在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAGI1 Antibody

  • 中文名稱:
    MAGI1兔多克隆抗體
  • 貨號:
    CSB-PA013360GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    AIP 3 antibody; AIP-3 antibody; AIP3 antibody; Atrophin 1 interacting protein 3 antibody; Atrophin-1-interacting protein 3 antibody; BAI1 associated protein 1 antibody; BAI1-associated protein 1 antibody; BAIAP 1 antibody; BAIAP1 antibody; BAP 1 antibody; BAP-1 antibody; BAP1 antibody; Gukmi1 antibody; MAGI 1 antibody; MAGI-1 antibody; MAGI1 antibody; MAGI1_HUMAN antibody; MAGI1c antibody; Membrane associated guanylate kinase inverted 1 antibody; membrane associated guanylate kinase WW and PDZ domain containing 1 antibody; Membrane-associated guanylate kinase antibody; Membrane-associated guanylate kinase inverted 1 antibody; TNRC 19 antibody; TNRC19 antibody; Trinucleotide repeat containing gene 19 antibody; Trinucleotide repeat containing gene 19 protein antibody; Trinucleotide repeat-containing gene 19 protein antibody; WW and PDZ domain-containing protein 1 antibody; WW domain containing protein 3 antibody; WW domain-containing protein 3 antibody; WWP 3 antibody; WWP3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human MAGI1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface.
  • 基因功能參考文獻:
    1. Decreased MAGI1 expression in the colonic mucosa might contribute to the pathogenesis of microscopic colitis. PMID: 29204743
    2. it negatively controls the cell growth of various types of cells and positively controls cell-cell interaction and the decreased expression of MAGI-1 in human T cells contributes to the development of several types of T-cell leukemia, partly through the stimulation of the Akt and MEK pathways. PMID: 29043551
    3. Study presented a combined molecular dynamics/infrared spectroscopy approach to the study of ligand binding (11-residue peptide derived from the C terminus of HPV16 E6) by the PDZ1 domain of MAGI1, focusing in particular on the far-infrared region of the spectrum. PMID: 28636914
    4. Here we present the result of a 4-stage genome-wide association study composed of 5,953 adolescent idiopathic scoliosis patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 , rs7633294 at 3p14.1 near MAGI1 and rs9810566 at 3q26.2 near TNIK PMID: 28334814
    5. A deletion at ADAMTS9-MAGI1 locus is associated with psoriatic arthritis risk. PMID: 25990289
    6. MAGI1 rs35855737 is a novel locus for neuroticism. [Meta-Analysis] PMID: 25993607
    7. Variants in MAGI1 were associated with a Crohn's disease phenotype involving a complicated stricturing disease course. PMID: 25557950
    8. The data suggests that inactivation of MAGI-1 by the NS1 protein from avian influenza A virus elicits an interferon-beta induction signal. PMID: 22911767
    9. The PDZ1 and PDZ3 domains of MAGI-1 regulate the eight-exon isoform of the CXADR-like membrane protein. PMID: 22718816
    10. MAGI1 may inhibit the cancer cell migration and invasion of hepatocellular carcinoma via regulating PTEN. PMID: 21685691
    11. Results presented herein provide further evidence for a role of MAGI1 in bipolar affective disorder and schizophrenia etiology. PMID: 22381734
    12. MAGI1 expression is decreased in hepatocellular carcinoma, which correlates with poor prognosis, suggesting MAGI1 as a novel prognostic marker PMID: 21942217
    13. HPV16 E6 association with PDZ domain-containing proteins, MAGI1, Dlg1 or Scrib, stabilized the levels of E6. PMID: 21489588
    14. Mutations designed in the C-terminal flanking region of the human MAGI-1 PDZ domain resulted in a significant decrease in binding affinity for human papillomavirus E6 peptides. PMID: 21238461
    15. These results demonstrate that oncogenic HPV E6 proteins disrupt cellular tight junctions through the degradation of MAGI-1. PMID: 21123374
    16. Data conclude that the up-regulation of sdk-1 in podocytes is an important pathogenic factor in glomerulosclerosis and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 function. PMID: 20562105
    17. interaction with synaptopodin and alpha-actinin-4 PMID: 12042308
    18. Dll1 is presented on the surface of AJs formed at the apical termini of processes through interaction with MAGI1 to activate Notch on neighboring cells in the developing central nervous system PMID: 15908431
    19. In vitro binding assays using the partial cDNA as a GST fusion protein confirm the binding to full-length MAGI-1 expressed in HEK293 cells. PMID: 16019084
    20. MAGI-1 is important for vascular endothelial-cadherin-dependent Rap1 activation upon cell-cell contact. PMID: 16339077
    21. MAGI-1 cleavage appears to be an important step in the disassembly of cell-cell contacts during apoptosis. PMID: 17191119
    22. Structural basis for controlling the dimerization and stability of the WW domains of MAGI1 is reported. PMID: 18562638

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, tight junction. Cell membrane; Peripheral membrane protein. Note=Localizes to epithelial cells tight junctions.
  • 組織特異性:
    Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expres
  • 數據庫鏈接:

    HGNC: 946

    OMIM: 602625

    KEGG: hsa:9223

    STRING: 9606.ENSP00000385450

    UniGene: Hs.476636



主站蜘蛛池模板: 成人片无码免费播放| 久久久亚洲精华液精华液精华液| 亚洲精品久久午夜无码一区二区 | 亚欧色一区w666天堂| 亚洲乱亚洲乱少妇无码99p| 久久婷婷色香五月综合缴缴情| 人妻久久久精品99系列2021| 中文字幕 乱码 中文乱码视频| 狠狠躁夜夜躁人人躁婷婷视频| 三级4级全黄60分钟| 少妇无码一区二区二三区| 久久久综合九色合综国产精品| 国产精品爽爽久久久久久无码 | 久久亚洲国产成人精品性色| 午夜男女爽爽影院免费视频下载| aaa少妇高潮大片免费看| 天天爽夜夜爽人人爽从早干到睌| 人人妻人人爽人人添夜夜欢视频| 精品无码国产自产拍在线观看| 强睡邻居人妻中文字幕| 国产伦子系列沙发午睡| 久久精品99无色码中文字幕| 成人午夜精品无码一区二区三区| 一二三四在线视频社区3| 99蜜桃臀久久久欧美精品网站 | 久久久精品国产sm最大网站| 亚洲精品无码久久千人斩| 狠狠亚洲色一日本高清色| 久久久久99精品成人片| 丰满人妻一区二区三区视频53| 欧美一性一乱一交一视频| 中国少妇内射xxxhd| 欧美日韩亚洲中文字幕一区二区三区| 男女做爰猛烈叫床视频免费| 国产精品一区二区久久精品| 蜜乳av久久久久久久久久久| 亚洲国产中文在线视频| 国产av一区二区三区传媒| 色综合天天视频在线观看| 国产一区丝袜高跟鞋| a在线视频v视频|