在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAP1S Antibody

  • 中文名稱:
    MAP1S兔多克隆抗體
  • 貨號:
    CSB-PA013407GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    MAP1S
  • 別名:
    BPY2-interacting protein 1 antibody; BPY2IP1 antibody; C19orf5 antibody; FLJ10669 antibody; MAP-1S antibody; MAP1S antibody; MAP1S light chain antibody; MAP1S_HUMAN antibody; MAP8 antibody; MGC133087 antibody; microtubule-associated protein 1S antibody; Microtubule-associated protein 8 antibody; Variable charge Y chromosome 2-interacting protein 1 antibody; VCY2-interacting protein 1 antibody; VCY2IP-1 antibody; VCY2IP1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human MAP1S
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles.
  • 基因功能參考文獻:
    1. Results suggested that microtubule associated protein 1S (MAP1S) were up-regulated among Crohn's disease (CD) patients and MAP1S-related autophagy inhibits apoptosis of intestinal epithelial cells (IECs) through Wnt/beta-catenin signaling pathway which might play a vital role in the protection of intestinal mucosal barrier and inhibition the progression of CD. PMID: 28188784
    2. Autophagy defects in the degradation of lipid droplets triggered by the MAP1S deficiency may enhance the initiation and development of ccRCC and reduce the survival of ccRCC patients. PMID: 26701856
    3. HDAC4 destabilizes MAP1S, suppresses autophagy flux and promotes the accumulation of mHTT aggregates. PMID: 26540094
    4. Ddata underline the key role of MAP1S as a global regulator of microbutule stability and demonstrate a new primary function of MAP1S to regulate MT dynamics at the onset of cytokinesis. PMID: 25300793
    5. results support a role for MAP1 proteins in promoting efficient retrograde trafficking of HIV-1 by stimulating the formation of stable microtubules and mediating the association of HIV-1 cores with microtubules. PMID: 25505242
    6. The PU.1-regulated MAP1S gene is implicated in neutrophil differentiation and autophagy control. PMID: 25043887
    7. clarify roles of MAP1S in bridging microtubules and mitochondria with autophagic and mitophagic initiation, maturation, trafficking, and lysosomal clearance. PMID: 21262964
    8. The amino acid sequence of VCY2IP-1 shows 59.3% and 41.9% homology to two human microtubule-associated proteins (MAPs), MAP1B and MAP1A, respectively. VCY2IP-1 has an extensive homology to the N-terminus and C-terminus regions of MAP1B and MAP1A PMID: 14627543
    9. is expressed in a wide range of tissues in addition to neurons and represents the non-neuronal counterpart of a cytolinker family PMID: 15528209
    10. Deletion mutagenesis indicated that C19ORF5 selectively binds double stranded DNA through its microtubule binding domain. PMID: 15907802
    11. These results suggest that the interaction of SOCS3 with MAP1S and the integrity of the microtubule cytoskeleton play an important role in the negative regulation of SOCS3 on IL-6 signaling. PMID: 19027008
    12. C19ORF5 distributed broadly across the mitotic spindle and reversibly accumulated during reversible mitotic arrest. PMID: 19759419

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族:
    MAP1 family
  • 組織特異性:
    Expressed in neurons (at protein level). Expressed in spermatocytes, spermatids and spermatozoa. Expressed in the cerebral cortex. Highly expressed in testis. Moderately expressed in the brain, colon, heart, kidney, liver, lung, placenta, small intestine,
  • 數據庫鏈接:

    HGNC: 15715

    OMIM: 607573

    KEGG: hsa:55201

    STRING: 9606.ENSP00000325313

    UniGene: Hs.66048



主站蜘蛛池模板: 日韩欧美群交p内射捆绑| 久久精品国产99久久6动漫| 日本高清视频wwww色| 潮喷无码正在播放| 日韩av片无码一区二区不卡电影| 精品国产一区二区三区av 性色| 欧美多人片高潮野外做片黑人| 麻豆精品一卡二卡三卡| 久久天天躁狠狠躁夜夜夜| 涩涩鲁亚洲精品一区二区| 日本一区二区三区免费高清| 国产999精品久久久久久| 日本丰满少妇xxxx| 女人的天堂a国产在线观看 | 亚洲理论电影在线观看| 欧美国产精品日韩在线| 成人亚洲a片v一区二区三区蜜臀| 2018年秋霞无码片| 国产激情一区二区三区| 精品福利视频一区二区三区| 国产成人无码精品久久久性色| 久久综合少妇11p| 久久国产超碰女女av| 男人j进女人p免费视频| 国产精品丝袜一区二区三区| 永久免费的无码中文字幕| 狠狠色噜噜狠狠狠狠米奇777| 国内老熟妇乱子伦视频 | 日本三级欧美三级人妇视频黑白配| 高清情侣国语自产拍| 亚洲色欲在线播放一区| 日韩一区二区三区无码人妻视频| 精品一区二区三区在线成人| 伊人成年网站综合网| 亚洲国产欧美在线成人app| 中文字幕一区二区三区乱码| 爱久久av一区二区三区| 亚洲成在人线视av| 国产一区二区三区 韩国女主播 | 久久久精品国产免大香伊| 在线 | 麻豆国产传媒61国产免费 视频在线+欧美十亚洲曰本 |