在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAGI2 Antibody

  • 中文名稱:
    MAGI2兔多克隆抗體
  • 貨號:
    CSB-PA213488
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HT-29 cells, using MAGI2 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MAGI2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human MAGI2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.
  • 基因功能參考文獻:
    1. MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling. PMID: 29679339
    2. MAGI-2 immunoreactivity is elevated in prostate cancer and high-grade prostatic intraepithelial neoplasia compared with normal tissue, suggesting that MAGI-2 may contribute to prostate carcinogenesis. PMID: 26980016
    3. Immunohistochemistry in kidney sections from these patients revealed that mutations resulted in lack of or diminished podocyte MAGI2 expression. Our data support the finding that mutations in the MAGI2 gene are causal for congenital steroid-resistant nephrotic syndrome PMID: 27932480
    4. MAGI-2 could represent a useful adjunct for diagnosis of prostatic adenocarcinoma PMID: 27543977
    5. The expression of MAGI2 mRNA was significantly down-regulated in PC3, LNCaP and DU-145 PCa cell lines. PMID: 24985972
    6. MAGI2, SERPINE2, and NT5C3B expression levels are associated with airway wall thickening and additionally with bronchial inflammation, emphysema, and lung function, respectively, all features of chronic obstructive pulmonary disease. PMID: 25517131
    7. Data show that the miR-134/487b/655 cluster regulates TGF-beta1-induced epithelial-mesenchymal transition and affected the resistance to gefitinib by directly targeting membrane-associated guanylate kinase, WW, and PDZ domain-containing protein 2 (MAGI2). PMID: 24258346
    8. In Usher syndrome 1G, mutations in SANS eliminate Magi2 binding and thereby deregulate endocytosis, lead to defective ciliary transport modules and ultimately disrupt photoreceptor cell function inducing retinal degeneration. PMID: 24608321
    9. MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability. PMID: 23754155
    10. Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients. PMID: 22649501
    11. Results presented herein provide further evidence for a role of MAGI2 in bipolar affective disorder and schizophrenia etiology. PMID: 22381734
    12. Interstitial deletions that include the MAGI2 gene on chromosome 7q11.23-q.21.11 are associated with IS cases. PMID: 18565486
    13. there was no association of MAGI2 and PARD3 with IBD. PMID: 21515326
    14. analysis of 7q11.21-q11.23 and infantile spasms without deletion of MAGI2 [case report] PMID: 20101691
    15. Data show that AIP1 is a novel GTPase-activating protein for Arf6, a small GTPase regulating cellular PIP(2) production and formation of the TLR4-TIRAP-MyD88 complex. PMID: 19948740
    16. PTEN plays a critical role in MAGI-2-induced inhibition of cell migration and proliferation in human hepatocarcinoma cells PMID: 17880912
    17. MAGI2 genetic variation is associated with inflammatory bowel disease. PMID: 18720471

    顯示更多

    收起更多

  • 相關疾病:
    Nephrotic syndrome 15 (NPHS15)
  • 亞細胞定位:
    Cytoplasm. Late endosome. Cell junction, synapse, synaptosome. Cell membrane; Peripheral membrane protein.
  • 蛋白家族:
    MAGUK family
  • 組織特異性:
    Specifically expressed in brain.
  • 數據庫鏈接:

    HGNC: 18957

    OMIM: 606382

    KEGG: hsa:9863

    STRING: 9606.ENSP00000346151

    UniGene: Hs.603842



主站蜘蛛池模板: 亚洲国产精品久久网午夜| 全部免费毛片在线播放| 精品无码一区二区三区电影 | 羞羞色男人的天堂 | 国精品人妻无码一区二区三区性色 | 综合亚洲综合图区网友自拍| 久久视频在线视频精品| 人妻系列无码专区久久五月天| 国产午夜片无码区在线播放| 中国少妇xxxx做受| 亚洲中文字幕av每天更新| 欧美亚洲国产精品久久蜜芽| 无码人妻精品一区二区三区久久久| 精品无码国产av一区二区三区| 中文字幕在线影视| 精品国产v无码大片在线观看| 日本乱子人伦在线视频| 久久中文字幕无码专区 | 国产国拍亚洲精品av| 思思99re6国产在线播放| 精品久久久久久无码中文字幕一区 | 无码人妻av一区二区三区蜜臀| 亚洲精品无码精品mv在线观看| 亚洲欧美日韩国产成人| 亚洲精品一区二区三区四区五区| 欧美人和黑人牲交网站上线| 国产精品无码成人午夜电影| 精品国产午夜福利精品推荐| 久久亚洲精品成人无码网站夜色| 玩弄人妻少妇500系列网址| 亚洲国产精品久久久久秋霞影院| 青青草视频在线观看| 自拍偷在线精品自拍偷免费| 乌克兰性欧美精品高清| 极品人妻被黑人中出种子| 亚洲自偷自偷图片| 成人爽a毛片免费啪啪| 熟女视频一区二区在线观看 | 青草久久人人97超碰| 天天射寡妇射| 国产一区二区内射最近更新|