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MAP1LC3C Antibody

  • 中文名稱:
    MAP1LC3C兔多克隆抗體
  • 貨號:
    CSB-PA915606
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA915606(MAP1LC3C Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA915606(MAP1LC3C Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    MAP1LC3C
  • 別名:
    ATG8J antibody; Autophagy-related protein LC3 C antibody; Autophagy-related ubiquitin-like modifier LC3 C antibody; LC3 like protein 2 antibody; MAP1 light chain 3 like protein 2 antibody; MAP1 light chain 3 like protein 3 antibody; MAP1 light chain 3-like protein 3 antibody; MAP1A/MAP1B LC3 C antibody; MAP1A/MAP1B light chain 3 C antibody; MAP1LC3C antibody; Microtubule-associated protein 1 light chain 3 gamma antibody; Microtubule-associated proteins 1A/1B light chain 3C antibody; MLP3C_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human MAP1LC3C
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins.
  • 基因功能參考文獻:
    1. a basal, housekeeping mitophagy pathway that involves piecemeal degradation of mitochondrial proteins in a LC3C- and p62-dependent manner and contributes to mitochondrial homeostasis maintenance when cells rely on oxidative phosphorylation. PMID: 29149599
    2. a non-canonical autophagy pathway reminiscent of LC3-associated phagocytosis contributes to Vpu counteraction of BST2 restriction. PMID: 27880899
    3. The WDR81 interacts with LC3C through canonical LC3-interacting regions in the BEACH domain, promoting LC3C recruitment to ubiquitinated proteins. PMID: 28404643
    4. Results indicate that TECPR2 Binds LC3and the complex is required for autophagosome formation, possibly through regulation of functional ER exit sites PMID: 26431026
    5. both autophagy-related 5 and microtubule-associated protein 1 light chain 3B levels are decreased in patients with melanomas as compared with those with benign nevi PMID: 24300435
    6. ccytoplasm against Salmonella. PMID: 23022382

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  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes.
  • 蛋白家族:
    ATG8 family
  • 組織特異性:
    Most abundant in placenta, lung and ovary.
  • 數據庫鏈接:

    HGNC: 13353

    OMIM: 609605

    KEGG: hsa:440738

    STRING: 9606.ENSP00000349785

    UniGene: Hs.534971



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