在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAGOH Antibody

  • 中文名稱:
    MAGOH兔多克隆抗體
  • 貨號:
    CSB-PA013364ESR2HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: MAGOH antibody at 4.36μg/ml
      Lane 1: Mouse kidney tissue
      Lane 2: A431 whole cell lysate
      Lane 3: Jurkat whole cell lysate
      Lane 4: Raji whole cell lysate
      Lane 5: K562 whole cell lysate
      Lane 6: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 18, 13 kDa
      Observed band size: 18 kDa
    • Immunoprecipitating MAGOH in Hela whole cell lysate
      Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA013364ESR2HU in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
      Lane 2: CSB-PA013364ESR2HU (4μg) + Hela whole cell lysate (500μg)
      Lane 3: Hela whole cell lysate (20μg)
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MAGOH Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MAGOH
  • 別名:
    Mago nashi homolog proliferation associated (Drosophila) antibody; Mago nashi protein homolog antibody; magoh antibody; MAGOHA antibody; MGN_HUMAN antibody; Protein mago nashi homolog antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Protein mago nashi homolog protein (1-146AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IP
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IP 1:200-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.
  • 基因功能參考文獻:
    1. Results provide evidence that MAGOH binding to the C-terminal region of Y14 disrupts Y14 nucleolar localization. PMID: 29330450
    2. findings show 2 genes MAGOH and MAGOHB are expressed in mammals; in macrophages, expression of MAGOHB but not MAGOH mRNA increases after LPS stimulation; both MAGOH proteins interact with other exon junction complex (EJC) components, incorporate into mRNA-bound EJCs and activate nonsense-mediated decay PMID: 23917022
    3. The stable association of multiprotein exon junction complex core with RNA is maintained by inhibition of eIF4AIII ATPase activity by MAGOH-Y14. PMID: 16170325
    4. crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase eukaryotic initiation factor 4AIII bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic PMID: 16931718
    5. These results indicate that MAGOH regulates the transcriptional activation of STAT3 by interfering complex formation between STAT3 and Y14. PMID: 19254694

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Nucleus speckle. Cytoplasm.
  • 蛋白家族:
    Mago nashi family
  • 組織特異性:
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6815

    OMIM: 602603

    KEGG: hsa:4116

    STRING: 9606.ENSP00000360525

    UniGene: Hs.421576



主站蜘蛛池模板: 女人大荫蒂毛茸茸视频| 四虎成人精品永久网站| 高清视频在线观看一区二区三区| 色欲香天天天综合网站| 日本一卡二卡不卡视频查询| 宅男66lu国产在线观看| 蜜臀av在线无码国产| 久久99精品久久久久久久不卡 | 中文在线а天堂中文在线新版| 国产色播av在线观看| 国产亚洲另类无码专区| 亚洲精品国产成人| 高中生自慰www网站| 无尺码精品产品视频| 免费高清av一区二区三区| 99热成人精品国产免费 | 午夜视频无码国产在线观看| 日99久9在线 | 免费| 欧美自拍另类欧美综合图片区| 在线永久免费观看黄网站| 亚洲色大成网站www永久一区| 亚洲国产成人精品无码区二本| 国内揄拍国内精品少妇| 日韩一区二区三区无码影院| 大学生被内谢粉嫩无套| 日本少妇寂寞少妇aaa| 国产精品亚洲综合色区韩国| 国产成人亚洲综合色婷婷| 忘忧草日本在线播放www| 麻豆成人久久精品综合网址| 免费裸体美女网站| 国产免费无码一区二区| 动漫成人无码精品一区二区三区 | 亚洲爆乳成av人在线视水卜| 永久免费无码网站在线观看| 3d动漫精品一区二区三区| 巨熟乳波霸若妻在线播放| 国产精品免费久久久久影院仙踪林 | 人妻无码中字在线a| 国产精品原创巨作av| 在线中文新版最新版在线 |