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  4. MAN2C1 Antibody, Biotin conjugated

MAN2C1 Antibody, Biotin conjugated

  • 中文名稱：
    MAN2C1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA878885LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MAN2C1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MAN2C1
  • 別名：
    MAN2C1 antibody; MANA antibody; MANA1Alpha-mannosidase 2C1 antibody; EC 3.2.1.24 antibody; Alpha mannosidase 6A8B antibody; Alpha-D-mannoside mannohydrolase antibody; Mannosidase alpha class 2C member 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Alpha-mannosidase 2C1 protein (746-969AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm.
  • 基因功能參考文獻：
    1. MAN2C1 may contribute to the verbal difficulties observed in microduplications and to the intellectual disability of microdeletion syndromes PMID: 27355585
    2. Man2C1 has dual functions: one in glycan catabolism and another in apoptotic signaling. PMID: 23486476
    3. MAN2C1 binds PTEN thereby inhibiting its phosphatidylinositol 3,4,5 triphosphate phosphatase activity PMID: 21556061
    4. MAN2C1 methylation levels modify cumulative traumatic burden on risk of post traumatic stress disorder PMID: 21508515
    5. regulation of Man2C1 expression is essential for maintaining efficient protein N-glycosylation PMID: 20978011
    6. Reduced antibody response to BSA was observed in transgenic mice, suggesting that specific antibody response to tumor antigens might be suppressed by hMan2c1 transgene. PMID: 19572206
    7. plays an important role in preventing oncosis-like death in BJAB cells PMID: 12643454
    8. Results suggest that inhibition of alpha-mannosidase Man2c1 gene expression enhances adhesion of Jurkat T cells. PMID: 16721356
    9. Inhibition of MAN2C1 gene expression suppresses growth of esophageal carcinoma cells through mitotic arrest and apoptosis. PMID: 19018777

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Glycosyl hydrolase 38 family
  • 數據庫鏈接：

    HGNC: 6827

    OMIM: 154580

    KEGG: hsa:4123

    STRING: 9606.ENSP00000267978

    UniGene: Hs.26232



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