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  4. MAGEA11 Antibody

MAGEA11 Antibody

  • 中文名稱：
    MAGEA11兔多克隆抗體
  • 貨號：
    CSB-PA594626
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA594626(MAGEA11 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    MAGEA11
  • 別名：
    MAGEA11 antibody; MAGE11Melanoma-associated antigen 11 antibody; Cancer/testis antigen 1.11 antibody; CT1.11 antibody; MAGE-11 antigen antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human MAGEA11
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.
  • 基因功能參考文獻：
    1. SUV39H2 functioned cooperatively with MAGE-A11 to increase androgen-dependent AR transcriptional activity. PMID: 28042025
    2. direct interactions of MAGE-A11 with Skp2 and cyclin A regulate the substrate-specificity of Skp2-mediated protein degradation. PMID: 27720894
    3. MAGE-A11 and androgen receptor cooperate in the up-regulation of FSTL1 to promote the growth of prostate cancer. PMID: 27976415
    4. MAGE-A11 is an independent poor prognostic marker for esophageal squamous cell carcinoma (ESCC) patients. MAGE-A11 regulates various cell functions and directly increases the invasion and proliferation of ESCC cells. PMID: 27362547
    5. degradation of MAGE-A11 promoted by the human p14-ARF tumor suppressor contributes to low levels of MAGE-A11 in nontransformed cells PMID: 26330556
    6. MAGE-A11, similarly to HER-2 and ER-beta, may be an important diagnostic or prognostic indicator in breast cancer and potentially promotes tumor proliferation. PMID: 23064813
    7. MAGEA11 regulation is highly instructive for understanding mechanisms regulating CG antigen genes in human cancer. PMID: 23839233
    8. MAGE-A11 is a proto-oncogene whose increased expression in prostate cancer reverses retinoblastoma-related protein p107 from a transcriptional repressor to a transcriptional activator of the androgen receptor and E2F1. PMID: 23853093
    9. MAGE-A11 increases AR transcriptional activity by linking androgen receptor dimers. PMID: 23172223
    10. the functional defect associated with an AR exon 1 missense mutation. PMID: 22334658
    11. Gain in transcriptional activity by primate-specific coevolution of melanoma antigen-A11 and its interaction site in androgen receptor. PMID: 21730049
    12. MAGE-11 links NH(2)-terminal domains of AR and p300 to promote transcriptional synergy through a cadre of FXXLF-related interacting motifs PMID: 20448036
    13. Results suggest that MAGE-11 functions as a bridging factor to recruit androgen receptor coactivators through a novel FXX(L/I)F motif-F-box interaction paradigm. PMID: 19828458
    14. MAGE-11 is a unique AR coregulator that increases AR activity by modulating the AR interdomain interaction. PMID: 15684378
    15. The results suggest that MAGE-11 functions as a coregulator that increases AR transcriptional activity during the establishment of uterine receptivity in the human female. PMID: 18048459
    16. The time-dependent EGF-induced increase in AR transcriptional activity by MAGE-11 is mediated through AR activation functions 1 and 2 in association with the increased turnover of AR and MAGE-11. PMID: 18212060
    17. Knockdown of MAGE-11 by small interfering RNA results in decreased hypoxic induction of HIF-1alpha and its target genes. Inhibition of PHD by MAGE-11, and following activation of HIFs, is a novel tumor-associated HIF regulatory mechanism. PMID: 19147576
    18. Increased expression of the AR coregulator MAGE-11 through promoter DNA hypomethylation and cyclic AMP is associated with prostate cancer PMID: 19372581

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  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 組織特異性：
    Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal tissue.
  • 數據庫鏈接：

    HGNC: 6798

    OMIM: 300344

    KEGG: hsa:4110

    STRING: 9606.ENSP00000347358

    UniGene: Hs.670252



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