在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAP2K4 Antibody

  • 中文名稱:
    MAP2K4兔多克隆抗體
  • 貨號:
    CSB-PA788410
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HUVEC cells using MAP2K4 Antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MAP2K4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Peptide sequence around aa.352~356(E-S-K-R-P)derived from Human MAP2K4.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
  • 基因功能參考文獻:
    1. These results provide valuable insights into the role of acetylation in MKK4-JNK signaling in T cells. PMID: 29248490
    2. This study demonstrates that MKK4 employs a subtle combination of interaction modes in order to bind to p38 alpha, leading to a complex displaying significantly different dynamics across the bound regions. PMID: 29276882
    3. MKK4 overexpression enhanced TNF-alpha-mediated signaling activation and transcription of downstream catabolic genes, and consequently worsened cartilage degradation. PMID: 29072705
    4. Study provides evidence that phosphorylated MKK4 (pMKK4) might function as a tumor suppressor in colorectal cancer (CRC). Downregulation of pMKK4 was associated with a more aggressive phenotype and with increases in local invasion and metastasis. pMKK4 was also strongly associated with disease-free survival. PMID: 28423721
    5. Androgen-induced miR-27A acted as a tumor suppressor by targeting MAP2K4 and mediated prostate cancer progression PMID: 27594411
    6. the expression level of MAP2K4 was inversely associated with the expression of miR-802 in tongue squamous cell carcinoma (TSCC) tissues; demonstration that the MAP2K4 expression was upregulated in TSCC cell lines; elevated expression of miR-802 inhibited TSCC cell viability and invasion through inhibiting MAP2K4 expression PMID: 28319306
    7. MKK4 activates non-canonical NFkappaB signaling by promoting NFkappaB2-p100 processing. PMID: 28733031
    8. Manipulating the expression of both miR-222 and miR-25 influenced diverse gene expression changes in thyroid cells. Increased expression of miR-25 reduced MEK4 and TRAIL protein expression, and cell adhesion and apoptosis are important aspects of miR-25 functioning in thyroid cells. PMID: 27353001
    9. Association between MKK4 promoter polymorphism and breast cancer risk in Kashmiri population PMID: 27509166
    10. In Chinese Han ischemic stroke patients rs3826392 C/A genotype carriers showed significantly higher IL-1b serum levels. PMID: 26856463
    11. the presence of the -1304T > G polymorphism is likely to decrease risk of cancer (Meta-Analysis) PMID: 26554761
    12. The plasma level of protein MAP2K4 was found to suggestively associate negatively with the volume of the left entorhinal cortex in asymptomatic older twins. PMID: 26080319
    13. MAP2K4 increases human prostate cancer metastasis, and prolonged over expression induces long term changes in cell signaling pathways leading to independence from p38 MAPK and JNK. PMID: 25019290
    14. MKK4 is activated in vitro by reduced Trx but not oxidized Trx in the absence of an upstream kinase, suggesting that autophosphorylation of this protein occurs due to reduction of Cys-246 and Cys-266 by Trx. PMID: 26028649
    15. Data suggest a genetic interaction between MAP2K4 and HLA-DRB1, and the importance of rs10468473 and MAP2K4 splice variants in the development of autoantibody-positive RA. PMID: 25732927
    16. knockdown of Sec8 enhances the binding of JIP4 to MAPK kinase 4, thereby decreasing the phosphorylation of MAPK kinase 4, JNK, and p38. PMID: 25244576
    17. Demonstrate that Mkk4 is a negative regulator of the TGF-beta1 signaling associated with atrial remodeling and arrhythmogenesis with age. PMID: 24721794
    18. MicroRNA-27a promotes proliferation, migration and invasion by targeting MAP2K4 in human osteosarcoma cells. PMID: 24556602
    19. Single nucleotide polymorphisms in MAP2K4 gene is associated with gastric cancer. PMID: 23921907
    20. Arrestin-3 directly interacts with MKK7 and promotes JNK3alpha2 phosphorylation by both MKK4 and MKK7 in vitro as well as in intact cells. PMID: 23960075
    21. If both p53 and the SAPKK MKK4 are simultaneously inactivated, persistent polo-like kinase 4 activity combined with the lack of SAPK-mediated inhibition of centrosome duplication conspire to induce supernumerary centrosomes under stress. PMID: 23653187
    22. Rs12939944 located in the MAP2K4 intron was associated with decreased risk. PMID: 23299404
    23. MicroRNA-92a negatively regulates Toll-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase PMID: 23355465
    24. Crystal structures combined with small-angle X-ray scattering experiments revealed that the apo form of non-phosphorylated MAP2K4 (npMAP2K4) exists in a transient state which has a longer conformation compared with the typical kinase folding. PMID: 22828509
    25. Results suggest that the functional -1304G variant in the MKK4 promoter decreases the risk of PCa by increasing the promoter activity. PMID: 22526163
    26. the functional -1304G variant in the MKK4 promoter contributes to a decreased risk of cervical cancer PMID: 22335172
    27. Overexpression of MAP2K4 in osteosarcoma was correlated with poor treatment response, disease progression and poor overall survival. PMID: 22154052
    28. Suggest that in pancreatic ductal adenocarcinomas, the MKK4 protein was directly related to high cell proliferation. PMID: 22158075
    29. protective role of genetic variant MKK4 -1304T>G is restrained in nasopharyngeal carcinoma (NPC) with Epstein-Barr Virus (EBV) infection. These findings implicate the role of EBV and MKK4 -1304 T>G interaction as a causative factor for the NPC. PMID: 21702039
    30. MKK4 was identified as playing a key role in Tau-S422 phosphorylation in human neuroblastoma cells. PMID: 21638028
    31. The purpose of the study was to investigate the potential contribution of HPK1, MEKK1, TAK1, p-MKK4 to the development of extramammary Paget disease PMID: 21915030
    32. Building on the foundation of daring hypotheses: using the MKK4 metastasis suppressor to develop models of dormancy and metastatic colonization. PMID: 21925502
    33. 8 out of 11 cancer-associated MAP2K4 mutations reduce MKK4 protein stability or impair its kinase activity PMID: 21896780
    34. MAP2K4 is targeted by genetic inactivation in ovarian cancer and restricted to high grade serous and endometrioid carcinomas in our cohort. PMID: 21575258
    35. These results indicated that MKK4 acts as a tumor suppressor and may represent an important therapeutic target for the treatment of ovarian cancer PMID: 21487811
    36. Compared with the -1304TT genotype, patients with the -1304TG genotype had a significantly decreased risk of acute myeloid leukemia PMID: 21518142
    37. Loss of MKK4 expression is associated with endometrial cancer. PMID: 21372598
    38. These results suggest that JNK affects the association of alpha-catenin with the adherens junction complex and regulates adherens junctions. PMID: 21030692
    39. Data indicate that MKK4 gene knockdown in MDAH2774 cells over-expressing MKK4 increased invasion activity. PMID: 20309881
    40. the crystal structures of human non-phosphorylated MKK4 kinase domain (npMKK4) complexed with AMP-PNP (npMKK4/AMP) and a ternary complex of npMKK4, AMP-PNP and p38alpha peptide (npMKK4/AMP/p38) were determined. PMID: 20732303
    41. Functional -1304G variant in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity. PMID: 20554746
    42. Elevated MKK4 abundance inhibited cell proliferation and increased the phosphorylation and activity of p38 and PRAK. Thus, multiple microRNAs acting on a single target, the MKK4 mRNA, collectively influence MKK4 abundance during replicative senescence PMID: 19861690
    43. There appears to be consistent rate of genetic inactivation of MAP2K4 among most tumor types, including breast cancer. PMID: 11754110
    44. JNK-dependent phosphorylation and thus inactivation of Mcl-1 may be one of the mechanisms through which oxidative stress induces cellular damage PMID: 12223490
    45. Jun N-terminal kinase has a role in IL-4 induction PMID: 12368275
    46. in the setting of wild-type PTEN, PI3K- and MKK4/JNK-dependent pathways cooperate to maintain cell survival. PMID: 12714585
    47. regulation of fibroblast functions important for wound healing by basal JNK activity PMID: 12730213
    48. docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates PMID: 12788955
    49. JNK, MKK-4, and MKK-7 form an active signaling complex in rheumatoid arthritis and this novel JNK signalsome is activated in response to IL-1 and migrates to the nucleus PMID: 13130464
    50. JNK and p38 MAPK activities in UVA-induced signaling pathways leading to AP-1 activation and c-Fos expression PMID: 14511403

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
  • 組織特異性:
    Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
  • 數據庫鏈接:

    HGNC: 6844

    OMIM: 601335

    KEGG: hsa:6416

    STRING: 9606.ENSP00000262445

    UniGene: Hs.514681



主站蜘蛛池模板: 四虎国产成人永久精品免费| 任你躁在线精品免费| 无套内谢的新婚少妇国语播放| 黑人大战亚洲人精品一区| 日本久久综合久久综合| 丰满又黄又爽少妇毛片| 香蕉久久精品日日躁夜夜躁夏 | 国产美女视频免费观看的网站| 久久无码中文字幕免费影院| 免费无遮挡无码视频在线观看| 麻豆精品导航| 最新永久无码av网址亚洲| 亚洲欧美在线制服丝袜国产| 国产精品99久久久久久久女警| 天天射寡妇射| 久久精品日日躁夜夜躁欧美| 亚洲国产区男人本色vr| 日本无遮挡边做边爱边摸| 男女吃奶做爰猛烈紧视频| 夫前人妻被灌醉侵犯在线| 久久精品人人做人人综合| 亚洲国产精品热久久| 国产性猛交普通话对白| 国产精品久久久久9999不卡| 午夜无码人妻av大片色欲| 狠狠色综合网丁香五月| 女人爽到喷水的视频大全| 在线天堂免费观看.www| 强行糟蹋人妻hd中文| 日本精品一区二区三区四区| 亚洲aⅴ在线无码播放毛片一线天| 久久综合狠狠综合久久激情| 使劲快高潮了国语对白在线| 久久视频这里有精品33| 在线观看国产丝袜控网站| 亚洲中文字幕无码一区| 国内自产少妇自拍区免费| 蜜臀av国产精品久久久久| 亚洲精品午夜国产va久久成人 | 精品人妻无码专区中文字幕| 亚洲一码二码三码精华液|