在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAL Antibody

  • 中文名稱:
    MAL兔多克隆抗體
  • 貨號(hào):
    CSB-PA913398
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA913398(MAL Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA913398(MAL Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    MAL
  • 別名:
    MAL; Myelin and lymphocyte protein; T-lymphocyte maturation-associated protein
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human MAL
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.
  • 基因功能參考文獻(xiàn):
    1. In high-grade serous ovarian carcinoma patients, MAL was overexpressed in platinum-resistant compared to platinum-sensitive patients and resulted as an independent prognostic marker of survival. PMID: 28545541
    2. MAL and TMEM220 were specifically methylated and were down-regulated in human gastric cancer. PMID: 27329150
    3. This study revealed that Merkel cell polyomavirus -negative Merkel cell carcinomas significantly expressed higher CADM1 and lower MAL than Merkel cell polyomavirus -positive Merkel cell carcinomas PMID: 26772392
    4. CADM1/MAL methylation increases with severity of cervical intraepithelial neoplasia PMID: 26219541
    5. Hypermethylation of the selected markers (MAL, PRIMA1, PTGDR and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer. PMID: 26482433
    6. Data suggest that expression of MAL in cells confers both ETX (Clostridium perfringens epsilon-toxin) binding and susceptibility to ETX-mediated cell death; cells expressing rat MAL are 100 times more sensitive to ETX than cells expressing human MAL. PMID: 25993478
    7. The use of CADM1, MAL, and MIR124-2 as biomarkers for full molecular screening in HIV infected women who are also positive for human papillomavirus. PMID: 26473640
    8. MAL is a critical element of the machinery for exosome secretion and may constitute a target for modulating exosome secretion by human T cells. PMID: 26109641
    9. MAL hypermethylation is associated with esophageal carcinoma progression. PMID: 24088706
    10. Cytology and bi-marker CADM1/MAL-methylation analysis perform complementary for CIN2+/CIN3+ detection when used as triage tool on cervical scrapes of HPV positive women. PMID: 25667975
    11. DNA methylation analysis of CADM1, MAL and miR124-2 in cervical scrapes consistently detects cervical cancer PMID: 25281766
    12. The MAL gene repression related with lymph node metastasis and poor prognosis in gastric cancer, suggesting that the MAL may be a new candidate node metastasis-suppressor gene for gastric cancer. PMID: 24511665
    13. CADM1 and MAL methylation levels increased proportional to severity of the underlying lesion PMID: 23456988
    14. hypomethylation of LINE-1 and hypermethylation of SLIT2, MAL and IGFBP7 were frequently detected in NSCLCs and associated with various clinical features. PMID: 23381221
    15. MAL protein plays an important role during oral carcinogenesis, MAL gene expression was significantly decreased in oral squamous cell carcinoma compared with normal epithelium. PMID: 23224601
    16. Data indicate that DNA methylation status of multiple genes CADM1, MAL and hsa-miR-124-2 was analyzed in human papillomavirus (hrHPV)-positive cervical scrape. PMID: 23176198
    17. the methylation marker panel CADM1-M18 and MAL-M1 may serve as an alternative molecular triage tool for hrHPV-positive women. PMID: 21190187
    18. Data show that a combination of CADM1 and MAL methylation could represent a promising candidate triage tool for hrHPV-positive women. PMID: 21389098
    19. MAL is normally expressed in laryngeal epithelial cells and its expression changes at early stages of carcinoma development. PMID: 19670627
    20. This study supports roles for tyrosines 86 and 106 in signaling pathways involving MAL. PMID: 20822478
    21. Data suggest that the epigenetic inactivation of MAL, as a candidate tumor suppressor gene, can contribute to human epithelial cell carcinoma and may be served as a biomarker in HNSCC. PMID: 21092172
    22. The caspase-1 cleavage site in Mal is part of a TIR-domain interaction site. PMID: 20048342
    23. Data show that MAL transcript levels were higher in the resistant ovarian cell lines. PMID: 19642140
    24. The mal gene which is switched-off in all esophageal squamous cell carcinoma samples can be considered as a tumor suppressor gene PMID: 15188492
    25. Caveolin-1 and MAL are located on prostasomes secreted by prostate cancer cells PMID: 15466889
    26. Quantitative analysis carried out using pixel intensity variance demonstrated that the MAL protein is capable of modifying the plasma membrane, thereby increasing its resistance to detergent-induced pore formation. PMID: 16785208
    27. Loss of MAL expression is aasociated with precancerous lesions of the esophagus PMID: 17151798
    28. Promoter hypermethylation of MAL, shown to be present in colorectal adenomas and carcinomas and only rarely in normal mucosa. PMID: 17408629
    29. promoter hypermethylation of MAL was present in the vast majority of benign and malignant colorectal tumors, and only rarely in normal mucosa PMID: 18346269
    30. MAL has a putative tumour-suppressor gene function in gastric cancer, and detection of promoter hypermethylation may be useful as a prognostic marker. PMID: 19002170
    31. Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. PMID: 19208741
    32. suggesting the MAL gene as a new metastasis-suppressor candidate for head and neck cancer PMID: 19445022

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    MAL family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6817

    OMIM: 188860

    KEGG: hsa:4118

    STRING: 9606.ENSP00000310880

    UniGene: Hs.80395



主站蜘蛛池模板: 久久精品免费国产大片| 无码av免费精品一区二区三区 | av天堂午夜精品一区| 一个人看的www免费视频在线观看| 欧洲熟妇牲交| 少妇精油按摩av无码中字| 国产杨幂丝袜av在线播放| 日本一卡2卡3卡4卡免费乱码网站| 亚洲人成色77777在线观看大战p| 性少妇中国内射xxxx狠干| 国产成人无码a区在线观看导航| 99久久国语露脸精品国产| 日韩精品一区二区三区影院| 欧美性群另类交| 尤物精品国产第一福利网站| 久久国产精品无码一区二区三区| 久久精品夜色噜噜亚洲a∨| 午夜成人爽爽爽视频在线观看| 国产孩cao大人xxxx| 国产精品久久久久影院亚瑟| 波多野结衣不打码视频| 无套内射视频囯产| 青青草无码伊人久久| 97超碰中文字幕久久精品| 噜噜久久噜噜久久鬼88| 巨爆乳中文字幕爆乳区| 久久久久人妻精品一区三寸| 国精品人妻无码一区免费视频电影| 国产激情高中生呻吟视频| 麻豆精品久久久久久久99蜜桃| 国精品无码一区二区三区在线蜜臀| 久久久久久妓女精品影院| 精品美女国产互换人妻| 天天躁日日躁狠狠躁免费麻豆| 国产精品青青在线观看爽香蕉| 国产亚洲欧美日韩精品一区二区| av中文无码韩国亚洲色偷偷 | 极品少妇hdxx麻豆hdxx| 久久久青草青草免费看| 99热成人精品国产免费| 欧美丰满熟妇xxxx性|