulates microtubule dynamics. PMID: 16093351
    20. This first report of a genetic alteration involving MAP4 points to a potentially relevant target gene in diffuse large B-cell lymphoma. PMID: 16804917

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  • 亞細胞定位:
    Cytoplasm, cytoskeleton.
  • 數據庫鏈接:

    HGNC: 6862

    OMIM: 157132

    KEGG: hsa:4134

    STRING: 9606.ENSP00000353375

    UniGene: Hs.517949



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